Curriculum Vitae

Saeid Ghavami , B.Sc, M.Sc, Ph.D

Contact Information:

Dept. of Human Anatomy and Cell Science, University of Manitoba

Winnipeg, MB, R3E 3P4

Tel: +1-(204) 612-8956      E-mail: saeid.ghavami@umanitoba.ca, saeid.ghavami@gmail.com

                                    

Education

Ph.D in Clinical Biochemistry                                                                                                        1998-2004

Tarbiat Modarres University, School of Medicine, Tehran, Iran.

Thesis title: Apoptotic effect of Calprotectin (S100A8/A9) on colon cancer cells (HT29/219 and SW742).

M.Sc in Clinical Biochemistry                                                                                                        1993-1996

Tarbiat Modarres University, School of Medicine, Tehran, Iran.

Thesis title: Role of Alpha-1 antitrypsin in idiopathic neonatal liver disease.

B.Sc in chemistry, Shiraz University, School of Sciences, Iran.                                            1984-1989

Nationality

Canadian

Iranian

Current Position: University of Manitoba, Canada

Tenure Track Assistant Professor: Department of Human Anatomy and Cell Science       Nov 2013-Present

Current Position: Shiraz University of Medical Sciences

Honorary Professor: Shiraz University of Medical Sciences, Health Research Policy Centre,                                                                           June 2014-Present

Founder and Co-director of Autophagy Research Center: Iranian Elite Center, Shiraz University of Medical Sciences, Health Research Policy Centre,    January 2016-Present

Post Doctoral Training and Research Experience

1) Visiting Scientist/Assistant Professor in Airway Biology                                           Sept 2013-Oct. 2013

Project Title:  Role of Autophagy and ER-stress in Airway Biology

Mentor: Dr. Amir Zeki, Division of Respiratory, Critical Care & Sleep, University of California Davis

Davis, California, USA

2) Senior Post Doctoral Fellow in Heart Disease                                                                Dec 2012-Aug. 2013

Project Title:  Role of Autophagy and ER-stress in Cellular Phenotype Conversion

Mentor: Dr. Ian Dixon, Departments of Physiology, University of Manitoba

Winnipeg, Manitoba, Canada

3) Visiting Scientist in ER-Stress and Autophagy Cross-talk                                           Nov 2012-Dec. 2012

Mentor: Dr. Afshin Samali, PhD. Departments of Biochemistry, National University of Ireland, Galway, Ireland

4) Parker B Francis Fellow in Respiratory Disease,                                                           Jan 2010-Sep. 2012

Project Title:  Role of S100A8/A9 in Airway Remodeling during Asthma

Mentor: Dr. Andrew J Halayko, PhD. Departments of Physiology & Internal Medicine, and Section of Respiratory

Disease, University of Manitoba, Winnipeg, Manitoba, Canada

5) Post Doctoral Fellow                                                                                                 July 2007-Jan 2010

Project Title: Application of Cell Death in Airway Remodeling and Asthma Therapy

Mentor: Dr. Andrew J Halayko, PhD. Departments of Physiology & Internal Medicine, and Section of Respiratory

Disease, University of Manitoba, Winnipeg, Manitoba, Canada

6) Post Doctoral Fellow                                                                                                  Nov 2004-July 2007

Project Title: Application of Cell Death in New Cancer Therapy

Mentor: Dr. Marek Los, MD/PhD, Manitoba Institute of Cell Biology, CancerCare Manitoba, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada

Current Funding

1. National Institute for Medical Research Development (NIMAD) (55,000 C$): Tittle: Elucidating autophagy pathways as a new therapeutic target for leukemia drug development. Role: Co-applicant            March 2015-March 2018.

1. Health Science Foundation (70,000 C$): Tittle: Simvastatin and Glioblastoma Chemotherapy. Role: Co-applicant.                                                                                               September 2016-August 2018

1. MITACS Accelerate (45,000 C$): TMZ and Glioblastoma Chemotherapy. January 2017- January 2018

1. National Institute for Medical Research Development (NIMAD) (65,000 C$): Tittle: How Mevalonate Cascade inhibition modulates TMZ induced cell death in glioblastoma. Role: Principal Investigator,  October 2016-March 2019.

1. University Collaborative Research Program (URCP) (25,000 C$): Tittle: Therapeutic effect of Temozolomide in Rhabdomyosarcoma: how autophagy regulated Temozolomide induced Cell Death. Role: Principal Investigator.   March 2017-March 2019.

1. Children Hospital Research Institute of Manitoba (CHRIM) Operating Grant (40,000): Tittle: Investigating the role of Mcl-1 in Temozolomide-induced cell death in Rhabdomyosarcoma Cells. Role: Principal Investigator. June 2017-June 2018.

1. Research Manitoba New Investigator Operating Grant (225,000 C$):  Title: Autophagy and Metastasis in Non-Small Lung Cancer: How does Autophagy Modulate Epithelial Mesenchymal Transition., Role: Principle Investigator, , September 2017-August 2020.

1. National Institute for Medical Research Development (NIMAD) (100,000 C$): Tittle: Asthma and Allergic Asthma. Role: Principal Investigator, September 2017-August 2020.

Applied Funding (Pending and Under Review)

1. Cancer Research Society Operating Grant (February 2018) (120,000 C$): Title: Investigating the role of temozolomide-induced autophagy and cell death in 2D and 3D bioengineered culture platform for treatment of rhabdomyosarcoma, (Under Review), Principal Investigator, September 2017-August 2019.

1. NSERC Discovery Grant (November 2017) (275,000 C$): Tittle: Mitophagy and Lung Cellular Phenotype, (Under Review), Principal Investigator, September 2018-August 2023.

1. Thorlakson Operating Grant (March 2018) (30,000 C$): Tittle: Mitophagy and Regualtion of Lung Cancer Metastasis (Under Review), Principal Investigator, September 2018-August 2019.

Previous Operating Research Grants

1. Start up Fund (125,000 C$)                                                                                                 2014-2017

1. Research Manitoba Graduate Studentship (Mr. Javad Alizadeh)   (17,000 C$), Tittle: Autophagy and EMT in Non-small Cell Lung Cancer.                                                                    Sept 2016-Sept 2017

1. International Cooperation for Applied Research Development (ICARD) (15,000 C$): Tittle: Targeting Autophagy as a Strategy for Modulation of Leukemic Stem Cell Differentiation/Dediffernatiotion in Acute Myelocytic Leukemia. Role: Co-applicant.                                                             Sept 2015-Sept 2017

1. Manitoba Medical Foundation Service Operating Grant (April 2015) (21,500 C$), Tittle: Autophagy is a Target for Modulation of Epithelial Mesenchymal Transition in Lung Cancer, Role: Principle Investigator,                                                                                                                     2015-2016.
2. University of Manitoba Research Grant (June 2015), Title: Autophagy and Tumor Metastasis in Lung Cancer, Role: Principle Investigator, (Funded) (7,500 C$).                            June 2015-January 2016.

1. MITACS Globalink Program (June 2016), Title: Mevalonate Cascade and Glioblastoma Multifom, Role: Principal Investigator, (Funded, 10,000 C$)). Summer 2016.

1. MITACS Globalink Program (June 2015), Title: Improving Breast Cancer Therapy Strategies by Inhibiting the Cholesterol Biosynthesis Pathway, Role: Principal Investigator, (Funded, 10,000 C$)). Summer 2015.

1. Manitoba-Regional Partnership Program with CIHR (Co-Applicant with Dr. Andrew J Halayko), “The S100A8/A9-RAGE Axis in Airway Inflammation, Hyper-Responsiveness, and Remodeling”          (227,824 CAN$)   
2. Canadian Institute of Health Research (Dr. Andrew J Halayko, Dr. Saeid Ghavami, Dr. John Gordon), “The S100A8/A9-RAGE Axis in Airway Inflammation, Hyper-Responsiveness, and Remodeling” (150,000 CAN$/year)                October 2010-2015
3. Research Operating Grant “Degradation of alpha 1 antitrypsin by matrix metalloproteinase and its role in Vernalkeratocunjunctivitis” , Zahedan Medical University, Zahedan, Iran, Principle Investigator                                                           2002-2004

1. Research Operating Grant “Role of Alpha-1Antitrypsinn Phenotypes in Uveitis”, Zahedan Medical University, Zahedan, Iran, Principle Investigator                                                                         1995-1999

1. Research Grant “Alpha-1 Antitrypsin in Viral Hepatitis B and C”, Zahedan, Medical University, Zahedan, Iran, Principle Investigator                                            1993-2000

Fellowships

1. Parker B Francis Career Development Fellowship in Respiratory Disease, “Role of S100A8/A9 in Airway Remodeling in Asthma” (156,000 US$) (Ranked top ten in North America)                                                                                                                                             2010- 2013                                                                                                                
2. CIHR/CLA/GSK PDF in Respiratory Disease (90,000 CAN$) (Ranked Number 1 in basic research in Canada)                                                           2008-January 2010

1. CIHR PDF Award, National Training Program in Allergy and Asthma (12,000 CAN$)                                                                                                                       2007-2009

1. Manitoba Institute of Child Health PDF Award (70,000 CAN$)                        2007-2009

1. Manitoba Health Research Council PDF Award (38,750 CAN$)

            (Ranked Number 1 in Manitoba)                                             June 2006- June 2007

1. Manitoba Health Research Council PDF Award (36,250 CAN$, Declined)

      (Ranked Number 3 in Manitoba)                                                                         2007

1. CIHR PDF Award (30,000 CAN$, Declined)                                                          2006

1. Health Science Center, University of Manitoba PDF Award (15,000 CAN$, Declined)                                                                                                            2006

1. CancerCare Manitoba Foundation PDF Award (30,000 CAN$)     June 2005- June 2006

1. Postgraduate Scholarship, Iran Ministry of Health and Medical Education      1993- 1995

Honors and Travel Awards

1. I got CIHR/CCS/OICR early career New Investigator Award                                                                                           Nov. 2017
2. My PDF (Dr. Shojaei) got CIHR/CCS/OICR early career New Investigator Award                                                                                           Nov. 2017
3. I got the award of “Science and Innovation Center (SIC) Rising Star of Research” from American Thoracic Society RSF Assembly                                                                                            May 2017
4. Mr. Adel Rezaei Moghadam (my MSc. Student) got Experimental Biology Travel Award (1000 US$)                                                                                                 January 2017
5. Mr. Adel Rezaei Moghadam (my MSc. Student) got Bronze medal for presentation in Children Hospital Research Day (1000 US$)                                                                                                 October 2016
6. Mr. Javad Alizadeh (my MSc. Student) got first prize for Human Anatomy and Cell Science Poster Award Presentation (400 C$)                                                                                                
7. Mr. Javad Alizadeh (my MSc. Student) got Ralph Mann award for excellence of Research      Jan 2016  
8. Ranked as 5^th Biomedical Researcher in 18^th International Razi Medical Award                             2013
9. CTS McDonald Memorial  Travel Award (500 C$)                                                                                2013
10. Travel Award From American Thoracic Society (ATS) Meeting, (RCMB) (500 US$)                                                                                                                           2011
11. Manitoba Institute of Child Health travel Award for attending ATS (1,000 C$)          2011
12. Travel Award, Keystone Symposia “Extra-cellular Matrix Remodeling in Cardiovascular Disease”      (1,200 US$)                                                                     Jan 23-28 2011
13. Travel Award, Society of the Free Radical Biology and Medicine (1,000 US$)  Nov 2009
14. First Prize in Manitoba Research Day in Post Doctoral Category (1,500 C$)                                                                                                                                       June 2009

1. Manitoba Institute of Child Health travel Award for attending Third Cell Death Meeting and Training Meeting (APOTRAIN), Ulm, Germany (1,500 C$)                               2008

1. Third Prize in CancerCare Research Day Competition, Manitoba (250 C$)            March 30th 2007

Current Supervisory and Co-Supervisory Trainee

1. BSc. Project Student (Mr. Arya Emami) Supervisor.

                           Project: Statin/TMZ combination in treatment of Rhabdomyosarcoma         May 2017-August 2018

1. BSc. Project Student (Mr. Amir Vosoughi) Supervisor.

                          Project: Statin/TMZ combination in treatment of Glioblastoma        May 2017-August 2018.

1. Postdoctoral Research Fellow (Dr. Shahla Shojaei) Co-Supervisor with Dr. Thomas Klonisch .

                           Project: Statin/TMZ combination in treatment of Glioblastoma        Jan 2017-Jan 2018.

      5. Postdoctoral Research Fellow (Dr. Mozaher Ahmadi) Co-Supervisor with Dr. Madrakian .

                        Project: Biosynthesis and Characterization of Statin Nanoparticle to target glioblastoma cells       Aug   2017-Aug 2018.

      6. Postdoctoral Research Fellow (Dr. Hesamaldin Movassagh) Co-Supervisor with Dr. Ji Hyun Ko .

                          Project: Targeting Mitophagy in Non-small cell lung cancer mouse model to modulate metastasis      Nov 2017-Nov 2019.

1.      7.   BSc. Med. Student (Mr. Daniel Kroft), Co-Supervisor,

           Project: Statin/Metformin Combination new target for Medulloblastoma     June 2017-September 2019

Current Academic Advisory Graduate Student

1.      1.   MSc. Student (Mrs. Sanjana Seyeda),

          Project: Epithelial to Mesenchymal Transition and Lung Disease: a 3 dimensional approach     October 2017-October 2019

1.      2.   MSc. Student (Mrs. Aida Feiz Barazandeh),

           Project: PEPCK and Leishmania and Importance of Bioenergetics                                      September 2017-September 2019

1.      3.   MSc. Student (Mr. Abdulah Ramadan),

           Project: Vasomotor Changes in the Striatum Associated with Levodopa-Induced Dyskinesia in Parkinsonian Rat Model   May 2017-September 2019

1.      4.   PhD. Student (Mrs. Niketa Sareen),

           Project: Allogeneic Mesenchymal Stem Cell Mediated Cardiac Regeneration     October 2015-September 2020

1.      5.   PhD. Student (Mr. Nagakannan Pandian),

           Project: Role of Thioredoxin system in regulation of cell death mechanisms after oxidative stress October 2015-September 2020

1.      6.   PhD. Student (Mrs. Jessica Jarmaz),

           Project: Epigenetic and FASD                                                                 October 2014-September 2019

Previous Supervisory and Co-Supervisory Trainee

1. MSc student (Mr. Javad Alizadeh) Supervisor.

                     Project: Autophagy and Modulation of Lung Cellular Phenotype in Non-Small Lung Cancer

                     January 2015-August 2017, Current Position: PhD student University of Vermont, USA.

        2. MSc student (Mr. Adel Rezaei Moghadam) Co-Supervisor.

                            Project: Autophagy/Unfolded Protein Response and Rhabdomyosarcoma treatment        

                        January 2016-May 2018, Current Position: Research Assistant, University of Manitoba, Winnipeg, Canada.

        3. MITACs Globalink International Intern Program (Mr. Mohammed Alsultan Albokashy, Supervision,       Project: Role of Mevalonate Cascade in Brain Tumor, June-September 2015, Current Position. Family Physician: Saudi Arabia.

                        4. MSc student (Mrs. Niloufar Ashtari) Co-supervisor with Dr. Hassan Marzban.

                      Project: Role MAPK Signaling in Development of Cerebellum in Nax mouse model. September  2014-May 2017, Current Position: Research Assitant, Sickkids Hospital, University of Toronto, Canada.

5. PhD student (Ms. Parvaneh Mehrbod, UPM University of Malaysia). Co-Supervisor

                      Project: Consideration of Statins in H1N1 Infection, January 2010-2014, Current Position: Faculty                   member, Iran Institute of Pasture.

                     6. PhD Student (Dr. Peyman Peymani, Shiraz Medical University). Project Leader

                   Project: Role of Autophagy/Apoptosis/ER-Stress in Viral Hepatitis C  September 2011-September 2015, Current Position, Assistant Professor, Health Policy Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.

