Revealing facts about vaccines

9/23/2021 4:26:52 PM

Revealing facts about the COVID19 vaccines

Why not decide to get vaccinated based on the available evidence?


With the emergence of SARS-CoV-2, Human society was hit from an unexpected point. Health organizations did their best to control and treat new diseases, but they encountered numerous deadlocks to contain this virus. It soon became clear that global vaccination is the only certain way to stop this disaster, like many other pandemics in the past.

As the Infectious Diseases Team, we strongly support vaccination. We tend to present a more evidence-based view.

Various types of covid-19 vaccines are currently available and  the mRNA and vector-based vaccines are among the most successful and challenging vaccines.

The Centers for Disease Control and Prevention (CDC) states that "Researchers have been studying and working with mRNA vaccines for decades. mRNA vaccines have been studied before for flu, Zika, rabies, and cytomegalovirus (CMV) The creation of viral vectors began in 1970. Some vaccines recently used for Ebola outbreaks with viral vector technology." Therefore, unlike rumors about the safety of these vaccines, the mechanism has been confirmed through the years. CDC explains: "In both of these mechanisms, the cell displays the protein piece on its surface. Our immune systems recognize that the protein doesn't belong there and begin building an immune response and making antibodies. At the end of the process, our bodies have learned how to protect against future infection." (1)

On 3 Apr 2020 mortality rate was 20.58%, and this rate on 19 Sept 2021 was 2.23%, and the recovery rates on the exact dates were 79.42% and 97.77%, respectively. These numbers clearly revealed that after vaccination, the mortality rate decreased, and the recovery rate increased. (Figure 1) (2)

In addition to a decrease in mortality rate Vaccination can reduce the risk of further mutations. The new research was published in "The conversation," which assumed that the coronavirus remained essentially unchanged for months until the pandemic got out of control and nearly a million new infections occurred globally every day. Therefore, the emergence of new, more contagious variants, like delta, is being driven by uncontrolled transmission. The genetic code had limited opportunities to mutate by the control of this virus. Therefore the best way to stop new variants is to prevent their spread, and the best answer is vaccination. (3)

Figure 1:


According to the Centers for Disease Control and Prevention (CDC), "The amount of natural immunity a person gets after an infection varies from person to person and early evidence suggests that natural immunity may not last very long. Developing immunity from the vaccine is less risky than developing immunity naturally because there's no way to predict the severity of your symptoms if you get COVID-19". (4) Based on new research on the safety of mRNA Covid-19 Vaccine in a Nationwide Setting, the types of vaccine complications and their incidence in vaccinated people and those getting infected without vaccination were carefully listed. After analyzing their data, they found out that the risk of potential myocarditis and many other adverse severe events substantially increased after SARS-CoV-2 infection and suggested that getting vaccinated is safer. (5)

As mentioned in the introduction, mRNA and vector-based vaccines have been studied for decades, and no evidence is available suggesting that these vaccines can cause cancer because of integration with the human genome. Our statement is supported by an article published at "The Conversation" by José María Jiménez Guardeño, a researcher at the Infectious Diseases Department at King's College London, and Ana María Ortega-Prieto, a postdoctoral researcher, also associated with King's College London. This article disproves entirely that mRNA can alter our DNA and result in mutation of the genome. (6)

As for the vector-based vaccines, the only article suggesting that these novel vaccine mechanisms can integrate with human DNA and lead to mutation or cell death gives this hypothesis only for some vector-based vaccines that should blend with the human DNA to cause immunization, but the vector-based covid-19 vaccine does not integrate with human DNAs. (7)

Despite many concerns about vaccines causing autoimmunity, the "American college of rheumatology" recommends complete vaccination for patients with autoimmune disorders. They released guidance on 15 Jun 2021 and stated that "based on evidence published to date, the expected benefits of the COVID-19 vaccine outweigh the potential for vaccine harm in most rheumatic and musculoskeletal diseases (RMD) patients." (8)

If you are reading this article, you have undoubtedly heard about cytokine storms (C.S.). C.S. is a fast-developing, life-threatening clinical condition in which the overproduction of inflammatory cytokines and excessive activation of immune cells lead to complicated medical syndromes. multiple studies have reported that highly elevated levels of pro-inflammatory cytokines are produced during the crosstalk between epithelial cells and immune cells in COVID-19, which has linked the cytokine storm (C.S.) with severe complications and poor outcomes of this infection. (9) therefore, the vaccines do not lead to cytokine storm, and an article is published discussing their concern about whether the vaccines could prevent C.S. or not. (10)

After the outbreak of delta variant, another concern was:" vaccines are not working for new variants"; however, recently released research reveals that vaccines are as effective as they were. These results suggest rapid early waning of Efficacy against hospitalized COVID-19 after the second dose tapers off within a few months. This weakens the rationale for policies based on delivering booster doses to the entire population. (11)

Now let statistics speak out!

