Nobel Laureate Abel Laureate Advisory Board Member USERN President USERN Policy Making Council USERN Manager USERN Deputy Junior Ambassador

Major: Immunology

Field: Cellular & molecular studies in immunology

Juan Carlos Aldave
Medical Doctor (Faculty)
Hospital Nacional Edgardo Rebagliati Martins
Jr. Domingo Cueto 371, Dpto. 301, Lince, LIMA14, Peru
Phone: (+51) 988689472. Email: jucapul_84@hotmail.com


EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

Universidad Nacional de Trujillo – Trujillo, Peru M.D. 2000-2006 General Medicine
Universidad Nacional Mayor de San Marcos – Lima, Peru Medical Specialist 2008-2011 Allergy and Clinical Immunology
Universidad Nacional Mayor de San Marcos – Lima, Peru MSc 2013-2014 Health Research and Teaching


A. Personal Statement:

My career is dedicated to promote clinical and research development in Primary Immunodeficiencies (PIDs) in Peru, to provide the best possible care to PID-affected Peruvian patients.

In June 2008, I began my residency in Allergy and Clinical Immunology in Edgardo Rebagliati Martins National Hospital (Lima, Peru), where my interest in PIDs started. In November 2010, I did an Observership in the Immunology Division of Children’s Hospital of Boston, where I observed a higher number of PID affected patients than in my hospital. Then, I realized that the main problem in Peru was the lack of medical awareness about PIDs. After returning to Peru, in April 2011, we organized the first PID Workgroup in my hospital (Immunology, Infectology, Hematology, Genetics, and Clinical Pediatrics physicians) to increase awareness, early diagnosis, appropriate treatment and timely report of PID affected Peruvian patients. Since then we have worked hardly to achieve these goals. In September 2011, with the support of the IUIS, we organized the First Peruvian Educational Meeting in PIDs, which was a very encouraging event. In March 2012, we organized the Peruvian Group of Primary Immunodeficiencies (PERUGID). During the last 5 years I have attended many international congresses and schools, to increase my knowledge about PID and to meet experts who could help me in the management of PID Peruvian patients, especially by providing molecular diagnosis or giving me suggestions for patient care.

Every day is a new journey to improve PID work in Peru. Although there are many limitations to our work, especially by economic and technological issues, every week or month we receive great news: more people are interested to work in PIDs, more patients are identified with suspicion of PID, more patient samples are accepted in international centres for genetic studies, more patients receive HSCT, new possibilities to establish agreements with international centres for patient care appear, etc.

One year ago we established the Jeffrey Modell Foundation Network in Peru. Our main plans are: to increase PID awareness in Peruvian physicians, to promote universal access to treatment with immunoglobulin, to set up a newborn screening program for Severe Combined Immunodeficiencies (SCID), and to increase the number of patients receiving timely Hematopoietic Stem Cell Transplantation (HSCT). Our PID team in Peru has grown from 6 members in 2011 to 17 members in 2017.


B. Positions and Honors:

DATE (mm/yy)
DATE (mm/yy)
Medical residency 06/08 05/11 Allergy and Clinical Immunology Edgardo Rebagliati Martins National Hospital (Lima, Peru) Armando Koo
Faculty (medical doctor) 06/12 present Allergy and Clinical Immunology Edgardo Rebagliati Martins National Hospital (Lima, Peru) Luis Núñez
Professor 03/12 present Immunology Universidad Peruana Cayetano Heredia (Lima-Peru) José Aguilar
Chief 01/17 present Primary Immunodeficiency Unit Edgardo Rebagliati Martins National Hospital (Lima, Peru) Luis Núñez


Memberships in professional societies:

  • 2010: European Academy of Allergy and Clinical Immunology Junior Member.
  • 2011: Coordinator of the Primary Immunodeficiencies Committee of the Latin-American Association of Immunology.
  • 2011: European Society for Immunodeficiencies (ESID) Junior Member.
  • 2011: World Allergy Organization (WAO) Junior Member.
  • 2011: American College of Allergy, Asthma & Immunology International Affiliate Member.
  • 2011: Member of the Latin American Society for Immunodeficiencies (LASID).
  • 2012: Member of the WAO Special Committee on Eosinophil and Mast Cell Disorders.
  • 2012: Member of the Clinical Immunology Committee of the International Union of Immunological Societies (IUIS).
  • 2012: Member of the Clinical Immunology Society (CIS).
  • 2012: Member of the Peruvian Group for Primary Immunodeficiencies (PERUGID)
  • 2012: Member of the expert panel of the WAO Ask the Expert feature.
  • 2013: Member of the FIT/NIT Committee of the Clinical Immunology Society (CIS)
  • 2013: Member of the physician panel of the World Allergy Organization (WAO) Book Review feature.
  • 2014: Editor-at-large of the World Allergy Organization (WAO) Webpage.
  • 2016: Director of the Jeffrey Modell Foundation Peruvian Network.
  • 2016: European Society for Immunodeficiencies (ESID) Junior Country Representative.
  • 2017: Vice-president of the Peruvian Society of Immunology.
  • 2017: Chief of the Primary Immunodeficiency Unit of the Immunology Division of Hospital Nacional Edgardo Rebagliati Martins.