  7.  Undergraduate summer student (Ms. Anna Serebrin) in the laboratory of Dr. Andrew J. Halayko.

                       Project: Autophagy regulation of TGF-induced Fibrosis in airways. Summer 2009. Current Position: Internal Medicine Specialist.

     8.  Summer student (Mr. Hasan Pirzadeh) in the laboratory of Dr Marek Los. Project: Death signaling pathway of S100A8/A9 in neuroblastoma. Summer 2006. Current position: Family Physician, Winnipeg, Manitoba.

     9.  MD fellow in Ophthalmology (Dr. Mahmoud Kazemi). Project: Role of Alpha 1 antitrypsin phenotypes in Uveitis patients in South East Iran. 1996-1998. Current Position: Passed Away in car accident.

    10.  MD fellow in Ophthalmology (Dr. Mahmoud Mobaleghi). Project: Role of Alpha 1 antitrypsin phenotypes in VKC patients in South East Iran. 1997-1999, Current Position: Pro Khorfessor of Ophthalmology, Khorram Abad University, Iran.

Laboratory courses, Certifications

• Cell Death Training Workshop, July 2008, European APOTRAIN program, Marie Curie Research Program, University of Ulm, Ulm, Germany.

• Presentation Skills workshop, January 2007-March 2007, University of Manitoba, Winnipeg, Canada.

• Principles of Microscopy and Imaging, November 2006, Innovative Technologies in Multidisciplinary Health Research Training (ITMHRT), Winnipeg, Canada.

• Teaching Competency, Sept 1993-March 1996, Teaching Competency Program , Tarbiat Modarres University, Tehran, Iran. 

  Journal Editor and Reviewer

• Reviewer of The Prostate                                                                                          September 2010-Present

• Reviewer of PLOS ONE                                                                                            September 2010-Present

• Reviewer of Autophagy                                                                                             September 2010-Present

• Reviewer of Biomedical Pharmacology                                                                     January 2010-Present

• Reviewer of Journal of Cellular and Molecular Medicine                                           February 2010-Present

• Reviewer of Diabetic Research and Clinical Practice                                                February 2009-Present

• Reviewer of Respiratory Research                                                                            January 2012-Present

• Reviewer of Current Gene Therapy                                                                           April 2012-Present

• Reviewer of Iranian Journal of Asthma and Allergy                                                   April 2012-Present

• Reviewer of Carcinogenesis                                                                                      September 2013-Present

• Reviewer of Cellular and Molecular Life Science                                                      April 2012-Present

• Reviewer of Cell Death and Disease                                                                         September 2012-Present

• Reviewer of Cell Proliferation                                                                                    January 2010-Present

• Reviewer of BMC Cancer                                                                                          January 2010-Present

• Reviewer of Iranian Biomedical Journal                                                                    October 2004-Present

• Reviewer of Molecular Biology Report                                                                      December 2012-Present

• Reviewer of Molecular and Cellular Biochemistry                                                     February 2013-Present

• Reviewer of Canadian J. Physiology & Pharmacology                                             September 2014-Present

• Reviewer of Oncotarget                                                                                            August 2015-Present

• Associate Editor of Hepatitis Monthly                                                                        April 2002-Present

• Advisory Board of OA Molecular and Cell Biology                                                    December 2012-Present

• Editor of Gene, Cell, Tissue                                                                                      November 2013-Present

• Editorial Board of Pharmacologia                                                                             December 2013-Present

• Editorial Board of Open Journal of Respiratory Diseases                                         February 2014-Present

• Commission Editor of Fibrogenesis and Tissue Repair                                             February 2014-Present

• Academic Editor of PLOS ONE                                                                                  August 2014-Present

  Journal Guest Editor

• Invited Guest Editor for a Volume of Current Medicinal Chemistry-Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry "S100A8/A9 in Inflammation and Cancer.“                         Published December 2009

• Invited Guest Editor for a Volume of Current Medicinal Chemistry-Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry “Alpha-1 Antitrypsin in Liver and Lung Diseases.”              Published December 2010

• Invited Guest Editor for a Volume of Hepatitis Monthly “ Hepatocellular Carcinoma.”  Published October 2012

• Invited Guest Editor for a Volume of Current Molecular Pharmacology "Mevalonate Cascade in Lung Disease, Cardiovascular Diseases and Cancer“.                                                     Published January 2017 and April 2017

  Funding Agency Grant and Fellowship Reviewer

• Reviewer for Science Foundation of Ireland (SFI)                                                  January 2012-Present

• Reviewer for The Research Foundation Flanders (FWO)                                      January 2012-Present

• Reviewer Panel for Graduate Student Studentship Award (Research Manitoba)   March 2015-Present

• Reviewer India Alliance Fellowship                                                                         January 2017-Present

• Patents and Intellectual Property Rights

  Saeid Ghavami, Ahmad Asoodeh, Hossain Naderi-Manesh, Marek Los: "Anticancer, antimicrobial and immuno-suppressive properties of Brevinin-like peptides from Rana Ridibunda." (PCT/US60/686,414).

  Pending and Under-review: Behzad Yeganeh, Saeid Ghavami, Andrew J Halayko, Kevin Coombs: “Application of Bafilomycin A as an antiviral drug” (submitted to University of Manitoba Technology Transfer Office).

  Teaching Experiences

       1. Biomedical Skill Training for Graduate Student: 2014-Peresent, University of Manitoba, Canada

       2. Lung Histology for Medical School first year students: 2015-Peresent, University of Manitoba, Canada

       3. Lung Gross Lab Anatomy for Medical School first year students: 2017-Peresent, University of Manitoba, Canada

       4. Biochemistry Lab for undergraduate Student: 2009, 2010, University of Winnipeg, Canada

       5. General Biochemistry for Medical School, midwifery, nursery, dentistry, and lab biotechnology students: 1995-2004, Zahedan Medical University, Iran.   

  Most Significant Contribution to Research

  Contribution #1: Identifying the Role of Autophagy in Regulation of Cellular Response to Stress  

  I have been investigating how autophagy maintains cellular hemostasis under stress conditions to help cell survival, and have successfully addressed fundamental questions in this field. I showed that autophagy actively cross-talks with several different mechanisms that determine cell viability, including apoptosis and unfolded protein response. I have shown that autophagy is the major determinant in regulating cell viability under stress conditions and that it can regulate cell death by positive or negative regulation of apoptosis. In a recent investigation my group has showed that TiO2 nanoparticle induced reactive oxygen-induced cell death which is tightly regulated by autophagy. My group has also shown that autophagy is involved in physiological cycle of hepatitis virus B and C infection and replication in human liver biopsies and infected patients. As a post-doctoral fellow I also showed that the Bcl2 protein family can regulate cross-talk of autophagy, apoptosis, and unfolded protein response in the lung and heart mesenchymal cells, and in different epithelial cells. My investigations also showed that autophagy clears damaged cellular organelles during cellular stress, which usually prevents extreme cellular death via apoptosis and provides the best chance for cellular survival. Recently, I led international teams of expert and prepared two book chapter on the regulation of autophagy by unfolded protein response, and importance of autophagy in cerebellum development (article#8) which has been published by the Elsevier and springer publishing group. 

  Contribution #2: Regulation of lung the cellular Phenotype by Autophagy

  After establishing my independent research program, my group has focused on the mechanisms involved in regulation of changes of lung epithelial mesenchymal phenotypes. Our investigations have shown that autophagy and unfolded protein response (article #3) are essential steps in regulation of lung cellular phenotype. Based on my group recent investigations about the role of autophagy in regulation of the cellular phenotype, we have addressed proper conditions for chemical inhibition of autophagy (Bafilomycin A1) in latest autophagy monitoring guideline. 

  Fibroblasts have an important function in providing a suitable response for different organelle adaptation to environmental stress. One of these responses, fibrosis, is involved in wound healing. Fibroblast-to-myofibroblast conversion is involved in the mechanism of fibrosis. As a postdoctoral trainee I have provided novel evidence that autophagy is a regulator for fibronectin and collagen Iα2 biosynthesis in both lung and heart.

  Contribution #3: Development of Methods in Cell Biology

  Since establishment of my research group, one of my major aims of research program is development of cell biology protocols which can be widely used by researchers and trainees. My HQPs have been actively involved in developing such protocols which closely related to their research training program. We (including my MSc HQPs and PDF HQP) have been able to develop a unique sensitive method for simultaneous detection of autophagy and EMT in lung epithelial cells (article #1) and measurement of small Rho GTPase activity in different types of cells. Both of these model is modified and developed so can be done with minimal equipment with highest sensitivities. I have also developed/modified using autophagy inhibitors in the latest guideline for autophagy, which is highly appreciated in autophagy community. As a member of autophagy community, I have also been involved in 2012 guidelines of autophagy protocol which broadly address the detection methods for autophagy.      

  Contribution #4: Cholesterol Metabolism Pathway and cell death mechanisms:

  My investigations have addressed the mechanism that is involved in regulation of cholesterol metabolism inhibition induced cell death in more than 20 models of cells. In 2017, I edited of two volumes of Current Molecular Pharmacology (January, April) focusing on mevalonate cascade in health and diseases. 

Full Length Manuscripts in Preparation:

1. Ghavami S, Mutawe MM, Serebrin A, Yeganeh B, Sharma P, Kashani HH, Basu S, Jha A, McNeill KD, Klonisch T, Cunnington RH, Dixon I, Nachtigal MW, Halayko AJ. TGF-β1 Induced Fibrosis is Regulated by non-smad dependent Autophagy in Human Airway Mesenchymal Cells. Will be submitted to Cell Res, December 2018.

1. Ghavami S, Ande SR, Mehrpour M, Milani B, Sharma P, Mutawe MM, Kroeker A, Kashani H, Yeganeh B, Schaafsma D, Hashemi M, Halayko AJ, Apoptosis-Autophagy cross talk: role of p53 and bcl2 family members. Will be submitted to American J Physiol. Cell Physiol (Invited Review). September 2018.

1. Ghavami S, Mutawe MM, Vogl T, Kerkhoff C, Chazin WJ, Roth Y, Halayko AJ. Mechanism of S100A8/A9-induced Airway Remodeling. Will be submitted to J. Leuok. Biol, November 2018.

1. Yeganeh B, Zeki AA, Shojaei, Kenyon N, Halayko AJ, Knight DA, Ghavami S. Apoptosis, Autophagy, and Unfolded Protein Response in Idiopathic Pulmonary Fibrosis, a case control study. Will be submitted to Thorax, September 2018.

Submitted or Under-Revision Referred Article:

1. Yeganeh B, Peymani P, Rezaei Moghadam A, Wiechec E, Alavian SM, Hashemi M, Gramizadeh B, Lankarani KB, Post M, Coombs K, Ghavami S. Apoptosis, Autophagy, and Endoplasmic Reticulum Stress in Autoimmune Hepatitis. 2018, Submitted to World Journal of Herpetology (Under Revision, Impact Factor 3.2).

1. Ojo OO, Basu S, Jha A, Ryu MH, Mahood TH, Ghavami S, Schwartz J, Chakir J, Laviolette M, Doeing D, McConville J, Vogl T, Roth J, Halayko AJ. Alarmin S100A8/A9 Promotes Pathophysiological Hallmarks of Allergic Asthma. 2017, American Journal of Respiratory and Critical Care Medicine (Under Revision, Impact Factor 10.5).

1. Los MJ, Ghavami S. Autophagy Changes the Phenotype of Mouse Embryo Fibroblasts (MEF). July 2017, Autophagy (Under Revision).

1. Alizadeh J, Shojaei S, Da Silva S, Rezaei Moghadam A, Hashemi M, Los MJ, Zeki A, Gordon JW, Ghavami S. Detection of Small GTPase Activity. 2018, Journal of visualized experiments: JoVE, (Under Revision, Impact Factor 1.6).

1. Mousavi Gargari SL, Mostafavi Z, Barazesh M,. Ashktorab H, Ramezani A, Mohamadi S, Ghavami S, Mokarram P. A Comparison between Cell, Protein and Peptide-Based Approaches for Selection of Nanobody Against CD44 from a Synthetic Library. 2017, Biotechnology Letters (BILE-D-17-01097, Under Revision).

1. Zeglinski MR, Rezaei Moghadam A., Ande SR., Sheikholeslami K, Mokarram P, Sepehri Z, Rokni H, Khadem Mohtaram N, Poorebrahim M, Masoom A, Toback M, Sareen N, Saravanan S, Jassal DS,  Hashemi M, Marzban H, Singal P, Wigle JT, Czubryt MP, Akbari M, Dixon IM^¥, , Ghavami S^¥, Gordon JW^¥, Dhingra S^¥. Myocardial Cell Signaling during the Transition to Heart Failure. 2018, Comprehensive Physiology (CPHY-17-0053, Under Revision) (Share co- senior authorship, Impact Factor 6.9).

1. Shojaei S, Alizadeh A, Koleini N, Samie E, Albokashi M, Xue F, Islam I, Thliveris J, Kardami E, Hatch G, Eftekharpour E, Hombach Klonisch, Akbari M, Klonisch T, Ghavami S. Mevalonate Cascade Inhibition Increases Temozolomide Induced Apoptosis in Glioblastoma Tumor Cells: A 2D and 3D study. 2018, Cell Death & Differentiation (Under Review, Impact Factor 8.2).

1. Rezaei Moghaddam A, da Silva Rosa S, Samie E, Thliveris J, Akbari M, Ghavami S^¥, Gordon JW^¥. Temozolomide Induces Apoptosis in Rhabdomyosarcoma Cell is Regulated via Autophagy Pathway: A 2D and 3D study. 2018, Cell Death & Disease (Will be submitted 15 July 2018, share co senior authorship, Impact Factor 5.9).

1. Emami A, Shojaei S, da Silva Rosa S, Samie E, Kalantari F, Thliveris J, Akbari M, Gordon GW^¥, Ghavami S^¥. Mevalonate Cascade Inhibition Induces Apoptosis in Rhabdomyosarcoma and C2C12 cells via Differential Autophagy Pathway Modulation: A 2D and 3D cell culture study. 2018, Cell Death Discovery (Under Review, share co-senior authorship). 

1. Mirani B, Pagan E, Duchscherer, J, Toyota BD, Ghavami S, Akbari M. A 3D Bioprinted Hydrogels Mesh Loaded with All Trans Retinoic Acid for Treatment of Glioblastoma Multiforme. 2018, Journal of Control Release (Under Review, Impact Factor 7.8).

1. Alizadeh J, Ghavami S. Autophagy and Epithelial to Mesenchymal Transition in Cancer. 2018, Critical Reviews in Oncogenesis, (Invited Article, Will be submitted 15 June 2018).

1. Amiri S, Dastghaib S, Ahmadi M, Los MJ. Sepanjnia A, Dalvand A, Rastegar M, Madrakian T, Mokarram P, Ghavami S. Betulin and its Derivates as Novel Compounds with Antimicrobial, anti-HIV, and Anticancer Activities. 2018. Biotechnology Advances. (Invited Article, Will be submitted 30 July 2018 Impact Factor 10.6).

1. Ashtari N, Rahimi Balaei M, Xiadon J, Shabanipour S, Eissa, N, Chung SH, Vriend J, Gia JE, Del Bigio MR, Ghavami S, Marzban H. Reelin Pathway Impairment Affects Purkinje Cell Migration in Lysosomal Acid Pohsphatase (Acp2) Mutant Mice Cerebellum. 2018, Cellular & Molecular Life Science (Under Review, Impact Factor 5.8).

1. Dalvand A, Dastghaib S, Sepanjnia A, Alizadeh J, Behrouj M, Kiumarsi M, Mokarram P, Sharma P, Zeki AA, Ghavami S. Unfolded Protein Response and Lung Disease. 2018, Clinical and Translational Medicine (Invited Article, Will Be Submitted 15 July 2018). 

1. Tarricone E, Di Stefano A, Brun P, Ghavami S, Leonardi A. Possible Autophagy induction in Vernal Keratoconjunctivitis via Tumor Necrosis Factor Alpha Stimulation. 2018, Autophagy (Will be submitted September 2018).

