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Nobel Laureate Abel Laureate Advisory Board Member USERN President USERN Policy Making Council USERN Manager USERN Deputy Junior Ambassador
Major: Neuroscience & Behavior
Field: Cellular and molecular neuroscience
Harriman Professor of Neuroscience Research in Molecular, Cellular and Developmental Biology at UCSB Co-Director, Neuroscience Research Institute
Biography
Kenneth S. Kosik completed a B.A. and M.A. in English literature from Case Western Reserve University in 1972 and an M.D. from the Medical College of Pennsylvania in 1976. He served as a resident in neurology at Tufts New England Medical Center and was Chief Resident there in 1980. Beginning in 1980 he held a series of academic appointments at the Harvard Medical School and achieved the rank of full professor there in 1996. He also held appointments at McLean Hospital, Brigham and Women's Hospital, the Massachusetts General Hospital and the Dana-Farber Cancer Institute. In 2004, Kosik became the Harriman Professor of Neuroscience Research and Co-Director of the Neuroscience Research Institute at the University of California, Santa Barbara. He founded and serves as Medical Director of the non-profit center, Cottage Center for Brain Fitness (CCBF).
Research Topics
The Kosik lab intends to create an intellectual setting conducive to the exploration of fundamental biological processes, particularly those related to the brain and its evolution. Although the approach is largely reductionist with an emphasis on genes, molecules and cells, studies in the lab also encompass systems level informatic approaches that include large genomic and transcriptional and imaging data sets. One theme in the lab is how cells acquire and lose their identities. A specialized case of altered cellular identity is synaptic plasticity. The lab is interested in the underlying molecular basis of plasticity, particularly how protein translation at the synapse affects learning and how impairments of plasticity lead to neurodegenerative diseases. Behind all the lab projects stands the overarching principle succinctly stated by Theodosius Dobzhansky, "Nothing in Biology Makes Sense Except in the Light of Evolution."
Areas of Study
- Biomedical Sciences
- Cell Biology
- Developmental & Stem Cell Biology
- Genetics & Genomics
- Neuroscience
- Systems & Quantitative Biology
Honors & Awards
- Whitaker Health Sciences Award, Massachusetts Institute of Technology
- Metropolitan Life Foundation Medical Award
- Derek Denny-Brown Neurological Scholar Award, the American Neurological Association (1990)
- Zenith Award from the Alzheimer's Association
- Ranwell Caputo Medal, the Argentine Society of Neurochemistry
- NASA Group Achievement Award to the Neurolab Science Team
Publications
LRP1 is a master regulator of tau uptake and spread.
Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS.Nature. 2020 Apr;580(7803):381-385. doi: 10.1038/s41586-020-2156-5. Epub 2020 Apr 1.PMID: 32296178
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease.
Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, Miller BL, Berretta S, Hedreen JC, Grinberg LT, Seeley WW, Hyman BT, Steen H, Steen JA.Cell. 2020 Dec 10;183(6):1699-1713.e13. doi: 10.1016/j.cell.2020.10.029. Epub 2020 Nov 13.PMID: 33188775
Microglial microRNAs mediate sex-specific responses to tau pathology.
Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC, Clelland CD, Cheng Z, Yu G, Li Q, Kosik KS, Gan L.Nat Neurosci. 2020 Feb;23(2):167-171. doi: 10.1038/s41593-019-0560-7. Epub 2019 Dec 23.PMID: 31873194
Arboleda-Velasquez JF, Lopera F, O'Hare M, Delgado-Tirado S, Marino C, Chmielewska N, Saez-Torres KL, Amarnani D, Schultz AP, Sperling RA, Leyton-Cifuentes D, Chen K, Baena A, Aguillon D, Rios-Romenets S, Giraldo M, Guzmán-Vélez E, Norton DJ, Pardilla-Delgado E, Artola A, Sanchez JS, Acosta-Uribe J, Lalli M, Kosik KS, Huentelman MJ, Zetterberg H, Blennow K, Reiman RA, Luo J, Chen Y, Thiyyagura P, Su Y, Jun GR, Naymik M, Gai X, Bootwalla M, Ji J, Shen L, Miller JB, Kim LA, Tariot PN, Johnson KA, Reiman EM, Quiroz YT.Nat Med. 2019 Nov;25(11):1680-1683. doi: 10.1038/s41591-019-0611-3. Epub 2019 Nov 4.PMID: 31686034
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L.Neuron. 2019 Nov 6;104(3):458-470.e5. doi: 10.1016/j.neuron.2019.08.008. Epub 2019 Sep 18.PMID: 31542321
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S; Tau Consortium Stem Cell Group.Stem Cell Reports. 2019 Nov 12;13(5):939-955. doi: 10.1016/j.stemcr.2019.09.006. Epub 2019 Oct 17.PMID: 31631020
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.
Nowakowski TJ, Rani N, Golkaram M, Zhou HR, Alvarado B, Huch K, West JA, Leyrat A, Pollen AA, Kriegstein AR, Petzold LR, Kosik KS.Nat Neurosci. 2018 Dec;21(12):1784-1792. doi: 10.1038/s41593-018-0265-3. Epub 2018 Nov 19.PMID: 30455455
COVID-19 in older people with cognitive impairment in Latin America.
Ibanez A, Kosik KS; Latin America and the Caribbean Consortium on Dementia (LAC-CD).Lancet Neurol. 2020 Sep;19(9):719-721. doi: 10.1016/S1474-4422(20)30270-2.PMID: 32822627 No abstract available.
Synaptic dysregulation in a human iPS cell model of mental disorders.
Wen Z, Nguyen HN, Guo Z, Lalli MA, Wang X, Su Y, Kim NS, Yoon KJ, Shin J, Zhang C, Makri G, Nauen D, Yu H, Guzman E, Chiang CH, Yoritomo N, Kaibuchi K, Zou J, Christian KM, Cheng L, Ross CA, Margolis RL, Chen G, Kosik KS, Song H, Ming GL.Nature. 2014 Nov 20;515(7527):414-8. doi: 10.1038/nature13716. Epub 2014 Aug 17.PMID: 25132547
The proline-rich domain promotes Tau liquid-liquid phase separation in cells.
Zhang X, Vigers M, McCarty J, Rauch JN, Fredrickson GH, Wilson MZ, Shea JE, Han S, Kosik KS.J Cell Biol. 2020 Nov 2;219(11):e202006054. doi: 10.1083/jcb.202006054.PMID: 32997736
Kosik KS, Han S.Adv Exp Med Biol. 2019;1184:327-339. doi: 10.1007/978-981-32-9358-8_24.PMID: 32096047 Review.
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).
Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS.Sci Rep. 2018 Apr 23;8(1):6382. doi: 10.1038/s41598-018-24904-z.PMID: 29686391
A molecular signature for anastasis, recovery from the brink of apoptotic cell death.
Sun G, Guzman E, Balasanyan V, Conner CM, Wong K, Zhou HR, Kosik KS, Montell DJ.J Cell Biol. 2017 Oct 2;216(10):3355-3368. doi: 10.1083/jcb.201706134. Epub 2017 Aug 2.PMID: 28768686
Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS.Sci Transl Med. 2019 Mar 27;11(485):eaat3005. doi: 10.1126/scitranslmed.aat3005.PMID: 30918111
FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease.
Mair W, Muntel J, Tepper K, Tang S, Biernat J, Seeley WW, Kosik KS, Mandelkow E, Steen H, Steen JA.Anal Chem. 2016 Apr 5;88(7):3704-14. doi: 10.1021/acs.analchem.5b04509. Epub 2016 Mar 7.PMID: 26877193
MOV10 and FMRP regulate AGO2 association with microRNA recognition elements.
Kenny PJ, Zhou H, Kim M, Skariah G, Khetani RS, Drnevich J, Arcila ML, Kosik KS, Ceman S.Cell Rep. 2014 Dec 11;9(5):1729-1741. doi: 10.1016/j.celrep.2014.10.054. Epub 2014 Nov 20.PMID: 25464849
Evolution of New miRNAs and Cerebro-Cortical Development.
Kosik KS, Nowakowski T.Annu Rev Neurosci. 2018 Jul 8;41:119-137. doi: 10.1146/annurev-neuro-080317-061822. Epub 2018 Apr 4.PMID: 29618285 Review.
Cell biology in support of neurological research: 2018 highlights.
Kosik KS.Lancet Neurol. 2019 Jan;18(1):19-20. doi: 10.1016/S1474-4422(18)30462-9.PMID: 30563677 No abstract available.
Non-contact monitoring of extra-cellular field potentials with a multi-electrode array.
Sharf T, Hansma PK, Hari MA, Kosik KS.Lab Chip. 2019 Apr 9;19(8):1448-1457. doi: 10.1039/c8lc00984h.PMID: 30887972
In vitro validation of in silico identified inhibitory interactions.
Liu H, Bridges D, Randall C, Solla SA, Wu B, Hansma P, Yan X, Kosik KS, Bouchard K.J Neurosci Methods. 2019 Jun 1;321:39-48. doi: 10.1016/j.jneumeth.2019.04.002. Epub 2019 Apr 6.PMID: 30965073
The message and the messenger: delivering RNA in neurons.
Kosik KS, Krichevsky AM.Sci STKE. 2002 Apr 2;2002(126):pe16. doi: 10.1126/stke.2002.126.pe16.PMID: 11930084 Review.
MicroRNAs: regulators of oncogenesis and stemness.
Papagiannakopoulos T, Kosik KS.BMC Med. 2008 Jun 24;6:15. doi: 10.1186/1741-7015-6-15.PMID: 18577221 Review.
Kosik KS.Nat Rev Neurosci. 2003 Mar;4(3):234-9. doi: 10.1038/nrn1053.PMID: 12612636 Review.
Kosik KS.Cerebrum. 2015 May 1;2015:6. eCollection 2015 May-Jun.PMID: 26380035
MicroRNAs potentiate neural development.
Fineberg SK, Kosik KS, Davidson BL.Neuron. 2009 Nov 12;64(3):303-9. doi: 10.1016/j.neuron.2009.10.020.PMID: 19914179 Review.
Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions.
Lin Y, McCarty J, Rauch JN, Delaney KT, Kosik KS, Fredrickson GH, Shea JE, Han S.Elife. 2019 Apr 5;8:e42571. doi: 10.7554/eLife.42571.PMID: 30950394
Kosik KS.Nat Rev Neurosci. 2006 Dec;7(12):911-20. doi: 10.1038/nrn2037.PMID: 17115073 Review.
Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hanseeuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT.J Prev Alzheimers Dis. 2019;6(2):112-120. doi: 10.14283/jpad.2019.6.PMID: 30756118 Review.