We want to make something clear about determining the Efficacy of vaccines. The RRR (relative risk reduction) is used to estimate vaccine efficacy, and Absolute risk reduction (ARR) is directly related to the number of people infected in the control group and is not valid for determining vaccine efficacy. To prove this statement, we would like to refer to a study result: "a study enrolled 20,000 patients into the control group and 20,000 in the vaccine group. In that study, 200 people in the control group got sick, and 0 people in the vaccine group got sick. Even though the vaccine efficacy would be a whopping 100%, the ARR would show that vaccines reduce the absolute risk by just 1% (200/20,000= 1%). For the ARR to increase to 20% in our example study with a vaccine with 100% efficacy, 4,000 of the 20,000 people in the control group would have to get sick (4,000/20,000= 20%)." (12)

Based on three huge research released by CDC on 10 Sept 2021, people who were not fully vaccinated in spring and summer had more than 10 times higher COVID-19 mortality risk. (Figure 2) (13)

Figure 2: Observed versus expected percentage of fully vaccinated persons among COVID-19 cases, hospitalizations, and deaths based on population vaccination coverage

Figure 3: daily new deaths in the U.K.

We know that vaccines have pros and cons; however, some of these disadvantages are unproven hypotheses based on valid evidence. We have a brilliant history of vaccines that result at the end of pandemic disasters. Therefore, our opportunity for termination of this catastrophic state is vaccination.
So don't hesitate; get vaccinated!

By: Kimia Taslimi, Mosleh Sedighi, Samin Khalifeh Soltani, Ali Parouhan and supervised by Dr. FereshtehGhiasvand


  1. Understanding mRNA COVID-19 Vaccines 2021 [updated 4 Mar 2021. Available from:
  2. [Available from:
  3. Vaughn Cooper LH. Massive numbers of new COVID–19 infections, not vaccines, are the primary driver of new coronavirus variants 2021 [Available from:
  4. Cavanaugh AM, Spicer KB, Thoroughman D, Glick C, Winter K. Reduced Risk of Reinfection with SARS-CoV-2 After COVID-19 Vaccination — Kentucky, May–June 2021. MMWR Morb Mortal Wkly Rep 2021;70:1081-1083.
  5. Barda, N., et al. (2021). "Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting." New England Journal of Medicine 385(12): 1078-1090.
  6. Jose Manuel Jimenez Guardeño AMO-P. No, las vacunas de ARN frente a la covid-19 no modificarán nuestro genoma 2020 [Available from:
  7. Ura, Takehiro et al. "Developments in Viral Vector-Based Vaccines." Vaccines vol. 2,3 624-41. 29 Jul. 2014
  8. Yang L, Xie X, Tu Z, Fu J, Xu D, Zhou Y. The signal pathways and treatment of cytokine storm in COVID-19. Signal Transduction and Targeted Therapy. 2021;6(1):255.
  9. Jee Young Chung MNT, Young Jik Kwon. COVID-19 vaccines: The status and perspectives in delivery points of view. elsevier. 2021;170:1-25.
  10. Curtis JR JS, Anthony DD, Arasaratnam RJ, Baden LR, Bass AR, et al. American College of Rheumatology Guidance for COVID-19 Vaccination in Patients with Rheumatic and Musculoskeletal Diseases – Version 3 2021 [updated 4 Aug, 2021. Available from:
  11. McKeigue PM, McAllister DA, Hutchinson SJ, Robertson C, Stockton D, Colhoun HM, et al. Efficacy of vaccination against severe COVID-19 in relation to Delta variant and time since second dose: the REACT-SCOT case-control study. medRxiv. 2021:2021.09.12.21263448.
  12. Olliaro, Piero et al. "COVID-19 vaccine efficacy and effectiveness-the elephant (not) in the room." The Lancet. Microbe vol. 2,7 (2021): e279-e280.
  13. Scobie HM, Johnson AG, Suthar AB, et al. Monitoring Incidence of COVID-19 Cases, Hospitalizations, and Deaths, by Vaccination Status — 13 U.S. Jurisdictions, 4 Apr–17 Jul, 2021. MMWR Morb Mortal Wkly Rep 2021;70:1284–1290.

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