1. McAlinden KD, Xenaki D, Deshpande D, Sohal SS, Ghavami S, Oliver BG, Haghi M, Sharma P. Autophagy is selectively activated and correlates with airway remodeling in asthma: insights from both human and murine disease models. 2018, Cell Death & Disease (Under Review).

1. Nikseresht M, Shahverdi M, Dehghani M, Adibi H, Mohammadi R, Ghalamfarsa G, Ghavami S. Association of SNP ATG5 gene polymorphism rs2245214 with susceptibility to non-small cell lung cancer. 2018, J Cell Biochem (Under Review, JCB-18-0806).

Full Length Manuscripts in Refereed Journals (2004-2018) (Scopus:>6800 citations, h- index: 33, Google Scholar > 11,400citations, h-index:39):

1. Hashemi M, Bahari G, Markowski J, Małecki A, Los MJ, Ghavami S. Association of PDCD6 Polymorphisms with the Risk of Cancer: Evidence from a Meta-Analysis. 2018, Oncotarget (In Press, Impact Factor 5.1). 

1. Kavousipour S, Mokarram P, Gargari SLM, Mostafavi-Pour Z, Barazesh M, Ramezani A, Ashktorab H, Mohammadi S, Ghavami S. A Comparison between Cell, Protein and Peptide-Based Approaches for Selection of Nanobodies against CD44 from a Synthetic Library. 2018, Protein Pept Lett. doi: 10.2174/0929866525666180530122159. [Epub ahead of print].

1. Hashemi M, Bahari G, Bizhani F, Danesh H, Sharhadi S, Ziaee SAM, Basiri A, Taheri M, Ghavami S. Evaluation of 4-bp insertion/deletion polymorphism within the 3'UTR of SGSM3 in bladder cancer using mismatch PCR-RFLP method: A preliminary report. 2018, J. Cell. Biochem. doi: 10.1002/jcb.26764. [Epub ahead of print].  (Impact Factor 3.2).

1. Alizadeh J, Glogowska A, Thliveris J, Kalantari F, Shojaei S, Hombach-Klonisch S, Klonisch T, Ghavami S. Autophagy Modulates Transforming Growth Factor beta 1 Induced Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells. 2018, Biochim Biophys Acta, Mol. Cell Res.1865(5):749-768. doi: 10.1016/j.bbamcr.2018.02.007 (Impact Factor 5.3).

1. Sharifzad, F, Ghavami S, Mardpour S, Mollapour M, Azizi Z, Taghkhani A, Los MJ, Fakharian E, Ebarahimi M, Hamidieh AA. Glioblastoma cancer stem cell biology: Potential theranostic targets. 2018, Drug Resistance Update (Accepted, In Press, Impact Factor 10.9).

1. Ahmadi M, Madrakian T, Ghavami S. Preparation and Characterization of Simvastatin Nanocapsules: Encapsulation of Hydrophobic Drugs in Calcium Alginate. 2018, Methods Mol Biol (In Press).

1. Sepehri Z, Arefi D, Mirzaei N, Afshari A, Kiani Z, Sargazi A, Panahi Mishkar A, Owaysee Oskoee H, Masjedi M, Ghavami S. Changes in serum level of trace elements in pulmonary tuberculosis patients during anti-tuberculosis treatment. 2018, Journal of Trace Elements in Medicine and Biology, (In press).

1. Hashemi M, Bahari G, Sarhadi S, Eskandari E, Narouie B, Taheri M, Ghavami S. 4-bp insertion/deletion (rs3783553) polymorphism within the 3'UTR of IL1A contributes to the risk. 2018, J. Cell. Biochem. 119(3):2627-2635. doi: 10.1002/jcb.26427(Impact Factor 3.1).

1. Hombach-Klonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamaei A, Siemianowicz K, Likus W, Wiechec E, Toyota BD, Hoshyar R, Seyfoori A, Sepehri Z, Ande AR, Khadem F, Akbari M, Gorman A, Samali A, Klonisch T, Ghavami S. Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response. 2018,  Pharmacology & Therapeutics, 184:13-41. doi: 10.1016/j.pharmthera.2017.10.017 (Impact Factor, 11.1, 1 citations). 

1. Ghavami S, Yeganeh B, Zeki AA, Shojaei S, Kenyon NJ, Ott S, Samali A, Patterson J, Alizadeh J, Rezaei Moghadam A, Dixon IMC, Unruh H, Knight DA, Post M, Klonisch T, Halayko AJ. Autophagy and the Unfolded Protein Response Promote Pro-fibrotic Effects of TGFb₁in Human Lung Fibroblasts. Am. J. Physiol.-Lung Cell. Physiol., 2018
   314(3):L493-L504. doi: 10.1152/ajplung.00372.2017  (Impact Factor 4.8, 3 citations).

1. Yeganeh B, Ghavami S, Niaz RA, Klonisch T, Halayko AJ, Coombs KM. Autophagy activation is required for influenza A virus-induced apoptosis and replication. 2018, BBA-Mol. Cell Res. 1865(2):364-378. doi: 10.1016/j.bbamcr.2017.10.014 (Impact Factor 5.3).

1. Alizadeh J, Shojaei S, Sepanjnia A, Hashemi M, Eftekharpour E, Ghavami S. Simultaneous Detection of Autophagy and Epithelial to Mesenchymal Transition in the Non-small Cell Lung Cancer Cells. 2017, Metthods Mol. Biol. doi: 10.1007/7651_2017_84. [Epub ahead of print (1 citation)].

1. Hassanzarei S, Hashemi M, Sattarifard F, Hashemi SM, Bahari G, Ghavami S. Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population. 2017,Toumor Biol. Oct;39(10):1010428317727539. doi: 10.1177/1010428317727539 (Impact Factor 3.3).

1. Thanasupawat T, Natarajan S, Rommel A, Bergen H, Krcek J, Pitz M, Beiko J, Ghavami S, Krawits S, Verma IM, Klonisch T, Hombach-Klonisch S. Dovitinib enhances temozolomide efficacy in glioblastoma cells.2017, Molecular Oncology, 11(8):1078-1098 (Impact Factor 5.8).

1. Sepehri Z, Arefi D, Mirzaei N, Sargazi A, Mishkar AP, Sargazi A, Kiani Z, Ghavami S. Essential and Toxic Metals in Serum of Individuals with Pulmonary Tuberculosis in an endemic region. 2017, Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 6, pp. 8-13.

1. Cieślar-Pobuda A, Knoflach V, Ringh MV, Stark J, Likus W, Siemianowicz K, Ghavami S, Hudecki A, Green JL, Los MJ. Transdifferentiation and reprogramming: Overview of the processes, their similarities and differences. 2017, BBA-Mol. Cell Res., 1864(7):1359-1369. doi: 10.1016/j.bbamcr.2017.04.017 (Impact Factor 5.3, 2 citations).

1. Sepehri Z, Kiani Z, Afshari M, Kohan F, Dalvand A, Ghavami S. Inflammasomes and type 2 diabetes: An updated systematic review. 2017, Immun. Letter, 192:97-103. doi: 10.1016/j.imlet.2017.10.010. [Epub ahead of print] (Impact Factor 2.9, 1 citaiton).

1. Hashemi M, Amininia S, Ebrahimi M, Simforoosh N, Basiri A, Ziaee SAM, Narouie B, Sotoudeh M, Mollakouchekian MJ, Maleki ER, Hanafi-Bojd M, Rezaei M, Eskandari-Nasab E, Taheri M, Ghavami S. Association between polymorphism in TP53 and MDM2 gene and susceptibility to prostate cancer. 2017, Oncology Letter, 13(4):2483-2489. doi: 10.3892/ol.2017.5739 (5 citations).

1. Sepehri Z, Kiani Z, Kohan F, Alavian SM, Ghavami S. Toll like receptor 4 and hepatocellular carcinoma; A systematic review. 2017, Life Science, 179:80-87. doi: 10.1016/j.lfs.2017.04.025 (Impact Factor 2.9, 1 citation).

1. Gholizadeh S, Draz M, Zarghooni M, Sanati Nezhad A, Ghavami S, Shafiee H, Akbari M. Microfluidic Approaches for Isolation, Detection, and Characterization of Extracellular Vesicles: Current Status and Future Directions. 2017, Biosensors and Bioelectronics, 15;91:588-605. doi: 10.1016/j.bios.2016.12.062 (Impact Factor 7.9, 15 citations).

1. Rezaei Moghadam A, Tafsiri A, Patrad E, Lovick D, Pluard T, Salacz M, Peng W, Fangman B, Maz M, Shah K, Ricke B, Bi D, Kimura K, Yoder M, Graves L, Khajoie Nejad M, Sanaat Z, Tavakolinia N, Yazdi M, Mazani M, Ghavami S, Naima Z, Reilly C, Esfandyari T, Farassati F. Ral Signaling Pathway in Health and Cancer. 2017, Cancer Medicine. 6(12):2998-3013 (Impact Factor 3.4).

1. Chaabane W, Ghavami S, Małecki A, Los MJ. Human-Gyrovirus-Apoptin interferes with the cell cycle and induces G2/M arrest prior to apoptosis. 2017, Arch Immunol Ther Exp (Warsz). 2017 Apr 6. doi: 10.1007/s00005-017-0464-8. [Epub ahead of print] (Impact Factor 2.9, 2 citations). 

1. Alizadeh A, Zeki AA, Mirzaei N, Badbezanchi I, Rezaei Moghadam A, Glogowska A, Pandian N, Eftekharpour E, Tewary S, Gordon J, Xu FY, Field JT, Weichec E, Yuneda KY, Keynon NJ, Hashemi M, Hatch G, Hombach Klonisch S, Klonisch T, Ghavami S. Mevalonate Cascade Inhibition with Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in a Broad Range of Tumor Cells. 2017, Scientific Reports, 27;7:44841. doi: 10.1038/srep44841 (Impact Factor 4.3, 3 citations).

1. Zeki AA, Yeganeh B, Kenyon NA, Ghavami S. Editorial: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part II). 2017, Current Molecular Pharmacology, 2017;10 (2):74-76. doi: 10.2174/187446721002170301204357.

1. Ghavami S, Yeganeh B, Kenyon NA, Zeki AA. Editorial: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part 1). 2017, Current Molecular Pharmacology, 10(1):3-5. doi: 10.2174/1874467209999160114145952..

1. Mokarram P, Albokashy MS, Zarghooni M, Sepehri Z, Chen QM, Hudecki A, Sargazi A, Alizadeh J, Rezaei Moghadam A, Hashemi M, Movassagh H, Klonisch T, Owji AA, Los MJ, Ghavami S. New Frontier in the Treatment of Colorectal Cancer: Autophagy and Unfolded Protein Response as Targets. 2016, Autophagy, 13(5):781-819. doi: 10.1080/15548627.2017.1290751 (Impact Factor 8.75, 9 citation).

1. Sepehrimanesh M, Peymani P, Lankarani KB, Ghavami S. Serum autophagy-related protein 7 as a diagnostic biomarker of disease activity in patients with ulcerative colitis. 2016, Scandinavian Journal of Gastroenterology, 52(4):468. doi: 10.1080/00365521.2016.1259655 (Impact Factor 2.6, 1 citation).

1. Hashemi M, Bizhani F, Danesh H, Narouie B, Sotoudeh M, Radfar MH, Honarkar Ramazani M, Bahari G, Taheri M, Ghavami S. MiR-608 rs4919510 C>G polymorphism increased the risk of bladder cancer in an Iranian population. 2016, AIMS Genetics, 3 (4): 212-218. doi: 10.3934/genet.2016.4.212.  

1. Mousavi MA, Sharifi M, Moasses Ghafary S, Khataee A, Mohammadalipour M, Rahmati M, Hajjaran S, Los MJ, Klonisch T, Ghavami S. Photodynamic N-TiO₂ Nanoparticle Treatment Induces ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells. 2016, Scientific Reports, 6:34413. doi: 10.1038/srep34413 (Impact Factor 4.3, 11 citations).

1. Gupta S, Zeglinski M, Rattan SG, Landry N, Ghavami S, Halayko AJ, Dixon IM. Inhibition of autophagy inhibits the conversion of cardiac fibroblasts myofibroblasts.2016, Oncotarget, doi: 10.18632/oncotarget.12392. [Epub ahead of print](Impact Factor 5.1, 2 citation).

1. Pandian N, Iqbal MA, Yeung A, Thliveris JA, Rastegar M, Ghavami S, Eftekharpour E. Aggravation of oxidative stress after TrxR deficiency in neurons interrupts autophagic flux through differential processing of lysosomal cathepsins. 2016, Free Radical Biology and Medicine, (http://dx.doi.org/10.1016/j.freeradbiomed.2016.09.026, in Press) (Impact Factor 5.7, 3 citations).

1. Hashemi M, Moradi N, Rezaei M, Ziaee SAM, Naroui B, Sotoudeh M, Bahari G, Ghavami S. Association between epidermal growth factor receptor 4 gene polymorphisms and the risk of prostate cancer in a sample of the Iranian Population. 2016, Cellular and Molecular Biology, 62(10): 43-8.

1. Cieślar-Pobuda A, Rafat M, Knoflach V, Skonieczna M, Hudecki A, Urasińska E, Ghavami S, Los MJ. Human induced pluripotent stem cell differentiation and direct transdifferentiation into corneal epithelial-like cells. 2016, Oncotarget (7(27):42314-42329. doi: 10.18632/oncotarget.9791 (Impact Factor 5, 9 citations).

1. Peymani P, Ghavami S, Yeganeh B, Tabrizi R, Sabour S, Geramizadeh B, Fattahi MR, Ahmadi SM, Lankarani KB. Effect of chloroquine on some clinical and biochemical parameters in non-response chronic hepatitis C virus infection patients: pilot clinical trial. 2016, Acta Biomed.6;87(1):46-53.

1. Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, Ghavami S, Arab SE, Rezaei Moghadam A, Amiri M. How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. 2016, Hep Mon, 16(2):e36005. doi: 10.5812/hepatmon.36005. eCollection 2016 (Impact Factor 1.7, 10 citations).

1. Peymani P, Yeganeh B, Sabour S, Geramizadeh B, Fattahi MR, Keyvani H, Azarpir N, Coombs KM, Ghavami S, Lankarani KB. New utilization of an old drug: Chloroquine reduces viral and ALT levels in HCV non-responders. 2016, Canadian Journal of Physiology and Pharmacology, 94(6):613-9. doi: 10.1139/cjpp-2015-0507 (Impact Factor 1.9, 1 citations).

1. Akbari-Birgani S, Paranjothy T, Zuse A, Janikowski T, Cieślar-Pobuda A, Likus W, Grabarek J, Schweizer F, Ghavami S, Klonisch T, Los MJ. Cancer stem cells/cancer-initiating cells and methods of their detection, 2016, Drug Discovery Today, 21(5):836-42. doi: 10.1016/j.drudis.2016.03.004 (Impact Factor 6.4, 24 citations).

1. Zeglinski MR, Davies J, Ghavami S, Rattan S, Halayko AJ, Dixon IMC. Chronic Expression of Ski Induces Apoptosis and Represses Autophagy in Cardiac Myofibroblasts. 2016. BBA - Molecular Cell Research, (1863(6 Pt A):1261-8. doi: 10.1016/j.bbamcr.2016.03.027 (Impact Factor 5.3, 2 citations).

1. Hashemi M, Sanaei S, Rezaei M, Bahari G, Hashemi SM, Mashhadi MA, Taheri M, Ghavami S. miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation. Experimental Oncology, 38(1):57-9 (4 citations).

1. Jain MV, Shareef A, Linkus W, Ghavami S, Los MJ. Inhibition of miR301 enhances Akt mediated cell proliferation by accumulating PTEN in the nucleus. 2016, Oncotarget (;7(15):20953-65. doi: 10.18632/oncotarget.7996 (Impact Factor 5.1, 7 citations)

1. Sanaei S, Hashemi M, Rezaei M, Hashemi S, Bahari G, Ghavami S. Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk. 2016, Biomedical Reports, 5(1):125-129.

1. Klionsky DJ, Abbadie C, Abdalla FC, ……., Ghavami S,………, Zucchini-Pasxcal N, Zuckerbraun B. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3^rd edition). 2016, Autophagy, 12 (1): 1-222 (Impact Factor 8.75, >500 citations).