Control over single-cell distribution of G1 lengths by WNT governs pluripotency.
Jang J, Han D, Golkaram M, Audouard M, Liu G, Bridges D, Hellander S, Chialastri A, Dey SS, Petzold LR, Kosik KS.PLoS Biol. 2019 Sep 26;17(9):e3000453. doi: 10.1371/journal.pbio.3000453. eCollection 2019 Sep.PMID: 31557150
Lin Y, Fichou Y, Longhini AP, Llanes LC, Yin P, Bazan GC, Kosik KS, Han S.J Mol Biol. 2021 Jan 22;433(2):166731. doi: 10.1016/j.jmb.2020.166731. Epub 2020 Dec 3.PMID: 33279579
A path toward understanding neurodegeneration.
Kosik KS, Sejnowski TJ, Raichle ME, Ciechanover A, Baltimore D.Science. 2016 Aug 26;353(6302):872-3. doi: 10.1126/science.aai7622.PMID: 27563087
Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr).
Ramirez Aguilar L, Acosta-Uribe J, Giraldo MM, Moreno S, Baena A, Alzate D, Cuastumal R, Aguillón D, Madrigal L, Saldarriaga A, Navarro A, Garcia GP, Aguirre-Acevedo DC, Geier EG, Cochran JN, Quiroz YT, Myers RM, Yokoyama JS, Kosik KS, Lopera F.Alzheimers Dement. 2019 May;15(5):709-719. doi: 10.1016/j.jalz.2018.12.010. Epub 2019 Feb 10.PMID: 30745123
The outer subventricular zone and primate-specific cortical complexification.
Dehay C, Kennedy H, Kosik KS.Neuron. 2015 Feb 18;85(4):683-94. doi: 10.1016/j.neuron.2014.12.060.PMID: 25695268 Review.
MicroRNAs tell an evo-devo story.
Kosik KS.Nat Rev Neurosci. 2009 Oct;10(10):754-9. doi: 10.1038/nrn2713. Epub 2009 Sep 9.PMID: 19738624 Review.
Tau protein and neurodegeneration.
Kosik KS.Mol Neurobiol. 1990 Fall-Winter;4(3-4):171-9. doi: 10.1007/BF02780339.PMID: 2135393 Review.
Ibanez A, Santamaria-Garcia H, Guerrero Barragan A, Kornhuber A, Ton AMM, Slachevsky A, Teixeira AL, Mar Meza BM, Serrano CM, Cano C, Arias Gonzalez C, Gonzalez-Billault C, Butler C, Bustin J, Duran-Aniotz C, Acosta D, Matallana DL, Acosta-Alvear D, Trépel D, Resende EPF, de Oliveira FF, Ibanez F, De Felice FG, Navarrete G, Tarnanas I, Meier IB, Smid J, Llibre-Guerra J, Llibre-Rodriguez JJ, Fajersztajn L, Takada LT, Duque L, Okada de Oliveira M, Bicalho MAC, Behrens MI, Pintado-Caipa M, Parra M, Wilson MZ, De La Cruz Puebla M, Custodio N, Santibanez R, Serafim RB, Tavares RM, Piña Escudero SD, Leon Rodriguez T, Dawson W, Miller BL, Kosik KS.Alzheimers Dement (N Y). 2020 Nov 23;6(1):e12092. doi: 10.1002/trc2.12092. eCollection 2020.PMID: 33283036
Delta-catenin at the synaptic-adherens junction.
Kosik KS, Donahue CP, Israely I, Liu X, Ochiishi T.Trends Cell Biol. 2005 Mar;15(3):172-8. doi: 10.1016/j.tcb.2005.01.004.PMID: 15752981 Review.
Phosphorylated tau and the neurodegenerative foldopathies.
Kosik KS, Shimura H.Biochim Biophys Acta. 2005 Jan 3;1739(2-3):298-310. doi: 10.1016/j.bbadis.2004.10.011. Epub 2004 Nov 26.PMID: 15615647 Review.
Noncoding RNAs in Long-Term Memory Formation.
Mercer TR, Dinger ME, Mariani J, Kosik KS, Mehler MF, Mattick JS.Neuroscientist. 2008 Oct;14(5):434-45. doi: 10.1177/1073858408319187.PMID: 18997122 Review.
Martin KC, Kosik KS.Nat Rev Neurosci. 2002 Oct;3(10):813-20. doi: 10.1038/nrn942.PMID: 12360325 Review. No abstract available.
Cofactors are essential constituents of stable and seeding-active tau fibrils.
Fichou Y, Lin Y, Rauch JN, Vigers M, Zeng Z, Srivastava M, Keller TJ, Freed JH, Kosik KS, Han S.Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13234-13239. doi: 10.1073/pnas.1810058115. Epub 2018 Dec 11.PMID: 30538196
RNA stores tau reversibly in complex coacervates.
Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I, Guzman E, Kosik KS, Han S.PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul.PMID: 28683104
Mechanisms of age-related cognitive change and targets for intervention: epigenetics.
Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH.J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):741-6. doi: 10.1093/gerona/gls110. Epub 2012 Apr 20.PMID: 22522509 Review.
Life at Low Copy Number: How Dendrites Manage with So Few mRNAs.
Kosik KS.Neuron. 2016 Dec 21;92(6):1168-1180. doi: 10.1016/j.neuron.2016.11.002.PMID: 28009273 Review.
Mendivil-Perez M, Velez-Pardo C, Kosik KS, Lopera F, Jimenez-Del-Rio M.Neurosci Lett. 2019 Jun 11;703:111-118. doi: 10.1016/j.neulet.2019.03.032. Epub 2019 Mar 20.PMID: 30904577
MicroRNA regulation of neural stem cells and neurogenesis.
Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S, Neveu P, Kosik KS.J Neurosci. 2010 Nov 10;30(45):14931-6. doi: 10.1523/JNEUROSCI.4280-10.2010.PMID: 21068294 Review.
The Elegance of the MicroRNAs: A Neuronal Perspective.
Kosik KS, Krichevsky AM.Neuron. 2005 Sep 15;47(6):779-82. doi: 10.1016/j.neuron.2005.08.019.PMID: 16157272 Review.
Tau protein and Alzheimer's disease.
Kosik KS.Curr Opin Cell Biol. 1990 Feb;2(1):101-4. doi: 10.1016/s0955-0674(05)80038-9.PMID: 2109621 Review. No abstract available.
Neurodegeneration: new clues on inclusions.
Lansbury PT Jr, Kosik KS.Chem Biol. 2000 Jan;7(1):R9-R12. doi: 10.1016/s1074-5521(00)00068-5.PMID: 10662685 Review.
MicroRNAs and cellular phenotypy.
Kosik KS.Cell. 2010 Oct 1;143(1):21-6. doi: 10.1016/j.cell.2010.09.008.PMID: 20887887
MEA Viewer: A high-performance interactive application for visualizing electrophysiological data.
Bridges DC, Tovar KR, Wu B, Hansma PK, Kosik KS.PLoS One. 2018 Feb 9;13(2):e0192477. doi: 10.1371/journal.pone.0192477. eCollection 2018.PMID: 29425223
MicroRNA-124: micromanager of neurogenesis.
Papagiannakopoulos T, Kosik KS.Cell Stem Cell. 2009 May 8;4(5):375-6. doi: 10.1016/j.stem.2009.04.007.PMID: 19427286
Parallel discovery of Alzheimer's therapeutics.
Lo AW, Ho C, Cummings J, Kosik KS.Sci Transl Med. 2014 Jun 18;6(241):241cm5. doi: 10.1126/scitranslmed.3008228.PMID: 24944190
Alzheimer's disease: a cell biological perspective.
Kosik KS.Science. 1992 May 8;256(5058):780-3. doi: 10.1126/science.1589757.PMID: 1589757 Review.
Tau immunization: a cautionary tale?
Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM.Neurobiol Aging. 2015 Mar;36(3):1316-32. doi: 10.1016/j.neurobiolaging.2014.11.022. Epub 2014 Dec 30.PMID: 25619661
Exploring the early origins of the synapse by comparative genomics.
Kosik KS.Biol Lett. 2009 Feb 23;5(1):108-11. doi: 10.1098/rsbl.2008.0594.PMID: 19049956 Review.
New approaches to the discovery of cdk5 inhibitors.
Glicksman MA, Cuny GD, Liu M, Dobson B, Auerbach K, Stein RL, Kosik KS.Curr Alzheimer Res. 2007 Dec;4(5):547-9. doi: 10.2174/156720507783018181.PMID: 18220519 Review.
Action potential propagation recorded from single axonal arbors using multielectrode arrays.
Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS.J Neurophysiol. 2018 Jul 1;120(1):306-320. doi: 10.1152/jn.00659.2017. Epub 2018 Apr 11.PMID: 29641308
Personalized medicine for effective Alzheimer disease treatment.
Kosik KS.JAMA Neurol. 2015 May;72(5):497-8. doi: 10.1001/jamaneurol.2014.3445.PMID: 25730751 No abstract available.
Detection of Prokaryotic Genes in the Amphimedon queenslandica Genome.
Conaco C, Tsoulfas P, Sakarya O, Dolan A, Werren J, Kosik KS.PLoS One. 2016 Mar 9;11(3):e0151092. doi: 10.1371/journal.pone.0151092. eCollection 2016.PMID: 26959231
Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments.
Reiman EM, Langbaum JB, Fleisher AS, Caselli RJ, Chen K, Ayutyanont N, Quiroz YT, Kosik KS, Lopera F, Tariot PN.J Alzheimers Dis. 2011;26 Suppl 3(Suppl 3):321-9. doi: 10.3233/JAD-2011-0059.PMID: 21971471 Review.
The molecular and cellular biology of tau.
Kosik KS.Brain Pathol. 1993 Jan;3(1):39-43. doi: 10.1111/j.1750-3639.1993.tb00724.x.PMID: 8269082 Review.
A microRNA-mRNA expression network during oral siphon regeneration in Ciona.
Spina EJ, Guzman E, Zhou H, Kosik KS, Smith WC.Development. 2017 May 15;144(10):1787-1797. doi: 10.1242/dev.144097. Epub 2017 Apr 21.PMID: 28432214
PhDs: what's left if science abdicates?
Kosik KS.Nature. 2011 May 19;473(7347):284. doi: 10.1038/473284b.PMID: 21593846 No abstract available.
SMN regulates axonal local translation via miR-183/mTOR pathway.
Kye MJ, Niederst ED, Wertz MH, Gonçalves Ido C, Akten B, Dover KZ, Peters M, Riessland M, Neveu P, Wirth B, Kosik KS, Sardi SP, Monani UR, Passini MA, Sahin M.Hum Mol Genet. 2014 Dec 1;23(23):6318-31. doi: 10.1093/hmg/ddu350. Epub 2014 Jul 4.PMID: 25055867
MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth.