C.  Publications:

  • Aldave J, Cachay E, Núñez L, Chunga A, Murillo S, Cypowyj S, Bustamante J, Puel A, Casanova JL, Koo A. A 1-Year-Old Girl with a Gain-of-Function STAT1 Mutation Treated with Hematopoietic Stem Cell Transplantation. J Clin Immunol 2013; 33: 1273–1275.
  • Cabral-Marques O, Klaver S, Schimke LF, Ascendino EH, Khan TA, Pereira PV, Falcai A, Vargas-Hernández A, Santos-Argumedo L, Bezrodnik L, Moreira I, Seminario G, Di Giovanni D, Raccio AG, Porras O, Weber CW, Ferreira JF, Tavares FS, de Carvalho E, Valente CF, Kuntze G, Galicchio M, King A, Rosário-Filho NA, Grota MB, Dos Santos Vilela MM, Di Gesu RS, Lima S, de Souza Moura L, Talesnik E, Mansour E, Roxo-Junior P, Aldave JC, Goudouris E, Pinto-Mariz F, Berrón-Ruiz L, Staines-Boone T, Calderón WO, Del Carmen Zarate-Hernández M, Grumach AS, Sorensen R, Durandy A, Torgerson TR, Carvalho BT, Espinosa-Rosales F, Ochs HD, Condino-Neto A. First Report of the Hyper-IgM Syndrome Registry of the Latin American Society for Immunodeficiencies: Novel Mutations, Unique Infections, and Outcomes. J Clin Immunol 2014; 34:146–156.
  • Crestani E, Volpi S, Candotti F, Giliani S, Notarangelo LD, Chu J, Aldave Becerra JC, Buchbinder D, Chou J, Geha RS, Kanariou M, King A, Mazza C, Moratto D, Sokolic R, Garabedian E, Porta F, Putti MC, Wakim RH, Tsitsikov E, Pai SY, Notarangelo LD. Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J Allergy Clin Immunol. 2015; 136(5): 1401-1404.
  • Tanno LK, Darlenski R, Sánchez-Garcia S, Bonini M, Vereda A, Kolkhir P, Antolin-Amerigo D, Dimov V, Gallego-Corella C, Aldave Becerra JC, Diaz A, Bellido Linares V, Villa L, Rosenwasser LJ, Sanchez-Borges M, Ansotegui I, Pawankar R, Bieber T. International survey on skin patch test procedures, attitudes and interpretation. World Allergy Organization Journal 2016; 9:8.
  • Toubiana J, Okada S, Hiller J, Oleastro M, Lagos Gomez M, Aldave Becerra JC, Ouachée-Chardin M, Fouyssac F, Girisha KM, Etzioni A, Van Montfrans J, Camcioglu Y, Kerns LA, Belohradsky B, Blanche S, Bousfiha A, Rodriguez-Gallego C, Meyts I, Kisand K, Reichenbach J, Renner ED, Rosenzweig S, Grimbacher B, van de Veerdonk FL, Traidl-Hoffmann C, Picard C, Marodi L, Morio T, Kobayashi M, Lilic D, Milner JD, Holland S, Casanova JL, Puel A. Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype: an international survey of 274 patients from 167 kindreds. Blood 2016; 127(25):3154-64.
  • Stray-Pedersen A, Sørmo Sorte H, Samarakoon P, Gambin T, Chinn IK, Coban Akdemir ZH, Erichsen HC, Forbes LR, Gu Sh, Yuan B, Jhangiani SN, Muzny DM, Rødningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO, Davis C, Canter D, Mace EM, Vece T, Allen CE, Abhyankar HA, Boone P, Beck CR, Wiszniewski WK, Fevang B, Aukrust P, Tjønnfjord GE, Gedde-Dahl T, Hjorth-Hansen H, Dybedal I, Nordøy I, Jørgensen SF, Abrahamsen  TG, Øverland T, Bechensteen AG, Skogen V, Osnes LT, Kulseth MA, Prescott TE, Rustad CF, Heimdal KR, Belmont JW, Rider N, Chinen J, Cao T, Smith E, Caldirola MS, Bezrodnik L, Lugo Reyes SO, Espinosa Rosales FJ, Guerrero D, Pedroza LA, Poli CM, Franco JL, Trujillo Vargas CM, Aldave Becerra JC, Wright N,  Issekutz TB, Issekutz AC, Abbott J, Caldwell JW, Bayer DK, Chan AY, Aiuti A, Cancrini C, Holmberg E, West Ch, Burstedt M, Karaca E, Yesil G, Artac H, Bayram Y, Musa Atik M, Eldomery MK, Ehlayel MS, Jolles S, Flatø B, Bertuch AA, Hanson IC, Zhang VW, Wong L-J, Hu J, Walkiewicz M, Yang Y, Eng Ch, Boerwinkle E, Gibbs RA, Shearer WT, Lyle R, Orange JS, Lupski JR. Primary immunodeficiency diseases – genomic approaches delineate heterogeneous Mendelian disorders. J Allergy Clin Immunol. 2017 Jan;139(1):232-245. DOI: http://dx.doi.org/10.1016/j.jaci.2016.05.042.
  • Aldave Becerra JC, Cachay Rojas E. A 3-Year-Old Girl with Recurrent Infections and Autoimmunity due to a STAT1 Gain-of-Function Mutation: The Expanding Clinical Presentation of Primary Immunodeficiencies. Front Pediatr. 2017. 5:55. doi: 10.3389/fped.2017.00055. eCollection 2017.
  • Leiding JW, Okada S, Hagin D, Abinun M, Shcherbina A, Balashov DN, Kim VHD, Ovadia A, Guthery SL, Pulsipher M, Lilic D, Devlin LA, Christie S, Depner M, Fuchs S, van Royen-Kerkhof A, Lindemans C, Petrovic A, Sullivan KE, Bunin N, Kilic SS, Arpaci F, Calle-Martin O, Martinez-Martinez L, Aldave JC, Kobayashi M, Ohkawa T, Imai K, Iguchi A, Roifman CM, Gennery AR, Slatter M, Ochs HD, Morio T, Torgerson TR; Inborn Errors Working Party of EBMT and the PIDTC. Hematopoietic stem cell transplantation in patients with Gain of Function STAT1 Mutation. J Allergy Clin Immunol. 2017 Jun 7. pii: S0091-6749(17)30916-8. doi: 10.1016/j.jaci.2017.03.049. [Epub ahead of print]
  • From January 2013 to September 2014, elaboration of the Continuous Medical Education Booklets: “Pearls in Allergy and Clinical Immunology”, for the WAO, CIS and ESID Junior Members.
  • Author of the Book Collection “Funny Immunology to Save Lives”, composed of 11 books: “The Immunocytes”, “The TH17 army against Candida”, “The TH1 army against Mycobacteria”, “The TH2 army against worms”, “The battle against Pneumococcus”, “Immunocytes against cancer”, “T regs: controlling the immune army”, “When immunocytes get sick”, “When immunocytes go crazy”, “The Immunocytes and Transplantation”, and “The Interleukins”.


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