1. Iranpour M, Rezaei Moghadam A, Yazdi M, Ande SR, Alizadeh J, Wiechec E, Lindsey R, Drebot M, Coombs KM, Ghavami S. Apoptosis, Autophagy, and Unfolded Protein Response Pathways in Arbovirus Replication and Pathogenesis: Involvement of Apoptosis, Autophagy and Unfolded Protein Response. 2016, Expert Reviews in Molecular Medicine, 18:e1. doi: 10.1017/erm.2015.19 (Impact Factor 4.4, 8 citations).

1. Linkus W, Siemianowicz K, Bieńk K, Pakuła M, Pathak H, Dutta C, Wang Q, Shojaei S, Ghavami S, Cieślar-Pobuda A, Los MJ. Mevalonate signaling cascade and (cancer) cell stemness. 2016, Drug Resistance Update, 25:13-25. doi: 10.1016/j.drup.2016.02.001 (Impact Factor 10.9, 119 citations).  

1. Rahimi Balaei M, Jiao X, Ashtari N, Afsharinezhad P, Ghavami S, Marzban H. Cerebellar Expression of the Neurotrophin Receptor p75 in Naked-Ataxia Mutant Mouse. 2016, International Journal of Molecular Science, 17(1). pii: E115. doi: 10.3390/ijms17010115 (Impact Factor 3.3, 1 citation).

1. Zeki AA, Yeganeh B, Post M, Kenyon N, Ghavami S. Autophagy in Airway Diseases: A New Frontier in Human Asthma? 2016, Allergy 71(1):5-14. doi: 10.1111/all.12761(Impact Factor 6, 11 citations).

1. Yeganeh B, Peymani P, Rezaei Moghadam A, Alizadeh J, Wiechec E, Alavian SM, Hashemi M, Gramizadeh B, Lankarani KB, Post M, Coombs K, Ghavami S. Apoptosis, Autophagy, and Endoplasmic Reticulum Stress in HCV and HBV Induced Hepatitis. 2015, World Journal of Gastroenterology, 21(47): 13205-13225-1339 (Impact Factor 3.3, 14 citations).

1. Shojaei S, Ghavami S, Panjehshahin MR, Owji AA. Comparison of the effects of ethanol on the expression levels of various mRNA isoforms of BDNF and their encoded protein in the hippocampus of adult and embryonic rats. 2015, International Journal of Molecular Science, 16(12):30422-37. doi: 10.3390/ijms161226242 (Impact Factor 3.3, 1 citation).

1. Hashemi M, Sanei S, Mashahdi MA, Hashemi SM, Taheri M, Ghavami S. Association study of hsa-mir-603 rs11014002 polymorphism and risk of breast cancer in a sample of Iranian population. 2015, Cellular and Molecular Biology (France, 61(8):69-73.

1. Cieślar-Pobuda  A, Vilas Jain  M, Kratz G, Rzeszowska-Wolny J, Ebrahimi M, Ghavami S, Wiechec E The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells. 2015, Oncotarget, 6(30):29753-70. doi: 10.18632/oncotarget.4995 (Impact Factor 5.1, 24 citations).

1. Vriend J, Ghavami S, Marzban H. The Role of the Proteasome in Cerebellar Development and Medulloblastoma. 2015, Molecular Brain, 8(1):64. doi: 10.1186/s13041-015-0155-5 (Impact Factor 4.3, 6 citations).

1. Rezaei Moghadam A, Tutunchi S, Namvaran Abbas Abad A, Yazdi M, Bonyadi F, Mohajeri D, Mazani M, Marzban H, Los MJ, Ghavami S. “Pre-administration of Turmeric Prevents Methotrexate-Induced Liver Toxicity and Oxidative Stress”. 2015, BMC Complement. Altern, Med. doi: 10.1186/s12906-015-0773-6 (Impact Facotr 2.1, 16 citations).

1. Hashemi M, Yousefi J, Hashemi SM, Amininia S, Ebrahimi M, Taheri M, Ghavami S. Association between programmed cell death 6 interacting protein insertion/deletion polymorphism and the risk of breast cancer in a sample of Iranian population. 2015, Disease Marker, 854621. doi: 10.1155/2015/854621 (Impact Factor 2.1, 4 citations).

1. Ghavami S, Cunnington RH, Gupta S, Yeganeh B, Filomeno KL, Freed DH, Chen S, Klonisch T, Halayko AJ, Singal R, Dixon IMC. Autophagy is a regulator of TGF-β1-induced pro-fibrotic effect in primary human atrial myofibroblasts.  2015, Cell Death & Disease, doi: 10.1038/cddis.2015.36 (Impact Factor 5.9,42 citations). 

1. Medapati MR, Dahlmann M, Ghavami S, Pathak A, Hoang-Vu C, Stein U, Hombach-Klonisch S. Exogenous S100A4 induces increased cell migration via interaction with RAGE in human thyroid cancer cells. 2015, Thyroid, ;25(5):514-2 (Impact Factor 4, 7 citations).

1. Thanasupawat T, Bergen H, Hombach-Klonisch S, Krcek J, Ghavami S, Del Bigio M, Krawitz S, Stelmack G, Halayko AJ, Meier M, Stetefeld J, Klonisch T. Right Handed Coiled Coil (RHCC) Nonotubes for Effective Platinium Mediated Killing of Human Glioblastoma Cells. 2015, Nonomedicine,  pii: S1549-9634(15)00038-6. doi: 10.1016/j.nano.2015.01.014. (Impact Factor 5.8, 11 citations).

1. Marzban H, Del Bigio M, Alizadeh J, Ghavami S, Zachariah R, Rastegar M. Cellular Commitment in the Developing and Adult Cerebellum. 2015, Frontiers in Cellular Neuroscience, 12;8:450. doi: 10.3389/fncel.2014.00450. (Impact Factor 4.3, 32 citations).

1. Hashemi M, Naderi M, Ebrahim M, Amininia S, Bahari G, Taheri M, Eskandari-Nasab E, Ghavami S. Association between interleukin-1 receptor antagonist (IL1RN) variable number of tandem repeats (VNTR) polymorphism and pulmonary tuberculosis in Zahedan, Southeast Iran. 2015, Ir. J. Asthma Allergy, 14(1):55-9 (Impact Factor 1.1, 15 citations).

1. Yeganeh B, Ghavami S, Klonisch, T, Halayko AJ, Coombs KM. Suppression of Influenza A Virus Replication in Human Lung Epithelial Cells by Non-cytotoxic Concentrations Bafilomycin. 2015, Am J Physiol Lung Cell Mol Physiol., 308(3):L270-86 (Impact Factor 4.8, 17 citations).

1. Hashemi M, Amininia S, Ebrahimi M, Hashemi SM, Taheri M, Ghavami S. “Association between hTERT polymorphisms and the risk of breast cancer in a sample of Southeast Iranian population”. 2014, BMC Res Notes, 10;7(1):895. (12 citations).

1. Rollano Peñaloza OM, Lewandowska M, Grabarek J, Stetefeld J, Ossysek K, Madej M, Bereta J, Sobczak M, Dulak J, Shojaei S, Griffith M, Ghavami S, Los MJ. Apoptin-cancer-slective Agents, Recent Advances. 2014, Trends Mol Med., 20(9): 519-528 (Impact Factor 10.7, 27 citations, co-senior authorship).

1. Amininia S, Hashemi M, Ebrahimi M, Mashhadi MA, Hashemi SM, Taheri M, Ghavami S. “Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of Southeast Iranian population”. 2014, Med. Oncolog., 31(10):189 (5 citations).

1. Chaabane W, Cieslar-Pobuda A, El-Gazzah M, Jain MW, Rzeszowska-Wolny J, Rafat M, Stettefeld J, Ghavami S, Los MJ., Human-Gyrovirus-Apoptin Triggers Mitochondrial Death Pathway-Nur77 is Required for Apoptosis Triggering. 2014, Neoplasia, 16(9):679-93 (Impact Factor 4.8, 20 citations).

1. Savelyeva A, Ghavami S, Asoodeh A, and M. Los. BrAn overview of brevinin superfamily: structure, function and clinical perspective. 2014, Adv. Exp. Med. Biol., 818:197-212.

1. Ghavami S, Gupta S, Hauch E., Hnatowich, M, Dixon IMC. Autophagy andHeart Diseases: Implications for Ischemia/Reperfusion Damage. 2014, Curr Mol. Chem., 14(5):616-29 (Impact Factor 3.3, 12 citations).

1. Hashemi M, Aminnia S, Ebrahimi M, Hashemi SM, Yousefi J, Eskandari-Nasab E, Taheri M, Ghavami S. “Association between LAPTM4B gene polymorphism and breast cancer susceptibility in an Iranian population”. 2014, Med. Oncolog, 31(8):111 (5 citations).

1. Yeganeh B, Wiechec E , Ande SR, , Sharma P, Freed D, Rezaei Moghaddam A, , Ande SR, Hashemi M,  Post M, Shojaei S, Zeki AA, Ghavami S. Targeting the Mevalonate Cascade as a New Therapeutic Approach in Cardiopulmonary Diseases and Cancer. 2014, Pharmacol. Therapeutic, 143(1):87-110 (Impact Factor 11.3, 59 citations).

1. Ghavami S, Sharma P, Yeganeh B, Oluwaseun, O, Jha A, Mutawe MM, Kashani HH, Los M, Klonisch T, Unruh H, Halayko H. Airway Mesenchymsl Cell Death by Mevalonate Cascade Inhibition: Integration of Apoptosis, Autophagy, and ER Stress. 2014, Biochim Biophys Acta., 843(7):1259-71 (Impact Factor 5.3, 20 citations).

1. Hombach-Klonisch S, Natarajan S, Thanasupawat T, Medapati M, Pathak A, Ghavami S, Klonisch T. Mechanisms of Therapeutic Resistance in Cancer (stem) cells). 2014, Front. Endocrinology,25;5:37 (12 citations).

1. Cieslar-Pobuda A, Back M, Rafat M, Ghavami S, Nilssen P, Los M. Differential fluorescence signal obtained by staining with various pentameric thiophene derivatives. 2014, Cytometry-A, 85(7):628-35 (Impact Factor 3.3, 15 citations).

1. Ghavami S, Shojaei S, Yeganeh B, Ande SR, Jangamreddy JR, Mehrpour M, Christoffersson J, Rezaei Moghadam A, Kashani H, Hashemi M, Owji AA, Los MJ. Autophagy and Apoptosis Dysfunction in Neurodegenerative Disease. 2014, Prog Neurobiol.,Jan;112:24-49 (Impact Factor 13.3, >250 citations).

1. Cunnington RH, Nothcott JM, Ghavami S, Bathe KL, Kavosh M, Davies J, Wigle JT, Dixon IMC. The Ski/Zeb2/Meox2 pathway provides a novel mechanism for Regulation of Cardiac myofibroblast Phenotype. 2014, J. Cell Sci.,1;127(Pt 1):40-9 (Impact Factor 5.3, 18 citations).

1. Wasik AM, Grabarek J, Pantovic A, Cieslar-Pbuda A, Asghari HR, Bundgaard-Nielsen C, Rafat M, Dixon IMC, Ghavami S, Los M. Reprogramming and Carcinogenesis-Parallels and Distinctions. 2014, Int Rev Cell Mol Biol.,308: 167-233 (co-correspondence author) (Impact Factor 4.3, 27 citations).

1. Hashemi, M, Fazaeli AA, Ghavami S, Eskandari Nasab E, Arbabi F, Mashahadi MA, Taheri M, Chaabane W, Jain MV, Los M. Functional polymorphisms of FAS and FASL gene and risk ofbreast cancer – pilot study of 134 cases. 2013, PLOS ONE, 8(1):e53075 (First equal authorship) (Impact Factor 2.9, 45 citations).

1. Jangamreddy JR, GhavamiS, Grabarek J, Fredriksson BA, Rao RK, Cieślar-Pobuda A, Panigrahi S, Los M.Salinomycin induced activation of autophagy, mitophagy and mitochondrial expansion: significance for cancer therapy development. 2013, Biochim Biophys Acta-Mol Cell Res. 1833(9):2057-69 (Impact Factor 5.3, 56 citations).

1. Gong C, Bauvy C, Tonelli G, Delomenie C, Nicolas V, Zhu Y, Domergue V, Marin-Esteban V, Delobos L, Gary H, Morel AP, Ghavami S, Song E, Codogno P, Mehrpour M. Self-renewal and tumorgenicity of Breast Cancer Stem Cells is Dependent on Beclin 1 and Autophagy. 2013, Oncogene, 32(18):2261-72 (Impact Factor 7.3, 101 citations).
2. Yeganeh B, Hashemi M, de Serres FJ, Los M, Ghavami S. Different Faces of Hepatocellular Carcinoma asa Health Threat in 21^st Century. 2013, Hep Month, 13 (2): e9308.

1. Yeganeh B, Rezaei Moghadam A, Tran A, Rahim MN, Ande SR, Hashemi M,Coombs KM, Ghavami S. Asthma & Influenza Virus Infection: Focusing on the Cell Death and Stress Pathways. 2013, Ir. J Asthma and Allergy, 12 (1): 1-17 (Impact Factor 1.3, 10 citations).

1. Yeganeh, B, Mukherjee S, Moir LM, Kumawat K, Kashani, HH, Baghchi RA, Baarsama HA, Gousens R, Ghavami S. Novel Non-canonical TGFβ Signaling Networks: Emerging roles in Airway Smooth Muscle Phenotype and Function. 2013, Pulmon. Pharmacol. Therapeutics, 26(1): 50-63 (Impact Factor 3.3, 25 citations).

1. Hashemi M, Hanafi-Bojd H, Eskandari-Nasab E, Bahari A, Narouie B, Taheri M, Ghavami S. Association of Adiponectin rs1501299 and rs 266729 gene polymorphisms with Nonalcoholic Fatty Liver Disease. 2013, Hepatitis Monthly, 13(5):e9527 (Impact Factor 1.7, 34 citations).

1. Ghavami S, Yeganeh B, Stelmack G, Kashani HH, Sharma P, Cunnington R, Ratan S, Bathe K, Klonisch T, Dixon I, Freed D, Halayko AJ. Apoptosis, Autophagy and ER Stress in Mevalonate Cascade Inhibition-Induced Cell Death of Human Atrial Fibroblasts. 2012, Cell Death Dis., 3:e330. Doi:10.1038/cddis.2012.61 (Impact Factor 5.9, 48 citations).

1. Ghavami S, Cunnington RH, Yeganeh B, Davies J, Rattan SG, Bathe K, Kavosh M, Los MJ, Freed DH, Klonisch T, Pierce GN, Halayko AJ, Dixon IMC. Autophagy Regulates Trans Fatty Acid-Mediated Apoptosis in Primary Cardiac Myofibroblasts. 2012, Biochim Biophys Acta-Mol Cell Res., 1823(12):2274-86 (Impact Factor 5.3, 19 citations).

1. Glogowska A, Stetefeld J, Weber E, , Ghavami S, Huang-Vu, K, Klonisch T.  Pro-EGF Cytoplasmic Domain Affects Erb Protein Degredation by the Lysoosmal and Ubiquitin-Proteosome in Human Thyroid Cancer Cells. 2012, Neoplasia, 14(5), 396-409 (Impact Factor 4.3, 15 citations).

1. Hashemi M, Bahari A, Hashemzehi N, Moazeni-Roodi S, Bakhshipour A, Ghavami S. Serum paraoxonase and arylesterase activities in Iranian patients with nonalcoholic fatty liver disease. 2012, Pathophysiology, 19(2):115-9.

1. Klionsky DJ, Abbadie C, Abdalla FC, ……., Ghavami S,………, Zucchini-Pasxcal N, Zuckerbraun B. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. 2012, Autophagy, 8 (4): 445-554 (Impact Factor 8.75, >2000 citations).