DiTella MC, Feiguin F, Carri N, Kosik KS, Cáceres A.J Cell Sci. 1996 Feb;109 ( Pt 2):467-77.PMID: 8838670
Staged miRNA re-regulation patterns during reprogramming.
Henzler CM, Li Z, Dang J, Arcila ML, Zhou H, Liu J, Chang KY, Bassett DS, Rana TM, Kosik KS.Genome Biol. 2013 Dec 31;14(12):R149. doi: 10.1186/gb-2013-14-12-r149.PMID: 24380417
Age-related modifications of MAP-2.
Kosik KS, Bakalis S, Galibert L, Selkoe DJ, Duffy LK.Ann N Y Acad Sci. 1986;466:420-2. doi: 10.1111/j.1749-6632.1986.tb38412.x.PMID: 2873778 No abstract available.
Reconstructing ancestral genome content based on symmetrical best alignments and Dollo parsimony.
Sakarya O, Kosik KS, Oakley TH.Bioinformatics. 2008 Mar 1;24(5):606-12. doi: 10.1093/bioinformatics/btn005. Epub 2008 Jan 9.PMID: 18184685
Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs.
Corbel C, Hernandez I, Wu B, Kosik KS.Neural Dev. 2015 Sep 17;10:20. doi: 10.1186/s13064-015-0047-5.PMID: 26381867
Diseases: Study neuron networks to tackle Alzheimer's.
Kosik KS.Nature. 2013 Nov 7;503(7474):31-2. doi: 10.1038/503031a.PMID: 24218661 No abstract available.
Molecular biology: Circles reshape the RNA world.
Kosik KS.Nature. 2013 Mar 21;495(7441):322-4. doi: 10.1038/nature11956. Epub 2013 Feb 27.PMID: 23446351 No abstract available.
In vivo phosphorylation sites in fetal and adult rat tau.
Watanabe A, Hasegawa M, Suzuki M, Takio K, Morishima-Kawashima M, Titani K, Arai T, Kosik KS, Ihara Y.J Biol Chem. 1993 Dec 5;268(34):25712-7.PMID: 8245007
The Alzheimer's disease sphinx: a riddle with plaques and tangles.
Kosik KS.J Cell Biol. 1994 Dec;127(6 Pt 1):1501-4. doi: 10.1083/jcb.127.6.1501.PMID: 7798306 Review. No abstract available.
The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation.
Golkaram M, Jang J, Hellander S, Kosik KS, Petzold LR.Sci Rep. 2017 Oct 17;7(1):13307. doi: 10.1038/s41598-017-13731-3.PMID: 29042584
Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.
Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ.Neuron. 2015 Jun 3;86(5):1215-27. doi: 10.1016/j.neuron.2015.05.005. Epub 2015 May 21.PMID: 26004914
Along the way to a neurofibrillary tangle: a look at the structure of tau.
Kosik KS, Kowall NW, McKee A.Ann Med. 1989;21(2):109-12. doi: 10.3109/07853898909149195.PMID: 2504256 Review.
Homozygosity of the autosomal dominant Alzheimer disease presenilin 1 E280A mutation.
Kosik KS, Muñoz C, Lopez L, Arcila ML, García G, Madrigal L, Moreno S, Ríos Romenets S, Lopez H, Gutierrez M, Langbaum JB, Cho W, Suliman S, Tariot PN, Ho C, Reiman EM, Lopera F.Neurology. 2015 Jan 13;84(2):206-8. doi: 10.1212/WNL.0000000000001130. Epub 2014 Dec 3.PMID: 25471389 No abstract available.
Dementia in Latin America: Paving the way toward a regional action plan.
Parra MA, Baez S, Sedeño L, Gonzalez Campo C, Santamaría-García H, Aprahamian I, Bertolucci PH, Bustin J, Camargos Bicalho MA, Cano-Gutierrez C, Caramelli P, Chaves MLF, Cogram P, Beber BC, Court FA, de Souza LC, Custodio N, Damian A, de la Cruz M, Diehl Rodriguez R, Brucki SMD, Fajersztajn L, Farías GA, De Felice FG, Ferrari R, de Oliveira FF, Ferreira ST, Ferretti C, Figueredo Balthazar ML, Ferreira Frota NA, Fuentes P, García AM, Garcia PJ, de Gobbi Porto FH, Duque Peñailillo L, Engler HW, Maier I, Mata IF, Gonzalez-Billault C, Lopez OL, Morelli L, Nitrini R, Quiroz YT, Guerrero Barragan A, Huepe D, Pio FJ, Suemoto CK, Kochhann R, Kochen S, Kumfor F, Lanata S, Miller B, Mansur LL, Hosogi ML, Lillo P, Llibre Guerra J, Lira D, Lopera F, Comas A, Avila-Funes JA, Sosa AL, Ramos C, Resende EPF, Snyder HM, Tarnanas I, Yokoyama J, Llibre J, Cardona JF, Possin K, Kosik KS, Montesinos R, Moguilner S, Solis PCL, Ferretti-Rebustini REL, Ramirez JM, Matallana D, Mbakile-Mahlanza L, Marques Ton AM, Tavares RM, Miotto EC, Muniz-Terrera G, Muñoz-Nevárez LA, Orozco D, Okada de Oliveira M, Piguet O, Pintado Caipa M, Piña Escudero SD, Schilling LP, Rodrigues Palmeira AL, Yassuda MS, Santacruz-Escudero JM, Serafim RB, Smid J, Slachevsky A, Serrano C, Soto-Añari M, Takada LT, Grinberg LT, Teixeira AL, Barbosa MT, Trépel D, Ibanez A.Alzheimers Dement. 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202. Epub 2020 Nov 20.PMID: 33634602
Lisi V, Singh B, Giroux M, Guzman E, Painter MW, Cheng YC, Huebner E, Coppola G, Costigan M, Woolf CJ, Kosik KS.Cell Rep. 2017 Aug 1;20(5):1136-1147. doi: 10.1016/j.celrep.2017.07.010.PMID: 28768198
Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.
Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ.Neuron. 2016 May 4;90(3):662. doi: 10.1016/j.neuron.2016.04.025.PMID: 27151643 No abstract available.
Deep annotation of mouse iso-miR and iso-moR variation.
Zhou H, Arcila ML, Li Z, Lee EJ, Henzler C, Liu J, Rana TM, Kosik KS.Nucleic Acids Res. 2012 Jul;40(13):5864-75. doi: 10.1093/nar/gks247. Epub 2012 Mar 19.PMID: 22434881
A Scalable, Easy-to-Deploy Protocol for Cas13-Based Detection of SARS-CoV-2 Genetic Material.
Rauch JN, Valois E, Solley SC, Braig F, Lach RS, Audouard M, Ponce-Rojas JC, Costello MS, Baxter NJ, Kosik KS, Arias C, Acosta-Alvear D, Wilson MZ.J Clin Microbiol. 2021 Mar 19;59(4):e02402-20. doi: 10.1128/JCM.02402-20. Print 2021 Mar 19.PMID: 33478979
Particle display: a quantitative screening method for generating high-affinity aptamers.
Wang J, Gong Q, Maheshwari N, Eisenstein M, Arcila ML, Kosik KS, Soh HT.Angew Chem Int Ed Engl. 2014 May 5;53(19):4796-801. doi: 10.1002/anie.201309334. Epub 2014 Mar 18.PMID: 24644057
Functionalization of a protosynaptic gene expression network.
Conaco C, Bassett DS, Zhou H, Arcila ML, Degnan SM, Degnan BM, Kosik KS.Proc Natl Acad Sci U S A. 2012 Jun 26;109 Suppl 1(Suppl 1):10612-8. doi: 10.1073/pnas.1201890109. Epub 2012 Jun 20.PMID: 22723359
Tracking Down Mutations Cell by Cell.
Kosik KS.Neuron. 2016 Mar 16;89(6):1126-1127. doi: 10.1016/j.neuron.2016.02.042.PMID: 26985720
Identification of piRNAs in the central nervous system.
Lee EJ, Banerjee S, Zhou H, Jammalamadaka A, Arcila M, Manjunath BS, Kosik KS.RNA. 2011 Jun;17(6):1090-9. doi: 10.1261/rna.2565011. Epub 2011 Apr 22.PMID: 21515829
Hollingsworth EW, Vaughn JE, Orack JC, Skinner C, Khouri J, Lizarraga SB, Hester ME, Watanabe F, Kosik KS, Imitola J.EMBO Mol Med. 2017 Dec;9(12):1742-1762. doi: 10.15252/emmm.201708191.PMID: 29051230
NMDA mediated contextual conditioning changes miRNA expression.
Kye MJ, Neveu P, Lee YS, Zhou M, Steen JA, Sahin M, Kosik KS, Silva AJ.PLoS One. 2011;6(9):e24682. doi: 10.1371/journal.pone.0024682. Epub 2011 Sep 12.PMID: 21931811
RNAi functions in cultured mammalian neurons.
Krichevsky AM, Kosik KS.Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11926-9. doi: 10.1073/pnas.182272699. Epub 2002 Aug 21.PMID: 12192088
Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization.
Baas PW, Pienkowski TP, Kosik KS.J Cell Biol. 1991 Dec;115(5):1333-44. doi: 10.1083/jcb.115.5.1333.PMID: 1955477
Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.
Laha JK, Zhang X, Qiao L, Liu M, Chatterjee S, Robinson S, Kosik KS, Cuny GD.Bioorg Med Chem Lett. 2011 Apr 1;21(7):2098-101. doi: 10.1016/j.bmcl.2011.01.140. Epub 2011 Feb 3.PMID: 21353545
Lalli MA, Jang J, Park JH, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D, Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS.Hum Mol Genet. 2016 Apr 1;25(7):1294-306. doi: 10.1093/hmg/ddw010. Epub 2016 Jan 10.PMID: 26755828
A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA.
Rani N, Nowakowski TJ, Zhou H, Godshalk SE, Lisi V, Kriegstein AR, Kosik KS.Neuron. 2016 Jun 15;90(6):1174-1188. doi: 10.1016/j.neuron.2016.05.005. Epub 2016 Jun 2.PMID: 27263970
Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.
Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL.Cell Rep. 2015 Sep 1;12(9):1414-29. doi: 10.1016/j.celrep.2015.07.061. Epub 2015 Aug 20.PMID: 26299970
Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease.