1. Kouhpayeh H, Hashemi M,  Hashemi SA, Moazeni-Roodi A, Naderi M, Sharifi-Mood B, Taheri M, Mohammadi M, Ghavami S. The R620W (rs2476601) functional polymorphism of protein tyrosine phosphatase non-receptor type 22 (PTPN22) is not associated with pulmonary tuberculosis in Zahedan, southeast Iran”, 2012, Genet. Mol. Res., 11(2): 1175-1181.

1. Hashemi M, Mazeni-Roudi A, Arbabi F, Fazaeli AA, Taheri M, Kerkhoff C, Ghavami S. RAGE Polymorphisms Associated with Breast Cancer in the Southeast Iran Population, 2012, Nucleosides, Nucleotides and Nucleic Acids, 31(5): 401-410.

1. Ghavami S, Mutawe MM, Schaafsma D, Yeganeh B, Unruh H, Klonisch T, Halayko AJ. Geranylgeranyl Transferase 1 Modulates Autophagy, Apoptosis in Human Airway Smooth Muscle, 2012, Am. J. Physiol. Lung Cell and Mol. Physiol., 302(4):L420-8 (Impact Factor 4.8, 27 citations).
2. Gerthoffer WT, Schaafsma D, Sharma P, Ghavami S, Halayko AJ. Airway smooth muscle motility, survival and proliferation. 2012, Comprehensive Physiology, 2(1): 255-288 (Impact Factor 6.7, 6 citations).
3. Hashemi M, Eskandar-Nasab E, Fazaeli AA, Bahari A, Hashemzehi N, Shafieipour S, Taheri M, Ghavami S.  Association of genetic polymorphisms of glutathione S-transferase genes (GSTT1, GSTM1 and GSTP1) and susceptibility to nonalcoholic fatty liver disease in Zahedan, Southeast. 2012, DNA & Cell Biology, 31 (5): 672-7.

1. Hashemi M, Eskandari Nasab E, Zakeri Z, Atabaki M, Bahari G, Jahantigh M, Taheri M, Ghavami S. Association of pre-miRNA-146a rs2910164 and pre-miRNA-499 rs3746444 polymorphisms and susceptibility to Rheumatoid arthritis in an Iranian population. 2012, Mol. Biol. Rep. (doi: 10.3892/mmr.2012.1176.) (36 citations).

1. Alavian SM, Ande SR, Coombs K, Davoopour, P, Yeganeh B,  Hashemi M, Los M, Ghavami S. Autophagy and Viral Hepatitis, 2011, J. of Viral Hepat., 18(12):821-830 (Impact Factor 3.9, 23 citations).

1. Schaafsma D, McNeill KD, Mutawe MM, Ghavami S, Unruh H, Laviolette M, Chakir J, Halayko, AJ. Statin Inhibits TGFβ-Induced Fibronectin in Non-asthmatic and Asthmatic Airway Fibroblasts, 2011, Respiratory Res. 12:113 (Impact Factor 3.9, 33 citations).

1. Naderi M, Hashemi M., Karami H, Moazeni-Roodi A, Sharifi-Mood B, Kouhpayeh H, Taheri M, Ghavami S. Lack of association between rs1024611 (-2581 A/G) polymorphism in CC-chemokine ligand 2 and susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran. 2011, Prague Med. Rep., 112 (4):272-278.

1. Hashemi M, Yaghmaei M, Azarian A, Moazeni-Roodi-A, Mokhtari M, Naghavi A, Salimi S, Mohammadi M, Taheri M, Ghavami S. Association of L55M and Q192R polymorphisms of Paraoxonase-1 gene with preeclampsia, 2011, Arch. Med. Res., 42 (4): 324-326 (9 citations).

1. Hashemi M, Ghavami S. Hepatocellular recurrence after orthotopic liver transplantation: Is combination of α-fetoprotein and glypican-3 a reliable marker? 2011, Hep Mon 11(3): 155-156.

1. Pirzad J, Jafari M, Ghavami S, Amin Abasi M, Shajiei A, Ghanei M. Sulphur Mustard-Induced Lung Injury: Role of Fas-FasL-Induced Apoptosis in BALF Cells. 2011, Journal of Toxicology (doi:10.1155/2010/373612).

1. Kaykhaei MR, Hashemi M, Narouie B, Shikhzadeh A, Rashi H, Moulaei NA, Ghavami S. High Prevalence of vitamin D deficiency in Zahedan, southeast Iran. 2011, Ann Nutr Metab, 58(1): 37-41 (Impact Factor 2.4, 24 citations).

1. Hashemi M, Sharifi-Mood B, Nezamdoost N, Moazeni-Roodi A, Naderi M, Kouhpayeh HR, Taheri M, Ghavami S. Functional Polymorphism of Interferon- γ (IFN-γ) Gene +874T/A Polymorphism is Associated with Pulmonary Tuberculosis in Zahedan, Southeast Iran. 2011, Prague Med. Rep. 112 (1): 38-43.

1. Cunnington RH, Wang B, Ghavami S, Bathe KL, Rattan SG, Dixon IM. Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility. 2011, Am J Physiol- Cell Physiol , 300(1):C176-186 (Impact Factor 4.3, 33 citations).

1. Ghavami S, Mutawe MM, Sharma P, Yeganeh B, McNeill KD, Kashani H.H, Schaafsma D, Klonisch T, Unruh H, Los M, Halayko AJ. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. 2011, PLOS ONE, 6(1):e16523 (Impact Factor 2.9, 57 citations).

1. Schaafsma D, Duek G, Ghavami S, Kroeker A, Hauff K, Xu FY, McNeill KD, Unruh H, Hatch G, Halayko AJ. The Mevalonate Cascade as a Target to Suppress Extracellular Matrix Synthesis by Human Airway Smooth Muscle. 2011, Am J Respir Cell Mol, 44(3):394-403 (Impact Factor 4.3, 36 citations).

1. Mokhtari M, Hashemi M, Yaghmaei M, Naderi M, Shikhzadeh A, Ghavami S. Evaluation of the serum leptin in normal pregnancy and gestational diabetes mellitus in Zahedan, southeast Iran. 2011, Arch Gynecol Obstet: 284(3):539-42 (9 citations).

1. Sharma P, Ghavami S, Stelmack GL, McNeill KD, Mutawe MM, Klonsich T, Unruh H, Halayko AJ. Caveolin-1 interaction with β-dystroglycan is important in Gαq-PLCβ1 mediated calcium release in smooth muscle. 2010, J Cell Sci, 123(Pt 18):3061-70 (Impact Factor 5.3, 30 citations).

1. Ghavami S, Halayko AJ, de Serres FJ. Alpha 1 antitrypsin deficiency: A disease with numerous adverse effect in Human. 2010, Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry (AIAAA), 9(4):276-278. 

1. Naderi M, Hashemi M, Mehdizadeh A, Mehrabifar H, Kouhpayeh HR, Ansari H, Moazeni-Roudi A, Bahari G, Ghavami S. Serum adenosine deaminase and total antioxidant capacity of plasma in pulmonary tuberculosis and non-tuberculosis pulmonary disease. 2010, Turk J of Med Sci, 40(5): 701-705 (9 citations).

1. Hashemi M, Moazeni-Roodi K, Fazaeli A, Sandoughi M, Taheri M, Bardestani G, Kordi-Tamandani DM, Ghavami S. Determination of L55M and -107C/T polymorphisms of Paraoxonasae-1 in Rheumatoid Arthritis using tetra ARMS-PCR. 2010, Genet Mol Res, 9(3):1735-1741.

1. Ghavami S,  Mutawe MM, Hauff K, Stelmack GL, Sharma, P, McNeill KD, Hynes T, Kung SK, Unruh H, Klonisch T, Hatch MH, Los M, Halayko AJ. Statin-triggered Cell Death in Primary Human Lung Mesenchymal Cells Involves p53-PUMA and Release of Smac and Omi but not Cytochrome c. 2010, Biochim Biophys Acta-Mol. Cell Res, 1803(4): 452-467 (Impact Factor 5.3, 46 citations).

1. Hashemi M, Moazeni-Roodi K, Fazaeli A, Sandoughi M, Bardestani G, Kordi-Tamandani DM, Ghavami S. Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in Southeast Iran. 2010, Genet Mol Res, 9(1): 333-339 (Impact Factor 0.8,70 citations).

1. Ghavami S, Eshraghi M, Rao Ande S, Chazin WJ, Klonisch T, Halayko AJ, Kerkhoff C, Los M. S100A8/A9 simultaneously induces autophagy and apoptosis via cross-talk of mitochondria and lysosomes mediated by ROS and it involves BNIP3. 2010, Cell Res., 20(3): 314-331 (Impact Factor 16.3, 96 citations).

1. Hashemi M, Mehrabifar H, Daliri M, Ghavami S. Adenosine deaminase activity, trypsin inhibitory capacity and total antioxidant capacity in patients with psoriasis. 2010, J. Eur. Acad. Dermatol. Venereol, 24(3):329-34.

1. Kerkhoff C, Ghavami S. Innate immunity molecules S100A8/A9 involved in stress response and cancer biology. 2009, Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry (AIAAA), 8(4):279-281.

1. Ghazanfari T, Sharifnia Z, Yaraee R, Pourfarzam S, Kariminia A, Mahlojirad M, Faghihzadeh S, Jalali-Nodoushan MR, Ardestani SK, Soroush MR, Amiri S, Hassan ZM, Ghavami S, Ghanei M. Serum soluble Fas ligand and nitric oxide in long-term pulmonary complications induced by sulfur mustard: Sardasht-Iran Cohort Study. 2009, Int. Immunopharmacol., 9(13-14): 1489-1493 (16 citations).

1. Ghavami S, Chitayat S, Hashemi M, Eshraghi M, Chazin WJ, Halayko AJ, Kerkhoff C. S100A8/A9: a Janus-faced molecule in cancer therapy and tumorigenesis. 2009, Eur. J. Pharmacol., 625(1-3):73-83 (Impact Factor 2.6, 62 citations).

1. Ghavami S, Eshraghi M, Kadkhoda K, Mutawe MM, Maddika S, Bay GH, Wesselborg S, Halayko AJ, Klonisch T, Los M. Role of BNIP3 in Tumor Necrosis Factor Alpha-induced-cell death: TNF up-regulates BNIP3 expression. 2009, Biochim Biophys Acta-Mol. Cell Res., 1793(3):546-60 (Impact Factor 5.3, 33 citations).

1. Halayko AJ, Ghavami S. S100A8/A9: A mediator of severe asthma pathogenesis and morbidity? 2009, Can J Pharm. Physiol. 87(10):743-55 (Impact Factor 1.9, 50 citations).

1. Mokhtari M, Hashemi M, Yaghmaei M, Molashahi F, Shikhzadeh A, Niazi A, Ghavami S. Serum adenosine deaminase activity in gestational diabetes mellitus and normal pregnancy.  2009, Arch. Gynecol. Obstet. 281(4): 623-626 (13 citations).

1. Yaghmaei M, Hashemi M, Shikhzadeh A, Mokhtari M, Niazi A, Ghavami S. Serum trypsin inhibitory capacity in normal pregnancy and gestational diabetes mellitus . 2009, Diabetes Res Clin. Pract., 84(3):201-204 (14).

1. Ghavami S, Hashemi M, Rao Ande S, Yeganeh B, Xiao W, Eshraghi M, Bus CJ, Kadkhoda K, Wiechec E, Halayko AJ, Los M. Apoptosis and Cancer: Mutations within caspase genes. 2009, J. Med Genetics, 46(8): 497-510 (Impact Factor 5.7, 350 citations).

1. Hashemi M, Bahari A, Bahari G, Ghavami S.  Coenzyme Q10 may be effective in the treatment of non alcoholic fatty liver disease (NAFLD). 2008, Irn. J. Med. Hypotheses Ideas, 2:9-10.

1. Hashemi M, Daliri M, Mehrabifar H, Naderi M, Niazi A, Ghavami S. Lipid profile in patients with psoriasis in Zahedan, southeast Iran. 2009, J. Eur. Acad. Dermatol. Venereol., 23(4) 461-2.

1. Hashemi M, Mehrabifar H, Homayooni F, Montazerifar F, Ghavami S. Serum trypsin inhibitory capacity (sTIC) in hemodialysis patients. 2009, Saudi J Kidney Dis Transpl.  20(4): 604-607.

1. Ghavami S, Rashedi I, Dattilio B, Eshraghi M, Chazin WJ, Hashemi M, Wesselborg S, Kerkhoff C, Los M. S100A8/A9 induces growing in various tumor cells via RAGE ligation and MAP kinase phosphorylation. 2008, J Leukoc Biol. Jun;83(6):1484-92 (Impact Factor 4.3, 181 citations).

1. Ghavami S, Kerkhoff C, Chazin WJ, Klonisch T, Xiao W, Kadkhoda k, Eshraghi M, Zuse A, Los M. Cell S100A8/9 Induces Cell Death via a Novel, RAGE-independent Pathway that Involves Selective Release of Smac/DIABLO and Omi/HtrA2, 2008, Biochim Biophys Acta-Mol. Cell Res., 1783: 297-311 (Impact Factor 5.3, 80 citations).

1. Ghavami S, Asoodeh A, Klonisch T, Halayko AJ, Kadkhoda K, Kroczak TJ, Booy E, Naderi-Manesh H, Los M. Brevinin-2R semi-selectively kills cancer cell by a distinct mechanism that involves the mitochondrial death pathway. 2008, J. Cell. Mol. Med. 12(3): 1005-1022 (Impact Factor 4.3, 94 citations).

1. Rashedi I, Panigrahi S, Ezzati P, Ghavami S, Los M. Autoimmunity and Apoptosis-therapeutic application. 2007, Curr Med Chem. 14(29):3139-51.

1. Eshghi P, Alavi S, Ghavami S, Rashidi A. Growth Impairment in beta-Thalassemia Major: The Role of Trace Element Deficiency and Other Potential Factors. 2007, J Pediatr Hematol Oncol. 29(1):5-8 (18) (16 citations).

1. Ghavami S, Hashemi M, de Serres FJ, Naghibzadeh Bajestani S, Mehrabifar H, Leonardi A. Trypsin Inhibitory Capacity in Vernal Keratoconjunctivitis. 2007, Invest Ophthalmol Vis Sci (IOVS), 46 (1): 264-269 (Impact Factor 3.9, 15 citations).

1. Hahsemi M, Naderi M, Rashidi H, Ghavami S. Impaired activity of serum alpha-1 activity in diabetis mellitus. 2007, Diabetes Res. Clin. Pract., 75(2): 246-248.

1. Hashemi M, Ghavami S, Eshraghi M, Booy EP, Los, M. Cytotoxic effects of intra-and extracellular zinc chelation on human breast cancer cells. 2007, Eur. J. Pharmacol. 2007, 557(1): 9-19.

1. Taheri M, Rahimi M, Naderi M, Ghavami S, Mokhtari M, Rashidi H, Hashemi M. Effects of a subdermal levonorgestrel contraceptive implant (Norplant) on serum cholesterol, triglycerides, ALT and AST in Iranian women. 2006, Contraception, 2006, 73(1): 56-58.

1. Ghavami S, Hashemi M, Kadkhoda K, Alavian SM, Bay GH and Los M. Apoptosis in Liver Diseases – Detection and Therapeutic Applications. 2005, Med. Sci. Monitor, 2005, 11(11): RA337-345 (Impact Factor 1.7, 85 citations).

1. Hashemi M, Karami-Tehrani F, Ghavami S, Maddika S, Los M. Adenosine and deoxyadenosine induces apoptosis in estrogen receptor positive and negative human breast cancer cells via the intrinsic pathway, 2005, Cell Proliferat, 38(5): 269-285 (Impact Factor 3.1, 35 citations).

1. Pour-Jafari H, Ghavami S, Maddika S. Mitochondrial physiology and toxicity (mitotoxicity): importance for the immune system, programmed cell death and cancer. 2005, Curr. Med. Chem (AIAA), 4(4): 439-448.

1. Kerkhoff C, Ghavami S. Induction of apoptotic cell death in tumor cells by S100A8/A9 released from inflammatory cells upon cellular activation. Curr. Med. Chem (AIAA), 2005: 4(4): 383-391

1. Hashemi M, Alavian SM, Ghavami S, De Serres FJ, Doroudi T, Salehi Masoud, Mehrabi Far H, Milani B, Saeidi Shahri J. High prevalence of alpha 1 antitrypsin deficient phenotypes in HBV infected individuals in Iran. 2005, Hepatol. Res., 33 (4): 292-297 (19 citations).

1. Maddika S, Booy EP, Johar D, Ghavami S, Los M. Cancer-specicifc toxicity of apoptotic is independent of death receptor s the los of mitochondrial membrane potential  and the release of mitochondria cell death mediators. 2005, J. Cell Sci, 118(Pt 19):4485-93 (Impact Factor 5.3, 80 citations).

1. Ghavami S, Hashemi M, Shahriari HA, Naghibzadeh Bajestani S, de Serres FJ, Miri Moghadam E, Kazemi M., Alavian SM, Taheri M, Blanco I, Bustillo, EP, Alpha 1 antitrypsin phen otypes and HLA-typing in Uveitis patients in southeast Iran. 2005, Clin Biochem., 38(5): 425-432 (Impact Factor 2.4,15 citations).

1. Hashemi M, Karami F., Ghavami S, Sirati M. Adenosine deaminase activities in the estrogen receptor positive and negative human breast cancer cell lines. 2005, Medical Journal of Islamic Republic of Iran. , 19 (1): 53-56.

1. Barczyk K, Kreuter M, Pryjma J, Booy EP, Maddika S, Ghavami S, Roth J, Berdel WE, and M Los  High serum cytochrome c level is a negative prognostic marker in cancer patients. 2005, Int. J. Canc., 116(2): 425-432 (Impact Factor 6.3, 75 citations).

1. Ghavami S, Hashemi M, Karami F, Farzami B ,Taghikhani M. The effect of extracellular zinc sequestration on the cell growth using colon cancer cell lines. 2005, Iranian Biomedical Journal, 9(4): 169-175.

1. Ghavami S, Kerkhoff C, Los M, Hashemi M. Sorg C, Karami F. Mechanism of apoptosis induced by calprotectin in colon cancer cell lines: The role of ROS and the effect of metal ions. 2004, J Leuk. Biol., 76(1): 169-165 (Impact Factor 4.3, 120 citations).

1. Ghavami S, Karami F, Hashemi M, Nikoogoftar Zarif M. Possible involvement of a specific cell surface receptor for calprotectin-induced apoptosis in colon adenocarcinoma and carcinoma cell line (sw742, ht29/219). 2004, Journal of Science of Islamic republic of Iran, 15(1): 3-11 (10 citations).

1. Hashemi M, Karami F, Ghavami S. Cytotoxic effect of cladribine on MCF-7 human breast cancer cell line. 2004, Iranian Biomedical Journal, 8(1): 7-12.

Selected Persian Full Length Manuscripts (2004-2009):

1. Hashemi M, Ghavami S. Methods for detection of apoptosis. Journal of Rafsanjan University of Medical Sciences 2008;7(1):71-78.

2. Ghavami S, Hashemi M, Alavian SM. Alpha 1 antitrypsin: A protein with different function. Review. . Tabib-e- Shargh, 2004; 5(1):77-87.

3. Hashemi M, Ghavami S. Calprotectin; a protein with different function. Tabib-e- Shargh 2005; 4: 307-313.

4. Hashemi M, Ghavami S. Effects of estradiol, progesterone and testosterone on proliferation of human breast cancer cell lines. Tabib-e-Sharg 2005;7:21-29.

Book chapters:

1. Alizadeh J, Shojaei S, Sepanjnia A, Hashemi M, Eftekharpour E, Ghavami S.  Simultaneous Detection of Autophagy and Epithelial to Mesenchymal Transition in the Non-Small Cell Lung Cancer Cells. in: “Spriger/Nature Methods in Molecular Biology ” Series, Book Tittle: Autophagy in Differntiation and Tissue Maintenance: Methods and Protocols, edited by Kursad Turksun; Nature Springer Press (2018), Methods in Molecular Biology (SPRO-D-17-00077).

2. Moosavi MA, Rahmati M, Ashtari N, Alizadeh J, Bathaie SZ, Ghavami S.  Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development. in: “Contemporary Clinical Neuroscience” Series, Book Tittle: Development of the Cerebellum from Molecular Aspects to Diseases, edited by Hassan Marzban; Nature Springer Press (2017), (ISBN- 978-3-319-59748-5).

3. Yeganeh B, Jager R, Gorman A, Samali A, Ghavami S.  Autophagy and Unfolded Protein Response. in: “Autophagy” Book Series edited by R. Hyat; Elsevier Press, (2015), (ISBN-13: 978-0124058774).

4. Shojaei S, Kiumarsi A, Rezaei Moghaddam A, Alizadeh J, Ghavami S. Perillyl Alcohol (Monoterpen Alcohol, Limonene: Application of Perillyl Alcohol and Limonene in Cancer Therapy. in: “ENZ 36 Natural Products and Cancer Signaling Targets: Isoprenoids, polyphenols and favonoids” Book Series edited by Fuyu Tamanoni, Zahra Bathaei; Elsevier Press, (2014), (ISBN:978-0-12-802215-3).

5. Savelyeva A, Ghavami S, Asoodeh A, and M. Los. Brevinin-2R and Related Molecules as Novel Anticancer Agents in: “Anticancer Genes” edited by Stefan Grimm; Springer Academic Press, (2014), ISSN 0065-2598, ISBN 978-1-4471-6457-9.

6. Kerkhoff C, Ghavami S. S100A8 (S100 Calcium Binding Protein 8) gene in Cancer. (2011), 15 (9):735-745. In “Atlas of Genetics and Cytogenetics in Oncology and Hematology”. Editor: Jean-Loup Huret, Genetics DIM, University Hospital, F-86021 Poitiers, France, ATLAS - ISSN 1768-326.

7. Kerkhoff C, Ghavami S. S100A9 (S100 Calcium Binding Protein 9) gene in Cancer. (2011), 15 (9):746-757. In “Atlas of Genetics and Cytogenetics in Oncology and Hematology”. Editor: Jean-Loup Huret, Genetics DIM, University Hospital, F-86021 Poitiers, France, ATLAS - ISSN 1768-326.

8. Ghavami S, Ande SR, Hashemi M, Chitayat S, Chazin WJ, Halayko AJ, Karami-Tehrani F, Kerkhoff, C and M Los “ (2009), pp219-245,  Apoptin, Brevinin-2R, and S100A8/A9; three anticancer proteins and peptides with different mechanisms of action”. In "Proteins Killing Tumour Cells", Series: Cell Death and Disease Eds. Backendorf, Borst, Noteborn, Tavassoli, Research-Signpost (ISBN: 978-81-7895-405-9).

9. Hansen LL, Wiechec E, Wojdacz TK, Ghavami S, Panigrahi S, Schulze-Osthoff K. and M Los, (2008), Essentials in DNA Analysis Techniques. in: "Molecular Biology in Cancer: Toward New Therapies."; edited by: J. García-Foncillas, Prous Science Press, Spain.

10. Ghavami S, Barczyk K, Maddika S, Vogl T, Steinmüller L, Pour- Jafari H, Evans JA, and M. Los. Monitoring of programmed cell death in vivo and in vitro, (new and old methods of cancer therapy assessment). in: “Apoptotic pathways as target for novel therapies in cancer and other diseases.” edited by M. Los & S.B Gibson; Springer Academic Press, (2005), pp323-42, ISBN: 0-387-23384-9.

Invited Speaker and Workshop Organazing:

1. Manitoba Neuroscience Network Seminar Series. “Mevalonate Cascade Inhibition and Glioblastoma Multiform: Role of Autophagy Modulation in Sensitizing the glioblastoma cells to Temozolomide”  January 26^th, 2018, Winnipeg, Canada.

1. Apoptosis Research Centre Seminar Series, “Mevalonate Pathway in Cancer: Possible New Application of and Old Drug, Statins” December 11^th, 2017, Apoptosis Research Centre, National University of Ireland, Ireland.

1. University of Manitoba Edge of Science Seminar Series. “Mevalonate Pathway in Cancer: Possible New Application of and Old Drug, Statins” December 4^th, 2017, University of Manitoba, Winnipeg, Canada.

1. The 7^th  International Tehran Hepatitis Conference. “Liver Fibrosis in HBV or HCV Infected Patients: Role of Autophagy and Unfolded Protein Response”  September 6-8 , 2017, Tehran, Iran.

1. The 7^th  International Tehran Hepatitis Conference. “Apoptosis, Autophagy and Unfolded Protein Response in HBV and HCV”  September  9 , 2017, Shiraz, Iran.

1. The 2^nd National Festival & International Congress on Stem Cell & Regenerative Medicine. “Autophagy Inhibition Directs the Epithelial to Mesenchymal Transition in Non-mall Lung Cancer Cells”  July 13-15 , 2017, Tehran Iran.

1. The 2^nd National Festival & International Congress on Stem Cell & Regenerative Medicine. “Autophagy and the Unfolded Protein Response Promote Pro-fibrotic Effects of TGFbeta1 in Human Lung Fibroblasts”  July 13-15 , 2017, Tehran Iran.

1. Organizer of 2^nd Annual Research Day in Department of Human Anatomy and Cell Science, University of Manitoba, Manitoba, Canada.  May 31^st , 2017.

1. Department of Mechanical Engineering, University of Victoria, Victoria, Canada.” Autophagy and Cellular Phenotype”,   March 23^rd , 2017.

1. International Symposium in Endoplasmic Reticulum Stress.” Role Endoplasmic Reticulum Stress and Autophagy in Regulation of Fibrosis in Asthma and Idiopathic Pulmonary Fibrosis”,   May 18-19^th, 2016, National University of Ireland, Galway, Ireland.

1. Organizer of International Biology of Breathing Symposium on Disease Origins and Cell Fate in the Lung. March 21^st,  22^nd, 2016, Winnipeg, Canada.

1. Organizer of Edge of Science Talk Series, Invited Speaker Dr. Daniel Klionsky, March 21^st , 2016,  Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada

1. International Biology of Breathing Symposium on Disease Origins and Cell Fate in the Lung. “CHOP-ping Possibilities for Autophagy and Unfolded Protein Response in Pulmonary Hypertension” March 22^nd, 2016, Winnipeg, Canada.

1. Department of Pharmacology and Therapeutics Invited series talk. “Mevalonate Cascade Inhibition in Combination of Temozolomide: As New Approach to Target Glioblastoma Multiforme”, February  12^th , 2016, Winnipeg, Canada.

1. Manitoba Neuroscience Network Invited series talk. “Targeting Mevalonate Cascade: A New Advancement in Glioblastoma Therapeutic Approach?”, November 27^th , 2015, Winnipeg, Canada.

1. Department of Immunology Invited series talk. “Autophagy and Fibrotic Disease in Lung and Heart”, September 24^th , 2015, Winnipeg, Canada.

1. 2^nd  Cardiovascular Forum for Promoting Centers of Excellence and Young Investigators. “Autophagy modulates TGF-beta-1 profibrotic effects”, September 4^th - 6^th, 2014, Winnipeg, Canada.

1. Edge of Science and Medicine Seminar Series. “Autophagy and UPR Regulates TGF-beta1-induced Extracellular Matrix Biosynthesis”, January 6^th, 2014, University of Manitoba, Winnipeg, Canada.

1. Pulmonary, Critical Health Care & Sleeping Division, “S100A8/A9 –RAGE Axis in Asthma”, October, 10^th, 2013, University of California, Davis, USA.

1. Pulmonary, Critical Health Care & Sleeping Devision, “Modulation of H1N1 Replication by Apoptosis/Autophagy/Endoplasmic Reticulum Stress.”, September, 18^th, 2013, University of California, Davis, USA.

1. Department of Human Anatomy and Cell Science, Faculty of Medicine, “Lung Histology.” August 20^th, 2013, University of Manitoba, Winnipeg, Canada (Invited talk as a candidate for Assistant Professor Position). 

1. Department of Human Anatomy and Cell Science, Faculty of Medicine, “Extracellular Function of S100A8/A9 in Different Models.” August 19^th, 2013, University of Manitoba, Winnipeg, Canada (Invited talk as a candidate for Assistant Professor Position).  

1.  Health Policy Research Centre, “Importance of Apoptosis and ER Stress Pathways in Viral Hepatitis (HCV, HBV) and Their Therapeutic Applications”, May 20^th, 2013, Shiraz Medical University, Shiraz, Iran.

1. 5^th International Tehran Hepatitis Congress, “Importance of Apoptosis and ER Stress Pathways in Viral Hepatitis (HCV, HBV) and Autoimmune Hepatitis (AIH) and Their Therapeutic Applications”, May 16^th, 2013, Tehran, Iran.

1. Department of Physiology, Faculty of Medicine, “Chronic Obstroctive Pulmonary Disease: Role of Portease and Antiprotease Imbalance” Feb. 14^th, 2013, University of Manitoba, MB, Canada (invited talk as a candidate for an Assistant Professor Position).

1. Department of Physiology, Faculty of Medicine, “Autophagy and Endoplasmic Reticulum Stress Regulate TGF-b₁mediated Extracellular Matrix Biosynthesis in the Lung” Feb. 13^th, 2013, University of Manitoba, MB, Canada (invited talk as a candidate for an Assistant Professor Position).

1. Department of Oral Biology, Faculty of Dentistry, “Extracellular Functions of S100A8/A9 (Calprotectin) in Different Models” Jan. 22^nd, 2013, University of Manitoba, MB, Canada (invited talk as a candidate for an Assistant Professor Position).

1. Center for Comparative Respiratory Biology and Medicine,  “Cell Death Events via Mevalonate Cascade Inhibition in Airway Mesenchymal and Epithelial Cells” Dec. 13^th , 2012, University of Davis, California, USA.

1. Center for Comparative Respiratory Biology and Medicine “Autophagy and Fibrosis:Current Knowledge and Future Directions” Dec. 14^th , 2012, University of Davis, California, USA.

1. Department of Biochemistry, Apoptosis Research Centre “Cell Death Mechansim of Mevalonate Cascade Inhibition in Human Airway Mesenchymal Cells” Nov., 2012, National University of Ireland, Ireland.

1. St. Boniface Research Hospital “Autophagy and ER-stress Are Involved in Cellular Fate and Cell Pheno-conversion” Oct., 2012, University of Manitoba, Winnipeg, Canada.

1. Ferdowsi University, Mashhad, Iran. “Autophagy Application as new therapeutic approach in viral infections ”. May, 1^st. 2012, Mashhad, Iran.

1. 11^th International Congress of Immunology and Allergy. “Targeting cell Death pathway as new therapeutic approach in viral infections”. 25 April. 2012, Tehran, Iran.

1. 11^th International Congress of Immunology and Allergy. “Mevalonate Cascade Cell Death and Asthma : New Therapeutic Approach for Asthma Therapy” 27 April. 2012, Tehran, Iran.

1. 11^th International Congress of Immunology and Allergy. “New approaches in Asthma Therapy: Targeting S100A8/A9-RAGE Axis.” 29 April. 2012, Tehran, Iran.

1. 11^th International Congress of Immunology and Allergy. “Targeting Autophagy for Modulation TGF-beta Induced Fibrosis in Asthma ”. 27 April. 2012, Tehran, Iran.

1. 4^th International Tehran Hepatitis Congress. “Hepatocellular Carcinoma and Cell Death: Possible Therapeutic Applications”. 23-26 Nov. 2011, Tehran Shiraz, Iran.

1.  4^th International Tehran Hepatitis Congress. “Autophagy and Liver Diseases: Focusing on HBV and HCV”. 23-26 Nov. 2011, Tehran Shiraz, Iran.

1. Organizing and Lecturing First International Workshop on “Apoptosis and Autophagy.” 23 Nov. 2011, Tehran, Iran.

1. Biology of Breathing Theme Seminar Series, “Geranylgeranyl transferase I Induced Apoptosis and Autophagy in Airway Mesenchymal Cells”, Sept. 2011, University of Manitoba, Winnipeg, Canada.