Lalli MA, Cox HC, Arcila ML, Cadavid L, Moreno S, Garcia G, Madrigal L, Reiman EM, Arcos-Burgos M, Bedoya G, Brunkow ME, Glusman G, Roach JC, Hood L, Kosik KS, Lopera F.Alzheimers Dement. 2014 Oct;10(5 Suppl):S277-S283.e10. doi: 10.1016/j.jalz.2013.09.005. Epub 2013 Nov 13.PMID: 24239249
Cellular aspects of Alzheimer neurofibrillary pathology.
Kosik KS.Prog Clin Biol Res. 1992;379:183-93.PMID: 1409744 Review. No abstract available.
Hirano bodies contain tau protein.
Galloway PG, Perry G, Kosik KS, Gambetti P.Brain Res. 1987 Feb 17;403(2):337-40. doi: 10.1016/0006-8993(87)90071-0.PMID: 3103867
Piedrahita D, Castro-Alvarez JF, Boudreau RL, Villegas-Lanau A, Kosik KS, Gallego-Gomez JC, Cardona-Gómez GP.Front Cell Neurosci. 2016 Jan 8;9:498. doi: 10.3389/fncel.2015.00498. eCollection 2015.PMID: 26778963
Jang J, Wang Y, Lalli MA, Guzman E, Godshalk SE, Zhou H, Kosik KS.Cell. 2016 Apr 7;165(2):410-20. doi: 10.1016/j.cell.2016.02.014. Epub 2016 Mar 24.PMID: 27020754
Traveling the tau pathway: a personal account.
Kosik KS.J Alzheimers Dis. 2006;9(3 Suppl):251-6. doi: 10.3233/jad-2006-9s327.PMID: 16914863 Review.
Arcila ML, Betizeau M, Cambronne XA, Guzman E, Doerflinger N, Bouhallier F, Zhou H, Wu B, Rani N, Bassett DS, Borello U, Huissoud C, Goodman RH, Dehay C, Kosik KS.Neuron. 2014 Mar 19;81(6):1255-1262. doi: 10.1016/j.neuron.2014.01.017. Epub 2014 Feb 27.PMID: 24583023
Ponce-Rojas JC, Costello MS, Proctor DA, Kosik KS, Wilson MZ, Arias C, Acosta-Alvear D.J Clin Microbiol. 2021 Mar 19;59(4):e02403-20. doi: 10.1128/JCM.02403-20. Print 2021 Mar 19.PMID: 33293367
Statistical analysis of dendritic spine distributions in rat hippocampal cultures.
Jammalamadaka A, Banerjee S, Manjunath BS, Kosik KS.BMC Bioinformatics. 2013 Oct 2;14:287. doi: 10.1186/1471-2105-14-287.PMID: 24088199
The Amphimedon queenslandica genome and the evolution of animal complexity.
Srivastava M, Simakov O, Chapman J, Fahey B, Gauthier ME, Mitros T, Richards GS, Conaco C, Dacre M, Hellsten U, Larroux C, Putnam NH, Stanke M, Adamska M, Darling A, Degnan SM, Oakley TH, Plachetzki DC, Zhai Y, Adamski M, Calcino A, Cummins SF, Goodstein DM, Harris C, Jackson DJ, Leys SP, Shu S, Woodcroft BJ, Vervoort M, Kosik KS, Manning G, Degnan BM, Rokhsar DS.Nature. 2010 Aug 5;466(7307):720-6. doi: 10.1038/nature09201.PMID: 20686567
Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ.Stem Cell Reports. 2016 Sep 13;7(3):325-340. doi: 10.1016/j.stemcr.2016.08.001. Epub 2016 Sep 1.PMID: 27594585
Corbel C, Zhang B, Le Parc A, Baratte B, Colas P, Couturier C, Kosik KS, Landrieu I, Le Tilly V, Bach S.Chem Biol. 2015 Apr 23;22(4):472-482. doi: 10.1016/j.chembiol.2015.03.009. Epub 2015 Apr 9.PMID: 25865311
A quantitative framework to evaluate modeling of cortical development by neural stem cells.
Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH.Neuron. 2014 Jul 2;83(1):69-86. doi: 10.1016/j.neuron.2014.05.035.PMID: 24991955
Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models.
Zhang X, Hernandez I, Rei D, Mair W, Laha JK, Cornwell ME, Cuny GD, Tsai LH, Steen JA, Kosik KS.J Biol Chem. 2013 Jul 26;288(30):22042-56. doi: 10.1074/jbc.M112.436402. Epub 2013 Jun 4.PMID: 23737518
Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH.Alzheimers Dement (Amst). 2016 Jun 22;3:91-7. doi: 10.1016/j.dadm.2016.05.004. eCollection 2016.PMID: 27453930
Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y.Stem Cell Reports. 2013 Aug 29;1(3):226-34. doi: 10.1016/j.stemcr.2013.08.001. eCollection 2013.PMID: 24319659
Regulation of AMPA receptor trafficking by delta-catenin.
Ochiishi T, Futai K, Okamoto K, Kameyama K, Kosik KS.Mol Cell Neurosci. 2008 Dec;39(4):499-507. doi: 10.1016/j.mcn.2008.06.002. Epub 2008 Jun 17.PMID: 18602475
Castro-Alvarez JF, Uribe-Arias SA, Kosik KS, Cardona-Gómez GP.Front Aging Neurosci. 2014 Sep 10;6:243. doi: 10.3389/fnagi.2014.00243. eCollection 2014.PMID: 25309427
Evolutionary expansion and specialization of the PDZ domains.
Sakarya O, Conaco C, Egecioglu O, Solla SA, Oakley TH, Kosik KS.Mol Biol Evol. 2010 May;27(5):1058-69. doi: 10.1093/molbev/msp311. Epub 2009 Dec 21.PMID: 20026484
Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice.
Piedrahita D, Hernández I, López-Tobón A, Fedorov D, Obara B, Manjunath BS, Boudreau RL, Davidson B, Laferla F, Gallego-Gómez JC, Kosik KS, Cardona-Gómez GP.J Neurosci. 2010 Oct 20;30(42):13966-76. doi: 10.1523/JNEUROSCI.3637-10.2010.PMID: 20962218
Jang J, Wang Y, Kim HS, Lalli MA, Kosik KS.Stem Cells. 2014 Oct;32(10):2616-25. doi: 10.1002/stem.1764.PMID: 24895273
CADASIL mutations impair Notch3 glycosylation by Fringe.
Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS.Hum Mol Genet. 2005 Jun 15;14(12):1631-9. doi: 10.1093/hmg/ddi171. Epub 2005 Apr 27.PMID: 15857853
Discovery of compounds that will prevent tau pathology.
Kosik KS, Ahn J, Stein R, Yeh LA.J Mol Neurosci. 2002 Dec;19(3):261-6. doi: 10.1385/JMN:19:3:261.PMID: 12540051 Review.
Lalli MA, Bettcher BM, Arcila ML, Garcia G, Guzman C, Madrigal L, Ramirez L, Acosta-Uribe J, Baena A, Wojta KJ, Coppola G, Fitch R, de Both MD, Huentelman MJ, Reiman EM, Brunkow ME, Glusman G, Roach JC, Kao AW, Lopera F, Kosik KS.Mol Psychiatry. 2015 Nov;20(11):1294-300. doi: 10.1038/mp.2015.131. Epub 2015 Sep 1.PMID: 26324103
Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers.
Lalli MA, Garcia G, Madrigal L, Arcos-Burgos M, Arcila ML, Kosik KS, Lopera F.Hum Mutat. 2012 Dec;33(12):1630-4. doi: 10.1002/humu.22167. Epub 2012 Aug 10.PMID: 22829467
Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.
Papagiannakopoulos T, Friedmann-Morvinski D, Neveu P, Dugas JC, Gill RM, Huillard E, Liu C, Zong H, Rowitch DH, Barres BA, Verma IM, Kosik KS.Oncogene. 2012 Apr 12;31(15):1884-95. doi: 10.1038/onc.2011.380. Epub 2011 Aug 29.PMID: 21874051
A delta-catenin signaling pathway leading to dendritic protrusions.
Abu-Elneel K, Ochiishi T, Medina M, Remedi M, Gastaldi L, Caceres A, Kosik KS.J Biol Chem. 2008 Nov 21;283(47):32781-91. doi: 10.1074/jbc.M804688200. Epub 2008 Sep 22.PMID: 18809680
Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
Krichevsky AM, Sonntag KC, Isacson O, Kosik KS.Stem Cells. 2006 Apr;24(4):857-64. doi: 10.1634/stemcells.2005-0441. Epub 2005 Dec 15.PMID: 16357340
Heterogeneous dysregulation of microRNAs across the autism spectrum.
Abu-Elneel K, Liu T, Gazzaniga FS, Nishimura Y, Wall DP, Geschwind DH, Lao K, Kosik KS.Neurogenetics. 2008 Jul;9(3):153-61. doi: 10.1007/s10048-008-0133-5. Epub 2008 Jun 19.PMID: 18563458
MicroRNA profiling of the murine hematopoietic system.
Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS.Genome Biol. 2005;6(8):R71. doi: 10.1186/gb-2005-6-8-r71. Epub 2005 Aug 1.PMID: 16086853
MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.
Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS.Cell Stem Cell. 2010 Dec 3;7(6):671-81. doi: 10.1016/j.stem.2010.11.012.PMID: 21112562
Tau protein and the establishment of an axonal morphology.
Kosik KS, Caceres A.J Cell Sci Suppl. 1991;15:69-74. doi: 10.1242/jcs.1991.supplement_15.10.PMID: 1668596 Review.
A post-synaptic scaffold at the origin of the animal kingdom.
Sakarya O, Armstrong KA, Adamska M, Adamski M, Wang IF, Tidor B, Degnan BM, Oakley TH, Kosik KS.PLoS One. 2007 Jun 6;2(6):e506. doi: 10.1371/journal.pone.0000506.PMID: 17551586
The molecular and cellular pathology of Alzheimer neurofibrillary lesions.
Kosik KS.J Gerontol. 1989 May;44(3):B55-8. doi: 10.1093/geronj/44.3.b55.PMID: 2497170 Review. No abstract available.
Smagghe BJ, Stewart AK, Carter MG, Shelton LM, Bernier KJ, Hartman EJ, Calhoun AK, Hatziioannou VM, Lillacci G, Kirk BA, DiNardo BA, Kosik KS, Bamdad C.PLoS One. 2013;8(3):e58601. doi: 10.1371/journal.pone.0058601. Epub 2013 Mar 7.PMID: 23505541
Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology.
Yuraszeck TM, Neveu P, Rodriguez-Fernandez M, Robinson A, Kosik KS, Doyle FJ 3rd.PLoS Comput Biol. 2010 Nov 11;6(11):e1000997. doi: 10.1371/journal.pcbi.1000997.PMID: 21085645
Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation.
Krichevsky AM, Kosik KS.Neuron. 2001 Nov 20;32(4):683-96. doi: 10.1016/s0896-6273(01)00508-6.PMID: 11719208
Public attitudes about genetic testing for Alzheimer's disease.
Neumann PJ, Hammitt JK, Mueller C, Fillit HM, Hill J, Tetteh NA, Kosik KS.Health Aff (Millwood). 2001 Sep-Oct;20(5):252-64. doi: 10.1377/hlthaff.20.5.252.PMID: 11558711
Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR.
Kye MJ, Liu T, Levy SF, Xu NL, Groves BB, Bonneau R, Lao K, Kosik KS.RNA. 2007 Aug;13(8):1224-34. doi: 10.1261/rna.480407. Epub 2007 Jun 25.PMID: 17592044
A tau promoter region without neuronal specificity.
Andreadis A, Wagner BK, Broderick JA, Kosik KS.J Neurochem. 1996 Jun;66(6):2257-63. doi: 10.1046/j.1471-4159.1996.66062257.x.PMID: 8632146
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
Carrettiero DC, Hernandez I, Neveu P, Papagiannakopoulos T, Kosik KS.J Neurosci. 2009 Feb 18;29(7):2151-61. doi: 10.1523/JNEUROSCI.4660-08.2009.PMID: 19228967
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
Chan JA, Krichevsky AM, Kosik KS.Cancer Res. 2005 Jul 15;65(14):6029-33. doi: 10.1158/0008-5472.CAN-05-0137.PMID: 16024602
Accelerated neuronal differentiation induced by p53 suppression.
Ferreira A, Kosik KS.J Cell Sci. 1996 Jun;109 ( Pt 6):1509-16.PMID: 8799837
Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells.
Kosik KS, McConlogue L.Cell Motil Cytoskeleton. 1994;28(3):195-8. doi: 10.1002/cm.970280302.PMID: 7954847 Review.
MUC1* mediates the growth of human pluripotent stem cells.
Hikita ST, Kosik KS, Clegg DO, Bamdad C.PLoS One. 2008 Oct 3;3(10):e3312. doi: 10.1371/journal.pone.0003312.PMID: 18833326
Development of a fluorescent high throughput assay for tau aggregation.
Liu M, Ni J, Kosik KS, Yeh LA.Assay Drug Dev Technol. 2004 Dec;2(6):609-19. doi: 10.1089/adt.2004.2.609.PMID: 15674019
Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS.Cell. 2009 May 15;137(4):647-58. doi: 10.1016/j.cell.2009.02.038. Epub 2009 Apr 30.PMID: 19409607
Transcriptional profiling reveals regulated genes in the hippocampus during memory formation.
Donahue CP, Jensen RV, Ochiishi T, Eisenstein I, Zhao M, Shors T, Kosik KS.Hippocampus. 2002;12(6):821-33. doi: 10.1002/hipo.10058.PMID: 12542233
Ibanez A, Yokoyama JS, Possin KL, Matallana D, Lopera F, Nitrini R, Takada LT, Custodio N, Sosa Ortiz AL, Avila-Funes JA, Behrens MI, Slachevsky A, Myers RM, Cochran JN, Brusco LI, Bruno MA, Brucki SMD, Pina-Escudero SD, Okada de Oliveira M, Donnelly Kehoe P, Garcia AM, Cardona JF, Santamaria-Garcia H, Moguilner S, Duran-Aniotz C, Tagliazucchi E, Maito M, Longoria Ibarrola EM, Pintado-Caipa M, Godoy ME, Bakman V, Javandel S, Kosik KS, Valcour V, Miller BL.Front Neurol. 2021 Mar 11;12:631722. doi: 10.3389/fneur.2021.631722. eCollection 2021.PMID: 33776890 Review.
Intraneuronal compartments of the amyloid precursor protein.
Ferreira A, Caceres A, Kosik KS.J Neurosci. 1993 Jul;13(7):3112-23. doi: 10.1523/JNEUROSCI.13-07-03112.1993.PMID: 8331388
The microtubule binding domain of tau protein.
Lee G, Neve RL, Kosik KS.Neuron. 1989 Jun;2(6):1615-24. doi: 10.1016/0896-6273(89)90050-0.PMID: 2516729
Temple MD, Kosik KS, Steward O.Neurobiol Learn Mem. 2002 Sep;78(2):199-216. doi: 10.1006/nlme.2001.4049.PMID: 12431413
BACE1 suppression by RNA interference in primary cortical neurons.
Kao SC, Krichevsky AM, Kosik KS, Tsai LH.J Biol Chem. 2004 Jan 16;279(3):1942-9. doi: 10.1074/jbc.M309219200. Epub 2003 Nov 3.PMID: 14600149
Vélez JI, Chandrasekharappa SC, Henao E, Martinez AF, Harper U, Jones M, Solomon BD, Lopez L, Garcia G, Aguirre-Acevedo DC, Acosta-Baena N, Correa JC, Lopera-Gómez CM, Jaramillo-Elorza MC, Rivera D, Kosik KS, Schork NJ, Swanson JM, Lopera F, Arcos-Burgos M.Mol Psychiatry. 2013 May;18(5):568-75. doi: 10.1038/mp.2012.81. Epub 2012 Jun 19.PMID: 22710270
Senile plaques are located between apical dendritic clusters.
Kosik KS, Rogers J, Kowall NW.J Neuropathol Exp Neurol. 1987 Jan;46(1):1-11. doi: 10.1097/00005072-198701000-00001.PMID: 3794758
Translocation of RNA granules in living neurons.
Knowles RB, Sabry JH, Martone ME, Deerinck TJ, Ellisman MH, Bassell GJ, Kosik KS.J Neurosci. 1996 Dec 15;16(24):7812-20. doi: 10.1523/JNEUROSCI.16-24-07812.1996.PMID: 8987809
Conaco C, Neveu P, Zhou H, Arcila ML, Degnan SM, Degnan BM, Kosik KS.BMC Genomics. 2012 May 30;13:209. doi: 10.1186/1471-2164-13-209.PMID: 22646746
Development of an assay to screen for inhibitors of tau phosphorylation by cdk5.
Ahn JS, Musacchio A, Mapelli M, Ni J, Scinto L, Stein R, Kosik KS, Yeh LA.J Biomol Screen. 2004 Mar;9(2):122-31. doi: 10.1177/1087057103260594.PMID: 15006135
Presenilin affects arm/beta-catenin localization and function in Drosophila.
Noll E, Medina M, Hartley D, Zhou J, Perrimon N, Kosik KS.Dev Biol. 2000 Nov 15;227(2):450-64. doi: 10.1006/dbio.2000.9925.PMID: 11071766
Giraldo M, Lopera F, Siniard AL, Corneveaux JJ, Schrauwen I, Carvajal J, Muñoz C, Ramirez-Restrepo M, Gaiteri C, Myers AJ, Caselli RJ, Kosik KS, Reiman EM, Huentelman MJ.Neurobiol Aging. 2013 Aug;34(8):2077.e11-8. doi: 10.1016/j.neurobiolaging.2013.02.016. Epub 2013 Apr 9.PMID: 23582655
Sasaki K, Shimura H, Itaya M, Tanaka R, Mori H, Mizuno Y, Kosik KS, Tanaka S, Hattori N.FEBS Lett. 2009 Jul 7;583(13):2194-200. doi: 10.1016/j.febslet.2009.06.015. Epub 2009 Jun 13.PMID: 19527721
Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL.
Donahue CP, Kosik KS.Genomics. 2004 Jan;83(1):59-65. doi: 10.1016/s0888-7543(03)00206-4.PMID: 14667809
Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP.
Morin PJ, Medina M, Semenov M, Brown AM, Kosik KS.Neurobiol Dis. 2004 Jun;16(1):59-67. doi: 10.1016/j.nbd.2004.01.004.PMID: 15207262
Banerjee S, Neveu P, Kosik KS.Neuron. 2009 Dec 24;64(6):871-84. doi: 10.1016/j.neuron.2009.11.023.PMID: 20064393
Alz-50 recognizes a phosphorylated epitope of tau protein.
Uéda K, Masliah E, Saitoh T, Bakalis SL, Scoble H, Kosik KS.J Neurosci. 1990 Oct;10(10):3295-304. doi: 10.1523/JNEUROSCI.10-10-03295.1990.PMID: 1698946
Developmentally regulated expression of specific tau sequences.
Kosik KS, Orecchio LD, Bakalis S, Neve RL.Neuron. 1989 Apr;2(4):1389-97. doi: 10.1016/0896-6273(89)90077-9.PMID: 2560640
Delayed retraction of filopodia in gelsolin null mice.
Lu M, Witke W, Kwiatkowski DJ, Kosik KS.J Cell Biol. 1997 Sep 22;138(6):1279-87. doi: 10.1083/jcb.138.6.1279.PMID: 9298983
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.
Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G.Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):360-5. doi: 10.1073/pnas.2333854100. Epub 2003 Dec 22.PMID: 14691248
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.
Shimura H, Schwartz D, Gygi SP, Kosik KS.J Biol Chem. 2004 Feb 6;279(6):4869-76. doi: 10.1074/jbc.M305838200. Epub 2003 Nov 10.PMID: 14612456
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.
Papagiannakopoulos T, Shapiro A, Kosik KS.Cancer Res. 2008 Oct 1;68(19):8164-72. doi: 10.1158/0008-5472.CAN-08-1305.PMID: 18829576
Neuritic pathology and dementia in Alzheimer's disease.
McKee AC, Kosik KS, Kowall NW.Ann Neurol. 1991 Aug;30(2):156-65. doi: 10.1002/ana.410300206.PMID: 1910274
Rook MS, Lu M, Kosik KS.J Neurosci. 2000 Sep 1;20(17):6385-93. doi: 10.1523/JNEUROSCI.20-17-06385.2000.PMID: 10964944
Highly conserved O-fucose sites have distinct effects on Notch1 function.
Rampal R, Arboleda-Velasquez JF, Nita-Lazar A, Kosik KS, Haltiwanger RS.J Biol Chem. 2005 Sep 16;280(37):32133-40. doi: 10.1074/jbc.M506104200. Epub 2005 Jul 1.PMID: 15994302
Kinesin-mediated organelle translocation revealed by specific cellular manipulations.
Feiguin F, Ferreira A, Kosik KS, Caceres A.J Cell Biol. 1994 Nov;127(4):1021-39. doi: 10.1083/jcb.127.4.1021.PMID: 7962067
Growth hormone is produced within the hippocampus where it responds to age, sex, and stress.