1. Department of Biochemsitry, National University of Ireland, “Autophagy Regulates Fibrosis in Airway Mesenchymal and Atrial Fibroblast Cells”. August 2011, Galway, Ireland.

1. Biology of Breathing Theme Seminar Series, “Mevaloante Cascade Inhibition Induces Apoptosis, Autophagy, and ER-Stress in Airway Mesenchymal Cells”, May. 2011, University of Manitoba, Winnipeg, Canada.

1. Manitoba Institute of Child Health, Pediatric Research Round, “Autophagy Regulates Fibrosis in Lung and Heart”, Jan, 2011, University of Manitoba, Winnipeg, Canada.

1. Section of Respiratory Medicine, Research in Progress Seminar Series, “Autophagy and Lung Diseases” Feb 2011, University of Manitoba, Winnipeg, Canada.

1. 3^rd International Tehran Hepatitis Congress. “Autophagy in Viral Hepatitis: A new Therapeutic    Approach”. 6-9 Oct 2010, Tehran, Shiraz, Iran.

1. 3^rd International Tehran Hepatitis Congress. “Alpha 1 Antitrypsin Deficiency: Molecular Mechanism”. 6-9 Oct 2010, Tehran, Shiraz, Iran.

1. Manitoba Institute of Child Health, Pediatric Research Round, “The Mechanisms of Simvastatin-induced Cell Death on Airway Mesenchymal Cells”, Sept., 2010, University of Manitoba, Winnipeg, Canada.

1. Section of Respiratory Medicine, Research in Progress Seminar Series, “Beneficial Effect of Simvastatin on the Lung: A new Chemical Thermoplastic Tool?” Feb. 2011, University of Manitoba, Winnipeg, Canada.

1. National Training Program in Asthma and Allergy Research Talk Series, “Possible Role of S100A8/A9 in Airway Remodelling in Asthma”, April 2009, University of Manitoba, Winnipeg, Canada.

1. Biology of Breathing Theme Seminar Series, “Apoptosis, Autophagy Cross Talk: Focusing on S100A8/A9 Cell Death Mechansims”, August 2007. University of Manitoba, Winnipeg, Canada.

1. Cancercare Manitoba, Retreat, “Cell Death Mechanisms of Brevinin-2R on Cancer Cells”, September 2005, Gimli, Manitoba, Canada.

1. Cancercare Manitoba Invited Lecturer Series, “Cell Death Mechansims of S100A8/A9 on Colon Cancer Cell lines”, June 2004, University of Manitoba, Winnipeg, Canada.

Selected Abstracts in National or International Congress Published in Peer-Review Journal:

1. Elena Tarricone, Andrea Leonardi, Antonino Di Stefano, Saeid Ghavami, Paola Brun. Possible Autophagy induction in Vernal Keratoconjunctivitis via Tumor Necrosis Factor Alpha Stimulation. Poster Presentation at 2017 Italian Society of Histology and Anatomy, Rome, Italy, September 20-22, 2017, Italian Journal of Anatomy and Embryology, Vol. 122, n. 1 (Supplement): 211, 2017.

2. Ojo O. Oluwaseun, Saeid Ghavami, Sujata Basu, Aruni Jha, Min. H. Ryu, Jacquie Schwartz, Diana C. Doeing, John McConville, Thomas Vogl, Johannes Roth, Andrew J. Halayko. S100A8/A9 Mediates Pathophysiologic Hallmarks of Chronic Allergic Asthma.  Poster Presentation at 2015 American Thoracic Society International Conference, Denver, Colorado, USA. May 15-20. Am. J. Resp. Crit. Care Med, 2015, 189:A4119

3. Saeid Ghavami, Behzad Yeganeh, Amir A. Zeki, Nicholas J. Kenyon, Sean Ott, Afshin Samali, John Peterson, Ian MC Dixon, Darryl A Knight, Andrew J Halayko. Autophagy and the Unfolded Protein Response are Necessary for TGF-b1-Induced Profibortic Effects in Normal and Idiopathic Pulmonary Fibrosis Fibroblasts. Poster Presentation at 2014 American Thoracic Society International Conference, San Diego, CA, USA. May 17-22. Am. J. Resp. Crit. Care Med, 2014,188:A4946. 

4. Amir A. Zeki, Sean Ott, Kamaldeep Sandhu, Saeid Ghavami, Nicholas Kenyon. The Complex Roles Of Endoplasmic Reticulum Stress, Autophagy, And Apoptosis In Modulating Eotaxin-3 Production And Secretion From Human Airway Epithelial Cells. Poster Presentation at 2014 American Thoracic Society International Conference, San Diego, CA, USA. May 17-22. Am. J. Resp. Crit. Care Med, 2014.

5. Matthew Zeglinski, Jared Davis, Saeid Ghavami, Krista Bathe, Sunil Rattan, Ian Dixon. Expression of SKI induces Apoptosis and Represses Autophagy in Cardiac Myofibroblasts. Poster Presentation at Experimental Biology 2014, SanDiego, CA, USA. April 26-30 2014. FASEB J. 28 (1):868.8.

6. Behzad Yeganeh, Saeid Ghavami, William Summers, Thomas Klonisch, John A Wilkins, Marek J. Los, Andrew J. Halayko, Kevin M. Coombs. Autophagy-dependent mechanism of apoptosis activation in influenza A virus infection. Oral Presentation at 2013 American Society for Virology Conference, Pennsylvania, USA. July 20-24.

7. Saeid Ghavami, Darryl L Knight, Andrew J Halayko. Autophagy is Necessary for TGF-β1-Induced Extracellular Matrix Expression in Idiopathic Pulmonary Fibrosis Lung Fibroblasts. Poster Discussion Presentation at 2013 American Thoracic Society International Conference, Philadelphia, USA. May 17-22. Am. J. Resp. Crit. Care Med, 2013, 187: A5156.

8. Hessam H. Kashani, Saeid Ghavami, Darryl L Knight, Soma Tripathi, Karen A. Detillieux, William T. Gerthoffer,Helmut Unruh, Andrew J Halayko. Intracellular HMGB1 Modulates Extracellular Matrix Synthesis by Human Airway Smooth Muscle Cells. Oral Presentation at 2013 American Thoracic Society International Conference, Philadelphia, USA. May 17-22. Am. J. Resp. Crit. Care Med, 2013, 187: A5264.

9. Sean Ojo Olowasun, Saeid Ghavami, Helmut Unruh, Andrew J Halayko. High Mobility Group Box 1 (HMGB1) Mediates Pro-Asthma Functional Responses In Human Bronchial Epithelial Cells. Poster Discussion Presentation at 2013 American Thoracic Society International Conference, Philadelphia, USA. May 17-22. Am. J. Resp. Crit. Care Med, 2013, 187: A185.

10. Sean Ojo Olowasun, Saeid Ghavami, Gerald Stelmack, Helmut Unruh, Andrew J Halayko. High Mobility Box Group 1 (HMGB1) Attenuates Proliferation And Promotes ER Stress- Associated Autophagy In Human Bronchial Epithelial Cells Poster Discussion Presentation at 2013 American Thoracic Society International Conference, Philadelphia, USA. May 17-22. Am. J. Resp. Crit. Care Med, 2013, 187; 187:A4763.

11. Kiranjit K Sran, Yun Li, Saeid Ghavami, Melanie Ngo, Lorrie Kirshenbaum, Darren Freed. Differntial effect of lipophilic versus hydrophilic statins on survival of human atrial fibroblasts in vitro. Poster presentation at 2012 Canadian Cardiovascular Congress, October 27-31, Toronto, Ontario, Canada, Canadian Journal of Cardiology, 2012, 28 (5): S239-S240.

12. Saeid Ghavami, Thomas Vogl, Johannes Roth, Claus Kerkhoff, Andrew J Halayko. S100A8 And S100A9 Homo-, And Hetero-Dimers Affect Extracellular Matrix In Human Smooth Muscle With Different Down Stream Signalling. Poster discussion at 2012 American Thoracic Society International Conference, San Francisco, CA, USA. May 18-24, Am. J. Resp. Crit. Care Med, 2012,  185: A5098.

13. Saeid Ghavami, Behzad Yeganeh, Pawan Sharma, Mark M Mutawe, Hessam H Kashani, Andrew J Halayko. Mevalonate Cascade Inhibition Induced Apoptosis, Autophagy, And ER-Stress In Airway Mesenchymal Cells: Regulatory Function Of Autophagy And Bcl2 Pro-Apoptotic Proteins. Oral Presentation at 2012 American Thoracic Society International Conference, San Francisco, CA, USA. May 18-24, Am. J. Resp. Crit. Care Med., 2012,  185: A5098.

14. Behzad Yeganeh, Saeid Ghavami, Kevin Coombs, Andrew J Halayko. Influenza A Virus Replication In A549 Human Epithelial Cells Requires Activation Of Autophagy Pathways. Oral Presentation at 2012 American Thoracic Society International Conference, San Francisco, CA, USA. May 18-24, Am. J. Resp. Crit. Care Med., 2012, 185: A5081.

15. Hessam H Kashani, Saeid Ghavami, Mark M Mutawe, Soma Tripathi, Gerald L Stelmack, Helmut Unruh, Andrew J Halayko. An Autocrine Mediator of TGF-β1 Induced Extracellular Matrix Production by Human Airway Smooth Muscle Cells. Poster discussion at 2012 American Thoracic Society International Conference, San Francisco, CA, USA. May 18-24, Am. J. Resp. Crit. Care Med, 2012, 185: A4144.

16. Amir A Zeki, Saeid Ghavami, Andrew J Halayko, Reen Wul. The Effects of Simvastatin on Human Airway Epithelial Cell Viability and Morphology. Oral Presentation at AMFR Eastern Regional Meeting 2012, 18^th  April 2012, Washington DC, US, J Invest. Med, 2012, 60(4): p283.

17. Saeid Ghavami, Behzad Yeganeh, Anna Serebrin, Mark M Mutawe, Gerald L. Stelmack, Pawan Sharma, Karol D McNeill, Ian MC Dixon, Thomas Klonisch, Mark W Nachtigal, Andrew J Halayko, Autophagy Regulates TGF-b1 Induced Fibrosis in Human Airway Smooth Muscle Cells, Poster Presentation at 2011 American Thoracic Society International Conference, 13-18 May 2011, Denver, Colorado, USA, Am. J. Resp. Crit. Care Med, 2011, 183: A2110.

18. Pawan Sharma, XQ Liu, Saeid Ghaavmi, Karol D MacNeill, Mark M Mutawe, Helmut Unruh, Andrew J Halayko. Modifiers of cAMP Signaling Inhibit TGF-b1 Induced Fibrosis Through PKA Mediated Regulation of the MAP Kinase Pathway. Oral Presentation at 2011 American Thoracic Society International Conference, 13-18 May 2011, Denver, Colorado, Am. J. Respir. Crit. Care Med.,2011, 183: A2110.

19. Saeid Ghavami, Mark M Mutawe, Karol McNeill, Pawan Sharma, Thomas Klonisch, Dedmer Schaafsma, Helmut Unruh, Andrew J Halayko. P53 a Janus Faced Molecule in Simvastatin-Induced Cell Death in Airway Mesenchymal Cells. Poster Presentation at 2010 American Thoracic Society International Conference, 14-19 May 2010, New Orleans, Louisiana, USA, Am. J. Resp. Crit. Care Med.,2010, 181: A2125.

20. Saeid Ghavami, Mark M Muawe, Helmut Unruh, Andrew J Halayko. The Mevalonate Cascade Modulates Endoplasmic Reticulum (ER) Stress during Human Airway Mesenchymal Cell Apoptosis. Poster Presentation at 2010 American Thoracic Society International Conference, 14-15 May 2010, New Orleans, Louisiana, USA, Am. J. Resp. Crit. Care Med., 2010, 181: A2124.

21. Pawan Sharma, Saeid Ghavami, Gerald L. Stelmack, Karol D. McNeill, Mark M. Mutawe, Helmut Unruh, Andrew J. Halayko. The Dystrophin Glycoprotein Complex (DCG Regulates Spatial Organization and Function of Caveolae in Human Airway Smooth Mucle Cells. Poster Presentation at 2010 American Thoracic Society International Conference, 14-15 May 2010, New Orleans, Louisiana, USA, Am. J. Resp. Crit. Care Med.,2010, 181: A5294.

1. Saeid Ghavami, Tyler Hynes, Thomas .Vogl, Sujata Basu Claus Kerkhoff, Johannes Roth, Andrew J Halayko. A Role for S100A8/A9 in Allergic Airway Inflammation? Poster discussion at 2009 American Thoracic Society International Conference, San Diego, CA, USA. May 15-20, Am. J. Resp. Crit. Care Med., 2010, 179: A6326.

2. Saeid Ghavami, Amir A Zeki, Mark M Mutawe, Nicolas J Kenyon, Andrew J Halayko. Simvastatin promotes lung cell apoptosis and autophagy in vivo: a link to beneficial effects on lung physiology? Poster Discussion at 2009 American Thoracic Society International Conference, San Diego, CA, USA. May 15-20, Am. J. Resp. Crit. Care Med.,2010, 179: A5603.

3. Saeid Ghavami, Mark M Mutawe, Thomas Klonsich, Karol D McNeill, H Unruh, Andrew J Halayko. Autophagy is a Negative Regulator of Simvastatin-Induced Cell Death in Airway Mesenchymal Cells. Poster Discussion at 2009 American Thoracic Society International Conference, San Diego, CA, USA. May 15-20, Am. J. Resp. Crit. Care Med., 2009,179: A3891.

4. Saied Ghavami, Mark M Mutawe, Karol D McNeill, Dedmar Schaafsma, H Unruh, Andrew J Halayko. Simvastatin Induces Airway Mesenchymal Cells Apoptosis via a Novel p53-Dependent Pathway that Includes Selective Release of Smac/Diablo and Omi/HtrA2 from Mitochondria. Poster at 2009 American Thoracic Society International Conference, San Diego, CA, USA. May 15-20, Am. J. Resp. Crit. Care Med., 2009, 179: A2070.

5. Pawan Sharma, Gerald L Stelmack, Saeid Ghavami, Thomas Klonisch, Andrew J Halayko. -Dystroglycan Interacts with Caveolin-1: Central Role in Intracellular Calcium Mobilization by Airway Smooth Muscle. Poster at 2009 American Thoracic Society International Conference, San Diego, CA, USA. May 15-20, Am. J. Resp. Crit. Care Med.,2009, 179: A2051.

6. Dedmar Schaafsma, Gordon Dueck, Saeid Ghavami, Andrea Kroeker, Kristin Hauff, FY Xu, Karol D McNeill, Andrew J Halayko. Simvastatin and GGTI-286 Are Potent Suppressors of the Profibrotic Function of Primary Human Airway Smooth Muscle Cells. Oral Talk in 2009 American Thoracic Society International Conference, San Diego, CA, USA. May 15-20, Am. J. Resp. Crit. Care Med., 2009, 179: A5603.

7. Dedmar Schaafsma, Karol D McNeill, Andrea Kroeker, H Unruh, Saeid Ghavami and Andrew J Halayko. Simvastatin Inhibits TGFβ1-induced Collagen I Expression in Primary Human Airway Mesenchymal Cells. Poster presentation in a poster discussion session at the 2008 American Thoracic Society International Conference, Toronto, ON, May 16-21, 2008,  Am. J. Resp. Crit. Care Med., 177: A4056.

8. Saeid Ghavami, Dedmar Schaafsma, Karol D McNeill, Pawan Sharma, H Unruh and Andrew J Halayko.  Mechanisms for Simvastatin Induced Human Airway Smooth Muscle and Airway Fibroblast Cell Death.  Oral presentation in a mini-symposium at the 2008 American Thoracic Society International Conference, Toronto, ON, May 16-21, 2008, Am. J. Resp. Crit. Care Med.,2008, 177: A3540.