Donahue CP, Kosik KS, Shors TJ.Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6031-6. doi: 10.1073/pnas.0507776103. Epub 2006 Mar 30.PMID: 16574776
Ruiz-Opazo N, Kosik KS, Lopez LV, Bagamasbad P, Ponce LR, Herrera VL.Mol Med. 2004 Jan-Jun;10(1-6):36-44. doi: 10.2119/2003-00044.herrera.PMID: 15502881
Monshausen M, Gehring NH, Kosik KS.Neuromolecular Med. 2004;6(2-3):127-44. doi: 10.1385/NMM:6:2-3:127.PMID: 15970630
Association of poly(A) mRNA with microtubules in cultured neurons.
Bassell GJ, Singer RH, Kosik KS.Neuron. 1994 Mar;12(3):571-82. doi: 10.1016/0896-6273(94)90213-5.PMID: 8155320
Structure and novel exons of the human tau gene.
Andreadis A, Brown WM, Kosik KS.Biochemistry. 1992 Nov 3;31(43):10626-33. doi: 10.1021/bi00158a027.PMID: 1420178
Detection of a microRNA signal in an in vivo expression set of mRNAs.
Liu T, Papagiannakopoulos T, Puskar K, Qi S, Santiago F, Clay W, Lao K, Lee Y, Nelson SF, Kornblum HI, Doyle F, Petzold L, Shraiman B, Kosik KS.PLoS One. 2007 Aug 29;2(8):e804. doi: 10.1371/journal.pone.0000804.PMID: 17726534
Alvarez AR, Sandoval PC, Leal NR, Castro PU, Kosik KS.Neurobiol Dis. 2004 Nov;17(2):326-36. doi: 10.1016/j.nbd.2004.06.007.PMID: 15474370
Fleisher AS, Chen K, Quiroz YT, Jakimovich LJ, Gomez MG, Langois CM, Langbaum JB, Ayutyanont N, Roontiva A, Thiyyagura P, Lee W, Mo H, Lopez L, Moreno S, Acosta-Baena N, Giraldo M, Garcia G, Reiman RA, Huentelman MJ, Kosik KS, Tariot PN, Lopera F, Reiman EM.Lancet Neurol. 2012 Dec;11(12):1057-65. doi: 10.1016/S1474-4422(12)70227-2. Epub 2012 Nov 6.PMID: 23137949
Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing.
Donahue CP, Muratore C, Wu JY, Kosik KS, Wolfe MS.J Biol Chem. 2006 Aug 18;281(33):23302-6. doi: 10.1074/jbc.C600143200. Epub 2006 Jun 16.PMID: 16782711
Kumar P, Ambasta RK, Veereshwarayya V, Rosen KM, Kosik KS, Band H, Mestril R, Patterson C, Querfurth HW.Hum Mol Genet. 2007 Apr 1;16(7):848-64. doi: 10.1093/hmg/ddm030. Epub 2007 Feb 22.PMID: 17317785
delta-catenin, an adhesive junction-associated protein which promotes cell scattering.
Lu Q, Paredes M, Medina M, Zhou J, Cavallo R, Peifer M, Orecchio L, Kosik KS.J Cell Biol. 1999 Feb 8;144(3):519-32. doi: 10.1083/jcb.144.3.519.PMID: 9971746
Morphometric image analysis of neuropil threads in Alzheimer's disease.
Markesbery WR, Wang HZ, Kowall NW, Kosik KS, McKee AC.Neurobiol Aging. 1993 Jul-Aug;14(4):303-7. doi: 10.1016/0197-4580(93)90115-r.PMID: 8367011
Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.
Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS.Chem Biol. 2005 Jul;12(7):811-23. doi: 10.1016/j.chembiol.2005.05.011.PMID: 16039528
Shimura H, Miura-Shimura Y, Kosik KS.J Biol Chem. 2004 Apr 23;279(17):17957-62. doi: 10.1074/jbc.M400351200. Epub 2004 Feb 12.PMID: 14963027
C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke.
Arboleda-Velasquez JF, Lopera F, Lopez E, Frosch MP, Sepulveda-Falla D, Gutierrez JE, Vargas S, Medina M, Martinez De Arrieta C, Lebo RV, Slaugenhaupt SA, Betensky RA, Villegas A, Arcos-Burgos M, Rivera D, Restrepo JC, Kosik KS.Neurology. 2002 Jul 23;59(2):277-9. doi: 10.1212/wnl.59.2.277.PMID: 12136071
Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho.
Martinez MC, Ochiishi T, Majewski M, Kosik KS.J Cell Biol. 2003 Jul 7;162(1):99-111. doi: 10.1083/jcb.200211025. Epub 2003 Jun 30.PMID: 12835311
A detergent-insoluble membrane compartment contains A beta in vivo.
Lee SJ, Liyanage U, Bickel PE, Xia W, Lansbury PT Jr, Kosik KS.Nat Med. 1998 Jun;4(6):730-4. doi: 10.1038/nm0698-730.PMID: 9623986
Coma and axonal degeneration in vitamin B12 deficiency.
Kosik KS, Mullins TF, Bradley WG, Tempelis LD, Cretella AJ.Arch Neurol. 1980 Sep;37(9):590-2. doi: 10.1001/archneur.1980.00500580086019.PMID: 7417063
Reiman EM, Quiroz YT, Fleisher AS, Chen K, Velez-Pardo C, Jimenez-Del-Rio M, Fagan AM, Shah AR, Alvarez S, Arbelaez A, Giraldo M, Acosta-Baena N, Sperling RA, Dickerson B, Stern CE, Tirado V, Munoz C, Reiman RA, Huentelman MJ, Alexander GE, Langbaum JB, Kosik KS, Tariot PN, Lopera F.Lancet Neurol. 2012 Dec;11(12):1048-56. doi: 10.1016/S1474-4422(12)70228-4. Epub 2012 Nov 6.PMID: 23137948
Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X.Curr Biol. 2004 Sep 21;14(18):1657-63. doi: 10.1016/j.cub.2004.08.065.PMID: 15380068
Lu Q, Mukhopadhyay NK, Griffin JD, Paredes M, Medina M, Kosik KS.J Neurosci Res. 2002 Mar 1;67(5):618-24. doi: 10.1002/jnr.10151.PMID: 11891774
Ontogenesis of microtubule-associated protein 2 (MAP2) in embryonic mouse cortex.
Crandall JE, Jacobson M, Kosik KS.Brain Res. 1986 Jul;393(1):127-33. doi: 10.1016/0165-3806(86)90072-6.PMID: 3524754
Thrombotic stroke associated with elevated plasma factor VIII.
Kosik KS, Furie B.Ann Neurol. 1980 Oct;8(4):435-7. doi: 10.1002/ana.410080416.PMID: 6776880
Measuring Alzheimer's disease progression with transition probabilities: estimates from CERAD.
Neumann PJ, Araki SS, Arcelus A, Longo A, Papadopoulos G, Kosik KS, Kuntz KM, Bhattacharjya A.Neurology. 2001 Sep 25;57(6):957-64. doi: 10.1212/wnl.57.6.957.PMID: 11571317
Pathological changes in olfactory neurons in patients with Alzheimer's disease.
Talamo BR, Rudel R, Kosik KS, Lee VM, Neff S, Adelman L, Kauer JS.Nature. 1989 Feb 23;337(6209):736-9. doi: 10.1038/337736a0.PMID: 2465496
Lu Q, Paredes M, Zhang J, Kosik KS.Mol Cell Biol. 1998 Jun;18(6):3257-65. doi: 10.1128/mcb.18.6.3257.PMID: 9584166
Zhu D, Kosik KS, Meigs TE, Yanamadala V, Denker BM.J Biol Chem. 2004 Dec 31;279(53):54983-6. doi: 10.1074/jbc.C400508200. Epub 2004 Nov 3.PMID: 15525651
A microRNA array reveals extensive regulation of microRNAs during brain development.
Krichevsky AM, King KS, Donahue CP, Khrapko K, Kosik KS.RNA. 2003 Oct;9(10):1274-81. doi: 10.1261/rna.5980303.PMID: 13130141
Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred.
Pastor P, Roe CM, Villegas A, Bedoya G, Chakraverty S, García G, Tirado V, Norton J, Ríos S, Martínez M, Kosik KS, Lopera F, Goate AM.Ann Neurol. 2003 Aug;54(2):163-9. doi: 10.1002/ana.10636.PMID: 12891668
Andreadis A, Broderick JA, Kosik KS.Nucleic Acids Res. 1995 Sep 11;23(17):3585-93. doi: 10.1093/nar/23.17.3585.PMID: 7567473
Cellular signaling pathways and cytoskeletal organization.
Kosik KS, Qiu WQ, Greenberg S.Ann N Y Acad Sci. 1996 Jan 17;777:114-20. doi: 10.1111/j.1749-6632.1996.tb34409.x.PMID: 8624073 Review.
Flanagan LA, Cunningham CC, Chen J, Prestwich GD, Kosik KS, Janmey PA.Biophys J. 1997 Sep;73(3):1440-7. doi: 10.1016/S0006-3495(97)78176-1.PMID: 9284311
Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
Zhou J, Liyanage U, Medina M, Ho C, Simmons AD, Lovett M, Kosik KS.Neuroreport. 1997 May 27;8(8):2085-90. doi: 10.1097/00001756-199705260-00054.PMID: 9223106
Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
Zhou J, Liyanage U, Medina M, Ho C, Simmons AD, Lovett M, Kosik KS.Neuroreport. 1997 Apr 14;8(6):1489-94. doi: 10.1097/00001756-199704140-00033.PMID: 9172160
Epitopes that span the tau molecule are d with paired helical filaments.
Kosik KS, Orecchio LD, Binder L, Trojanowski JQ, Lee VM, Lee G.Neuron. 1988 Nov;1(9):817-25. doi: 10.1016/0896-6273(88)90129-8.PMID: 2483104
Chin LS, Li L, Ferreira A, Kosik KS, Greengard P.Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9230-4. doi: 10.1073/pnas.92.20.9230.PMID: 7568107
Medina M, Marinescu RC, Overhauser J, Kosik KS.Genomics. 2000 Jan 15;63(2):157-64. doi: 10.1006/geno.1999.6090.PMID: 10673328
Ferreira A, Lu Q, Orecchio L, Kosik KS.Mol Cell Neurosci. 1997;9(3):220-34. doi: 10.1006/mcne.1997.0615.PMID: 9245504
Cheley S, Kosik KS, Paskevich P, Bakalis S, Bayley H.J Cell Sci. 1992 Aug;102 ( Pt 4):739-52.PMID: 1331130
Competition for microtubule-binding with dual expression of tau missense and splice isoforms.
Lu M, Kosik KS.Mol Biol Cell. 2001 Jan;12(1):171-84. doi: 10.1091/mbc.12.1.171.PMID: 11160831
Distinct roles of synapsin I and synapsin II during neuronal development.
Ferreira A, Chin LS, Li L, Lanier LM, Kosik KS, Greengard P.Mol Med. 1998 Jan;4(1):22-8.PMID: 9513186
Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders.
Joachim CL, Morris JH, Kosik KS, Selkoe DJ.Ann Neurol. 1987 Oct;22(4):514-20. doi: 10.1002/ana.410220411.PMID: 2963585
Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons.
Ferreira A, Kosik KS, Greengard P, Han HQ.Science. 1994 May 13;264(5161):977-9. doi: 10.1126/science.8178158.PMID: 8178158
Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation.
Caceres A, Mautino J, Kosik KS.Neuron. 1992 Oct;9(4):607-18. doi: 10.1016/0896-6273(92)90025-9.PMID: 1389180
Shankar SK, Yanagihara R, Garruto RM, Grundke-Iqbal I, Kosik KS, Gajdusek DC.Ann Neurol. 1989 Feb;25(2):146-51. doi: 10.1002/ana.410250207.PMID: 2493213
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS.Am J Pathol. 2002 May;160(5):1655-67. doi: 10.1016/S0002-9440(10)61113-3.PMID: 12000718
Amaratunga A, Morin PJ, Kosik KS, Fine RE.J Biol Chem. 1993 Aug 15;268(23):17427-30.PMID: 7688725
Kosik KS, Crandall JE, Mufson EJ, Neve RL.Ann Neurol. 1989 Sep;26(3):352-61. doi: 10.1002/ana.410260308.PMID: 2508535
Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons.
Caceres A, Kosik KS.Nature. 1990 Feb 1;343(6257):461-3. doi: 10.1038/343461a0.PMID: 2105469
Laura RP, Witt AS, Held HA, Gerstner R, Deshayes K, Koehler MF, Kosik KS, Sidhu SS, Lasky LA.J Biol Chem. 2002 Apr 12;277(15):12906-14. doi: 10.1074/jbc.M200818200. Epub 2002 Jan 30.PMID: 11821434
The pool of map kinase associated with microtubules is small but constitutively active.
Morishima-Kawashima M, Kosik KS.Mol Biol Cell. 1996 Jun;7(6):893-905. doi: 10.1091/mbc.7.6.893.PMID: 8816996
Tau epitopes are incorporated into a range of lesions in Alzheimer's disease.
Joachim CL, Morris JH, Selkoe DJ, Kosik KS.J Neuropathol Exp Neurol. 1987 Nov;46(6):611-22. doi: 10.1097/00005072-198711000-00001.PMID: 2443617
The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain.
Nukina N, Kosik KS, Selkoe DJ.Neurosci Lett. 1988 May 3;87(3):240-6. doi: 10.1016/0304-3940(88)90455-7.PMID: 3132653
Ferreira A, Han HQ, Greengard P, Kosik KS.Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9225-9. doi: 10.1073/pnas.92.20.9225.PMID: 7568106
Overexpression of tau in a nonneuronal cell induces long cellular processes.
Knops J, Kosik KS, Lee G, Pardee JD, Cohen-Gould L, McConlogue L.J Cell Biol. 1991 Aug;114(4):725-33. doi: 10.1083/jcb.114.4.725.PMID: 1678391
Kowall NW, Kosik KS.Ann Neurol. 1987 Nov;22(5):639-43. doi: 10.1002/ana.410220514.PMID: 3122646
Hall GF, Kosik KS.Neuron. 1993 Apr;10(4):613-25. doi: 10.1016/0896-6273(93)90164-m.PMID: 8476612
Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides.
Ferreira A, Niclas J, Vale RD, Banker G, Kosik KS.J Cell Biol. 1992 May;117(3):595-606. doi: 10.1083/jcb.117.3.595.PMID: 1533397
Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS.Neurosci Lett. 1995 Sep 22;198(1):52-6. doi: 10.1016/0304-3940(95)11944-r.PMID: 8570096
Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.Science. 2001 Jul 13;293(5528):263-9. doi: 10.1126/science.1060627. Epub 2001 Jun 28.PMID: 11431533
Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, Selkoe DJ, Arango JC.Nat Med. 1996 Oct;2(10):1146-50. doi: 10.1038/nm1096-1146.PMID: 8837617
Caceres A, Potrebic S, Kosik KS.J Neurosci. 1991 Jun;11(6):1515-23. doi: 10.1523/JNEUROSCI.11-06-01515.1991.PMID: 1904479
Ardila A, Lopera F, Rosselli M, Moreno S, Madrigal L, Arango-Lasprilla JC, Arcos M, Murcia C, Arango-Viana JC, Ossa J, Goate A, Kosik KS.Arch Clin Neuropsychol. 2000 Aug;15(6):515-28.PMID: 14590205
E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles.
Lendon CL, Martinez A, Behrens IM, Kosik KS, Madrigal L, Norton J, Neuman R, Myers A, Busfield F, Wragg M, Arcos M, Arango Viana JC, Ossa J, Ruiz A, Goate AM, Lopera F.Hum Mutat. 1997;10(3):186-95. doi: 10.1002/(SICI)1098-1004(1997)10:3<186::AID-HUMU2>3.0.CO;2-H.PMID: 9298817
Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA.Brain Res. 1986 Dec;387(3):271-80. doi: 10.1016/0169-328x(86)90033-1.PMID: 3103857
Hall GF, Lee VM, Kosik KS.Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):5016-20. doi: 10.1073/pnas.88.11.5016.PMID: 2052584
Sorting of beta-actin mRNA and protein to neurites and growth cones in culture.
Bassell GJ, Zhang H, Byrd AL, Femino AM, Singer RH, Taneja KL, Lifshitz LM, Herman IM, Kosik KS.J Neurosci. 1998 Jan 1;18(1):251-65. doi: 10.1523/JNEUROSCI.18-01-00251.1998.PMID: 9412505
Tau gene expression in rat sensory neurons during development and regeneration.
Oblinger MM, Argasinski A, Wong J, Kosik KS.J Neurosci. 1991 Aug;11(8):2453-9. doi: 10.1523/JNEUROSCI.11-08-02453.1991.PMID: 1714493
Juvenile and mature MAP2 isoforms induce distinct patterns of process outgrowth.
Leclerc N, Baas PW, Garner CC, Kosik KS.Mol Biol Cell. 1996 Mar;7(3):443-55. doi: 10.1091/mbc.7.3.443.PMID: 8868472
Ho C, Zhou J, Medina M, Goto T, Jacobson M, Bhide PG, Kosik KS.J Comp Neurol. 2000 May 1;420(2):261-76.PMID: 10753311
Organization of actin and microtubules during process formation in tau-expressing Sf9 cells.
Knowles R, LeClerc N, Kosik KS.Cell Motil Cytoskeleton. 1994;28(3):256-64. doi: 10.1002/cm.970280308.PMID: 7954853
Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS.Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7104-8. doi: 10.1073/pnas.91.15.7104.PMID: 8041753
Kosik KS, Joachim CL, Selkoe DJ.Proc Natl Acad Sci U S A. 1986 Jun;83(11):4044-8. doi: 10.1073/pnas.83.11.4044.PMID: 2424016
Rosselli MC, Ardila AC, Moreno SC, Standish VC, Arango-Lasprilla JC, Tirado VM, Ossa JM, Goate AM, Kosik KS, Lopera F.J Clin Exp Neuropsychol. 2000 Aug;22(4):483-95. doi: 10.1076/1380-3395(200008)22:4;1-0;FT483.PMID: 10923058
Presenilin-1-associated abnormalities in regional cerebral perfusion.
Johnson KA, Lopera F, Jones K, Becker A, Sperling R, Hilson J, Londono J, Siegert I, Arcos M, Moreno S, Madrigal L, Ossa J, Pineda N, Ardila A, Roselli M, Albert MS, Kosik KS, Rios A.Neurology. 2001 Jun 12;56(11):1545-51. doi: 10.1212/wnl.56.11.1545.PMID: 11402113
Cunningham CC, Leclerc N, Flanagan LA, Lu M, Janmey PA, Kosik KS.J Cell Biol. 1997 Feb 24;136(4):845-57. doi: 10.1083/jcb.136.4.845.PMID: 9049250
Nukina N, Kosik KS, Selkoe DJ.Proc Natl Acad Sci U S A. 1987 May;84(10):3415-9. doi: 10.1073/pnas.84.10.3415.PMID: 3106969
Fischer I, Shea TB, Sapirstein VS, Kosik KS.Brain Res. 1986 Feb;390(1):99-109. doi: 10.1016/0165-3806(86)90156-2.PMID: 3512042
Amaratunga A, Leeman SE, Kosik KS, Fine RE.J Neurochem. 1995 May;64(5):2374-6. doi: 10.1046/j.1471-4159.1995.64052374.x.PMID: 7536813
Patterns of neuronal Rhes as a novel hallmark of tauopathies.
Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT.Acta Neuropathol. 2021 Mar 7. doi: 10.1007/s00401-021-02279-2. Online ahead of print.PMID: 33677647
Gómez-Isla T, Growdon WB, McNamara MJ, Nochlin D, Bird TD, Arango JC, Lopera F, Kosik KS, Lantos PL, Cairns NJ, Hyman BT.Brain. 1999 Sep;122 ( Pt 9):1709-19. doi: 10.1093/brain/122.9.1709.PMID: 10468510
Cholinergic function in lumbar aluminum myelopathy.
Kosik KS, Bradley WG, Good PF, Rasool CG, Selkoe DJ.J Neuropathol Exp Neurol. 1983 Jul;42(4):365-75. doi: 10.1097/00005072-198307000-00001.PMID: 6190994
Mercken M, Fischer I, Kosik KS, Nixon RA.J Neurosci. 1995 Dec;15(12):8259-67. doi: 10.1523/JNEUROSCI.15-12-08259.1995.PMID: 8613759
Kosik KS, Finch EA.J Neurosci. 1987 Oct;7(10):3142-53. doi: 10.1523/JNEUROSCI.07-10-03142.1987.PMID: 2444675
Language after bilateral cerebral infarctions.
Kosik KS.Neurology. 1980 Feb;30(2):219-20. doi: 10.1212/wnl.30.2.219.PMID: 7188806 No abstract available.
miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy.
Hinman JD, Ngo KJ, Kim D, Chen C, Abraham CR, Ghanbari M, Ikram MA, Kushner SA, Kawaguchi R, Coppola G, Goth K, Bellusci S, Hernandez I, Kosik KS, Fogel BL.Hum Mol Genet. 2021 Mar 25;30(1):103-118. doi: 10.1093/hmg/ddaa252.PMID: 33555315
Lopera F, Ardilla A, Martínez A, Madrigal L, Arango-Viana JC, Lemere CA, Arango-Lasprilla JC, Hincapíe L, Arcos-Burgos M, Ossa JE, Behrens IM, Norton J, Lendon C, Goate AM, Ruiz-Linares A, Rosselli M, Kosik KS.JAMA. 1997 Mar 12;277(10):793-9.PMID: 9052708
Neurolab: learning how the nervous system adapts to microgravity.