Selected Abstracts in National or International Congress:

1. Bahram Mirani, Erik Pegan, Saeid Ghavami, Mohsen Akbari. A 3D Bioprinted Hydrogel Mesh Loaded with All-Trans Retinoic Acid for Treatment of Glioblastoma. Oral Presentation, Canadian Biomaterials Society Meeting, Victoria, Canada, May 16-19^th, 2017.

2. Javad Alizadeh, James Thliveris, Thomas Klonisch, Saeid Ghavami. Autophagy Inhibition Directs the Epithelial to Mesenchymal Transition in Non-Small Lung Cancer Cells. Poster Presentation, Canadian Cancer Research Society Meeting, Vancouver, Canada, November 5-7^th, 2017.

3. Sabine Hombach-Klonisch, Forouh Kalantari, Zahra Sepheri, Don Miller, Afshin Samali, Saeid Ghavami, Thomas Klonisch. Brain metastatic Triple Negative Breast Cancer (TNBC) cells display increased activation of the Unfolded Protein Response (UPR). Poster Presentation, Canadian Cancer Research Society Meeting, <Vancouver, Canada, November 5-7^th, 2017.

4. Shahla Shojaei, Javad Alizadeh, James Thliveris, Navid Koleini², E. Kardami, Sabine Hombach-Klonisch, Thomas Klonisch, Saeid Ghavami. Simvastatin sensitizes Glioblastoma Cells to Temozolomide-induced Apoptosis by inhibition of autophagy flux. Poster Presentation, Canadian Cancer Research Society Meeting, <Vancouver, Canada, November 5-7^th, 2017.

5. Javad Alizadeh, Adel Rezaei Moghadam, James Thliveris, Thomas Klonisch, Saeid Ghavami. Autophagy Inhibition Directs the Epithelial to Mesenchymal Transition in Non-Small Lung Cancer Cells. Poster Presentation, University of Manitoba Research Day, June 6-8^th, 2017.

6. Shahla Shojaei, Javad Alizadeh, James Thliveris, Navid Koleini, Sabine Hombach-Klonisch, Thomas Klonisch, Saeid Ghavami. Involvement of Autophagy in Increased Temozolomide-induced Apoptosis by the addition of Simvastatin in Glioblastoma Cells. Poster Presentation, University of Manitoba Research Day, June 6-8^th, 2017.

7. Adel Rezaei Moghadam, Javad Alizadeh, Jared Field, Simone Cristina da Silva Rosa, Saeid Ghavami, Joe Gordon. Role of autophagy in temozolomide-induced apoptosis for Rhabdomyosarcoma cells. Poster Presentation, University of Manitoba Research Day, June 6-8^th, 2017.

8. Javad Alizadeh, Adel Rezaei Moghadam, James Thliveris, Thomas Klonisch, Saeid Ghavami. Autophagy Inhibition Prevents the TGFβ1-Induced Epithelial to Mesenchymal Transition (EMT) in Non-Small Lung Cancer Cells. Poster Presentation, University of Manitoba Research Day, June 7-9^th, 2016.

10. Niloufar Ashtari, Xiadon Xiao, Saeid Ghavami, Hassan Marzban. Autophagy and Cerebellar Purkinje cell Degeneration in the Lysosomal Acid Phosphatase (Acp2) Mutant Mice. Poster Presentation, University of Manitoba Research Day, June 7-9^th, 2016.

1. Xiadon Xiao, Niloufar Ashtari, Karen Balley, Maryam Rahimi Balaei, Saeid Ghavami, Marc Del Bigio, Hassan Marzban. The Study of Sonic Hedgehog Signaling Pathway in Development of Cerebellar Granule Cells. Poster Presentation, University of Manitoba Research Day, June 7-9^th, 2016.

1.  Nagakannan Pandian, Mohamed Ariff Iqbal, James A. Thliveris, Mojgan Rastegar, Saeid Ghavami, Eftekhar Eftekharpour. Lysosomal Dysfunction Underlies the Autophagy-Apoptosis Switch in Neurons:Implication of Thioredoxin System in Neurodegenerative Diseases. Poster Presentation, University of Manitoba Research Day, June 7-9^th, 2016.

1. Adel Rezaei Moghadam, Saeid Ghavami, Joseph Gordon. Temozolomide Induces Dose/Time Dependent Cell Death in Human Rhabdomyosarcoma and Mouse Myoblast Cells. Poster Presentation, University of Manitoba Research Day, June 7-9^th, 2016.

2. Javad Alizadeh, Nima Mirzaei, Aleksandra Glogowska, Sabine Hombach Klonisch, Thomas Klonisch, Saeid Ghavami. Mevalonate Cascade Inhibition Sensitizes Brain Tumor Cells to Temozolomide-induced Cell Death. Poster Presentation, Canadian Cancer Research Conference, Montreal, Canada, November 8-10, 2015.

3. Aleksandra Glogowska, Thatchawan Thanasupawat, Maxwell Burg, Saeid Ghavami, Jerry Krcek, Sabine Hombach-Klonisch, Thomas Klonisch. Relaxin receptor RXFP1 is a novel survival factor and increases chemoresistance in human glioblastoma. Poster Presentation, Canadian Cancer Research Conference, Montreal, Canada, November 8-10, 2015.

    

4. Amir A. Zeki, Sean Ott, Kamaldeep Sandhu, Saeid Ghavami, Nicholas J. Kenyon. The Complex Roles Of Endoplasmic Reticulum Stress And Autophagy In Modulating Eotaxin-3 Production And Secretion From Human Airway Epithelial Cells. UC Davis 6^th Annual Lung Research day, Davis, CA, USA, June 8, 2015.

1. Payam Peymani, Behzad Yeganeh, Saeid Ghavami, Siamak Sabour, Bita Geramizadeh, Mohammad Reza Fattahi, Hossein Keyvani, Negar Azarpira, Maryam Akbari, Kevin M Coombs Kamran B Lankarani. Pilot Clinical Trial With Chloroquine in non-responding HCV Patients. Oral Presentation at 6^th International Tehran Hepatitis Conference/EASL, 2015, Tehran, Iran, May-27-29, 2015.

2. Payam Peymani, Behzad Yeganeh, Saeid Ghavami, Siamak Sabour, Bita Geramizadeh, Mohammad Reza Fattahi, Hossein Keyvani, Negar Azarpira, Maryam Akbari, Kevin M Coombs, Kamran B Lankarani. Effect of Chloroquine Therapyon Anthropometric Parameters, Vit D3, Ferritin and Biochemistry Parameters at HCV Infection Patients: Pilot Trial. Oral Presentation at 6^th International Tehran Hepatitis Conference/EASL, 2015, Tehran, Iran, May-27-29, 2015.

3. Behzad Yeganeh, Peyman Peymani, Adel Rezaei Moghadam, Emilia Wiechec, Seyed Moayed Alavian, Seyed Mohamad Miri, Bita Gramizadeh, Kamaran Bagheri Lankaran², Martin Post, Kevin, M Coombs, Saeid Ghavami.Apoptosis, Autophagy, and Unfolded Protein Response in HCV and HBV Hepatitis. Oral Presentation at 6^th International Tehran Hepatitis Conference/EASL, 2015, Tehran, Iran, May-27-29, 2015.

4. Behzad Yeganeh, Peyman Peymani, Adel Rezaei Moghadam, Emilia Wiechec, Seyed Moayed Alavian, Seyed Mohamad Miri, Bita Gramizadeh, Kamaran Bagheri Lankaran², Martin Post, Kevin, M Coombs, Saeid Ghavami.Autoimmune Hepatitis and Apoptosis, Autophagy, Unfolded Protein Response. Oral Presentation at 6^th International Tehran Hepatitis Conference/EASL, 2015, Tehran, Iran, May-27-29, 2015.

1. Sari S Hannila, Naima Jahan, Saeid Ghavami.  Transforming Growth Factor beta-induced Expression of Chondroitin Sulphate Proteoglycans in Reactive astrocytes: Roles of non-Smad Signaling Pathways and Autophagy. Poster Presentation at Annual Meeting of Society of Neuroscience, 2014, Washington DC, U.S.A, November 16-20, 2014.

2. Hassan Marzban, Karen Bailey, Maryam Rahimi Balaei, Ashraf Mannan, Saeid Ghavami.  Corticogenesis of the cerebellar cortex in lysosomal acid phosphatase (Acp2) mutant mice. Poster Presentation at Annual Meeting of Society of NeuroScience, 2014, Washington DC, U.S.A, November 16-20, 2014.

3. Andrew J Halayko, Aruni Jha, Sujata Basu, Ryan H. Cunnington, Jamila Chakir, Michelle Laviolette, Thomas Klonisch, Ian M.C. Dixon, Helmut Unruh, Saeid Ghavami.  Autophagy Regulates TGF-β1-Induced Extracellular Matrix Synthesis in Human Airway Mesenchymal Cells. Poster Presentation at International Colloquium on Lung and Airway Fibrosis Meeting 2014, Montreal, Quebec, Canada, September 20-24, 2014.

1. Darryl A Knight, Behzad Yeganeh, Amir A. Zeki, Nicholas J. Kenyon, Sean Ott, Andrew Chan, Afshin Samali, John Paterson, Ian MC Dixon, Martin Post, Andrew J Halayko, Saeid Ghavami. Autophagy and Unfolded Protein Response are Necessary for TGF-β1-Induced Profibortic Effects in Idiopathic Pulmonary Fibrosis Fibroblasts. Poster Presentation at International Colloquium on Lung and Airway Fibrosis Meeting 2014, Montreal, Quebec, Canada, September 20-24, 2014.

2. Sean Ott, Kamaldeep Sandhu, Saeid Ghavami, Andrew J. Halayko, Nicholas Kenyon, Amir A. Zeki. Endoplasmic reticulum (er) stress plays a role in experimental allergic asthma: a novel mechanism of how statins inhibit cytokine production. Oral presentation at AMFR Eastern Regional Meeting2014, Sandiego California, January 2014.

3. Shivika Gupta, Saeid Ghavami, Ryan Cunnington, Sunil Rattan, Ian MC Dixon. Autophagy is required for mediated cardiac fibroblast to myofibroblast phenoconversion. Poster discussion at 2012 International Society of Heart Research Conference, Banff, Alberta, Canada. May 28-31.

4. Saeid Ghavami, Behzad Yeganeh, Anna Serebrin, Mark M Mutawe, Gerald Stelmack, Pawan Sharma, Karol D McNeill, Hessam H. Kashani, Thomas Klonisch, Mark W Nachtigal, Ian MC Dixon, Andrew J Halayko, Autophagy is required for TGF-beta1 induced extracellular matrix synthesis in aiway mesenchymal cells. Presentation in Injury and Repair Mechanisms in Chronic Airway Disease, 7-9 April 2011, London, England.

5. Pawan Sharma, XQ Liu, Saeid Ghaavmi, Karol D MacNeill, Mark M Mutawe, Helmut Unruh, Andrew J Halayko. Inhibition of TGF betta 1 fibrosis through a novel cross-tlak between PKA and MAP kinase pathway. Presentation in Injury and Repair Mechanisms in Chronic Airway Disease, 7-9 April 2011, London, England.

6. Saeid Ghavami, Behzad Yeganeh, Anna Serebrin, Mark M Mutawe, Gerald L. Stelmack, Pawan Sharma, Karol D McNeill, Ian MC Dixon, Thomas Klonisch, Mark W Nachtigal, Andrew J Halayko, Autophagy Regulates TGF-b1 Induced ECM synthesis in Human Airway Smooth Muscle Cells, Oral Presentation in 7^th Young Investigator Meeting in Smooth Muscle. 10-12 May 2011, Winnipeg, MB, Canada.

7. Hessam H. Kashani, Saeid Ghavami, Mark M Mutawe, Soma Tripathi, Gerald L. Stelmack, Helmut Unruh, Andrew J Halayko. Essential Role for HMGB1 in TGF-β1 Induced Extracellular Matrix Protein Expression by Human Airway Smooth Muscle Cells, Poster Presentation in 7^th Young Investigator Meeting in Smooth Muscle. 10-12 May 2011, Winnipeg, MB, Canada.

8. Marek Los, Saeid Ghavami, Thomas Klonisch, Andrew J Halayko, Joerg Stetefeld, Frank Schweizer, Klaus Schulze-Osthoff. Hijacking  Cell Survival Pathways and redirecting them into Induction of Cell Death-Adobting as an Example. Oral Presentation, 2^nd Congress of the Contemporary of Oncology, 21-24 April 2010, Poznan, Poland.

9. Saeid Ghavami, Mark M Mutawe, Karol McNeill, Geral Stelmack, Thomas klonisch, Grant hatch, Andrew J Halayko. Statin-triggered Cell Death in Primary Human Lung Mesenchymal Cells Involeves p53-PUMA and Release of Smac and Omi but not Cytochrome c. Oral presentation at the 16^th Annual Meeting of Society of the Free Radical Biology and medicine, 18-22 Novemeber 2009, San Francisco, USA.

1. Saeid Ghavami, Claus Kerkhoff, Walter J Chazin, Andrew J Halayko, Thomas Klonisch, Marek Los. Selected Oral Presentation in Young Investigator Award in 6^th Canadian Oxidative Stress Symposium, Winnipeg, Canada, May 6^th-9^th, 2009.

1. Saeid Ghavami , Andrew J. Halayko , Claus Kerkhoff,  Marek Los. Pro-apoptotic, pro-autophagy and proliferative effect of calprotectin. 12^th  Gliwice Scientific Meetings, 20-21 Nov 2009, Gliwice, Poland

2. Saeid Ghavami, Dedmar Schaafsma, Mark M Mutawe , Kristin Hauf, Karol D Mcnail, Gerald L Stelmack, H Unruh, Thomas Klonisch, Grant Hatch, Andrew J Halayko. Autophagy Protects Against Simvastatin-p53 induced cell death in airway mesenchymal cells. Poster presentation in Intenrational Advanced ICAS /ApopTrain course on Advances in Cell Death Research, From Bench to Desk.. Gunzburg, Germany, July 16-20, 2008.

3. Mohammad Hashemi, Hamid Mehrabifar, Mina Daliri, Saeid Ghavami. Serum Trypsin Inhibitory Capacity (TIC) And Adenosine Deaminase Activitiy In Patients With Psoriasis. The 9th Iranian Congress of Biochemistry & the 2nd International Congress of Biochemistry and Molecular Biology Shiraz-Iran, Oct.29-Nov, 1, 2007.

4. Mohammad Hashemi, Mohammad Naderi, Ali Mehdizadeh, Hamid Mehrabifar, Saeid Ghavami. Serum Adenosine Deaminase Activity In Tuberculosis And Non-Tuberculosis Respiratory Disease. The 9th Iranian Congress of Biochemistry & the 2nd International Congress of Biochemistry and Molecular Biology Shiraz-Iran, Oct.29-Nov, 1, 2007.

5.  Anne Zuse, Saeid Ghavami, Ahmad Asoodeh, Kamran Kadkhoda, Tadeusz J. Kroczak, Hossein Naderi-Manesh, Marek Los. Brevinin-2R, a peptide inducing semi-selectively cancer cell death by a mechanism involving the mitochondrial death pathway. AACR annual meeting, L.A, 14-18 April 2007, USA.

6.  Saeid Ghavami, Thomas Klonisch, Andrew Halayko, Kamran Kadkhoda, Tadeusz J. Kroczak , Marek Los. Brevinin-2R semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. Keystone Apoptotic and non-Apoptotic Cell Death Pathway. Syposia, 2007, April, 15-20, Monterey, USA.

7. Saeid Ghavami, Claus Kerkhoff, Walter J. Chazin, Kamran Kadkhoda, Mohammad Hashemi, Marek Los. Cell Death Signaling Pathway of S100A8/A9, - the RAGE, the Mitochondrial Pathway, and Modulation of the Balance between Pro-, and Antiapoptotic Bcl2-Family Members. Keystone Cell Signaling Symposia, 2007. March 22-27, Steamboatspring, USA.

8.  Saeid Ghavami, Claus Kerkhoff, Walter J Chazin, Mohammad Hashemi, Iran Rashedi, Marek Los. Death signaling pathway of human S100A8/A9. FOCIS. 2006, June, 2-7, San Diego, USA.