Kosik KS.Neurosci News. 1998;1(5):36-8.PMID: 12053888 No abstract available.
Neurotrophin-3 signals redistribute RNA in neurons.
Knowles RB, Kosik KS.Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14804-8. doi: 10.1073/pnas.94.26.14804.PMID: 9405694
Alzheimer plaques and tangles: advances on both fronts.
Kosik KS.Trends Neurosci. 1991 Jun;14(6):218-9. doi: 10.1016/0166-2236(91)90116-c.PMID: 1716011 Review. No abstract available.
Rauch JN, Valois E, Ponce-Rojas JC, Aralis Z, Lach RS, Zappa F, Audouard M, Solley SC, Vaidya C, Costello M, Smith H, Javanbakht A, Malear B, Polito L, Comer S, Arn K, Kosik KS, Acosta-Alvear D, Wilson MZ, Fitzgibbons L, Arias C.JAMA Netw Open. 2021 Feb 1;4(2):e2037129. doi: 10.1001/jamanetworkopen.2020.37129.PMID: 33570576
The long reach of evolution and development. Effects on the Alzheimer brain.
Kosik KS.Ann N Y Acad Sci. 2000;924:76-80. doi: 10.1111/j.1749-6632.2000.tb05563.x.PMID: 11193805 Review.
Paired helical filaments in human neurons: relationship to neurofilaments.
Selkoe DJ, Abraham C, Rasool CG, McCluskey A, Kosik KS, Duffy LK.Ann N Y Acad Sci. 1985;455:583-96. doi: 10.1111/j.1749-6632.1985.tb50438.x.PMID: 3936387 Review. No abstract available.
Heterogeneity of microtubule-associated protein (MAP2) in vertebrate brains.
Fischer I, Kosik KS, Sapirstein VS.Brain Res. 1987 Dec 8;436(1):39-48. doi: 10.1016/0006-8993(87)91554-x.PMID: 3690352
Kosik KS.Bioessays. 2001 Feb;23(2):203-5. doi: 10.1002/1521-1878(200102)23:2<203::AID-BIES1028>3.0.CO;2-J.PMID: 11169594 No abstract available.
Hall GF, Yao J, Selzer ME, Kosik KS.J Neurocytol. 1997 Nov;26(11):733-53. doi: 10.1023/a:1018562331003.PMID: 9426171
Molecular relation of amyloid filaments and paired helical filaments in Alzheimer's disease.
Selkoe DJ, Podlisny MB, Gronbeck A, Mammen A, Kosik KS.Adv Neurol. 1990;51:171-9.PMID: 2104686 Review. No abstract available.
Kosik KS.Ann N Y Acad Sci. 1989;568:125-30. doi: 10.1111/j.1749-6632.1989.tb12499.x.PMID: 2560894 No abstract available.
Genetic testing must recognize impact of bad news on recipient.
Kosik KS, Lopera F.Nature. 2008 Jul 10;454(7201):158-9. doi: 10.1038/454158c.PMID: 18615057 No abstract available.
Expression and phosphorylation of a three-repeat isoform of tau in transfected non-neuronal cells.
Gallo JM, Hanger DP, Twist EC, Kosik KS, Anderton BH.Biochem J. 1992 Sep 1;286 ( Pt 2)(Pt 2):399-404. doi: 10.1042/bj2860399.PMID: 1530572
A notable cleavage: winding up with beta-amyloid.
Kosik KS.Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2574-6. doi: 10.1073/pnas.96.6.2574.PMID: 10077548 No abstract available.
Ferreira A, Kincaid R, Kosik KS.Mol Biol Cell. 1993 Dec;4(12):1225-38. doi: 10.1091/mbc.4.12.1225.PMID: 8167406
Kosik KS, McCluskey AH, Walsh FX, Selkoe DJ.Neurochem Pathol. 1985 Summer;3(2):99-108. doi: 10.1007/BF02834283.PMID: 2413406
Huntington's disease: changes in striatal proteins reflect astrocytic gliosis.
Selkoe DJ, Salazar FJ, Abraham C, Kosik KS.Brain Res. 1982 Aug 5;245(1):117-25. doi: 10.1016/0006-8993(82)90344-4.PMID: 6214299
Kosik KS.Nat Med. 1999 Feb;5(2):149-50. doi: 10.1038/5510.PMID: 9930858 No abstract available.
Characterization of postmortem human brain proteins by two-dimensional gel electrophoresis.
Kosik KS, Gilbert JM, Selkoe DJ, Strocchi P.J Neurochem. 1982 Dec;39(6):1529-38. doi: 10.1111/j.1471-4159.1982.tb07985.x.PMID: 7142987
Teaching resources. A model for local regulation of translation near active synapses.
Kosik KS, Krichevsky AM.Sci STKE. 2005 Sep 6;2005(300):tr25. doi: 10.1126/stke.3002005tr25.PMID: 16145019
Microtubular reorganization and dendritic growth response in Alzheimer's disease.
McKee AC, Kowall NW, Kosik KS.Ann Neurol. 1989 Nov;26(5):652-9. doi: 10.1002/ana.410260511.PMID: 2817839
Architecture of apical dendrites in the murine neocortex: dual apical dendritic systems.
Escobar MI, Pimienta H, Caviness VS Jr, Jacobson M, Crandall JE, Kosik KS.Neuroscience. 1986 Apr;17(4):975-89. doi: 10.1016/0306-4522(86)90074-6.PMID: 3714046
Tau confers drug stability but not cold stability to microtubules in living cells.
Baas PW, Pienkowski TP, Cimbalnik KA, Toyama K, Bakalis S, Ahmad FJ, Kosik KS.J Cell Sci. 1994 Jan;107 ( Pt 1):135-43.PMID: 8175903
Kosik KS, Duffy LK, Dowling MM, Abraham C, McCluskey A, Selkoe DJ.Proc Natl Acad Sci U S A. 1984 Dec;81(24):7941-5. doi: 10.1073/pnas.81.24.7941.PMID: 6083566
McKee AC, Kosik KS, Kennedy MB, Kowall NW.J Neuropathol Exp Neurol. 1990 Jan;49(1):49-63. doi: 10.1097/00005072-199001000-00006.PMID: 2153760
Secreted beta-APP stimulates MAP kinase and phosphorylation of tau in neurons.
Greenberg SM, Kosik KS.Neurobiol Aging. 1995 May-Jun;16(3):403-7; discussion 407-8. doi: 10.1016/0197-4580(94)00172-w.PMID: 7566349
Presenilin interactions and Alzheimer's disease.
Kosik KS.Science. 1998 Jan 23;279(5350):463-5. doi: 10.1126/science.279.5350.459h.PMID: 9454341 No abstract available.
Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human.
Kosik KS, Orecchio LD, Bruns GA, Benowitz LI, MacDonald GP, Cox DR, Neve RL.Neuron. 1988 Apr;1(2):127-32. doi: 10.1016/0896-6273(88)90196-1.PMID: 3272162
Postsynaptic element contributes to the delay in synaptogenesis in synapsin I-deficient neurons.
Ferreira A, Li L, Chin LS, Greengard P, Kosik KS.Mol Cell Neurosci. 1996;8(4):286-99. doi: 10.1006/mcne.1996.0064.PMID: 9026316
Alzheimer's disease: which way is forward?
Kosik KS.Neurobiol Aging. 1994;15 Suppl 2:S91-2. doi: 10.1016/0197-4580(94)90180-5.PMID: 7700472 No abstract available.
Partial sequence of MAP2 in the region of a d epitope with Alzheimer neurofibrillary tangles.
Kosik KS, Orecchio LD, Bakalis S, Duffy L, Neve RL.J Neurochem. 1988 Aug;51(2):587-98. doi: 10.1111/j.1471-4159.1988.tb01079.x.PMID: 2455776
LeClerc N, Kosik KS, Cowan N, Pienkowski TP, Baas PW.Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6223-7. doi: 10.1073/pnas.90.13.6223.PMID: 8327502
Neuroscience gears up for duel on the issue of brain versus deity.
Kosik KS.Nature. 2006 Jan 12;439(7073):138. doi: 10.1038/439138a.PMID: 16407931 No abstract available.
The primary structure and analysis of the squid kinesin heavy chain.
Kosik KS, Orecchio LD, Schnapp B, Inouye H, Neve RL.J Biol Chem. 1990 Feb 25;265(6):3278-83.PMID: 2137456
Possible modifications of vimentin following acquisition of triton insolubility.
Kosik KS, Selkoe DJ, Sapirstein V.Biochem Int. 1984 Oct;9(4):483-90.PMID: 6517954
A possible fetal antigen of Mr 70,000 in neurofibrillary tangles.
Morishima-Kawashima M, Arai T, Ogawara M, Takio K, Titani K, Saitoh T, Kosik KS, Ihara Y.Brain Res. 1991 Jul 19;554(1-2):316-20. doi: 10.1016/0006-8993(91)90208-d.PMID: 1933313
A cDNA for a human microtubule associated protein 2 epitope in the Alzheimer neurofibrillary tangle.
Neve RL, Selkoe DJ, Kurnit DM, Kosik KS.Brain Res. 1986 Nov;387(2):193-6. doi: 10.1016/0169-328x(86)90011-2.PMID: 2431745
The exon trapping assay partly discriminates against alternatively spliced exons.
Andreadis A, Nisson PE, Kosik KS, Watkins PC.Nucleic Acids Res. 1993 May 11;21(9):2217-21. doi: 10.1093/nar/21.9.2217.PMID: 7684835
Microtubule-associated protein 2 (MAP 2) immunoreactivity in human fetal neocortex.
Sims KB, Crandall JE, Kosik KS, Williams RS.Brain Res. 1988 May 24;449(1-2):192-200. doi: 10.1016/0006-8993(88)91037-2.PMID: 3293702
Antisense inhibition of protein synthesis and function : rabbit retinal protein.
Amaratunga AP, Kosik KS, Rittenhouse PA, Leeman SE, Fine RE.Methods Mol Med. 1996;1:109-19. doi: 10.1385/0-89603-305-8:109.PMID: 21359719
Kosik KS, Bakalis SF, Selkoe DJ, Pierce MW, Duffy LK.J Neurosci Res. 1986;15(4):543-51. doi: 10.1002/jnr.490150411.PMID: 2873254