Nobel Laureate Abel Laureate Advisory Board Member USERN President USERN Policy Making Council USERN Manager USERN Deputy Junior Ambassador

Major: Clinical Medicine


PhD, Biology, University of Oregon

MSc, Mathematical Statistics, University of Oregon


Dr. Hong-Wen Deng is an internationally renowned researcher/educator with extensive multi-/inter-disciplinary expertise in biostatistics and bioinformatics methodology research, big data, genomics, transcriptomics, epigenomics, proteomics, genetic epidemiology, complex traits and diseases (especially osteoporosis, sarcopenia and obesity), system biology, endocrinology, bone biology and recently metabolomics and metagenomics. Deng’s work is published in nearly 600 peer-reviewed publications including journals such as Nature, New England Journal of Medicine, American Journal of Human Genetics, Endocrine Review, Plos Genetics, Human Molecular Genetics, Molecular Psychiatry, Bioinformatics, and Molecular Cell Proteomics. As of April 2019, these publications have been cited more than18,600 times and his H-index is 69 and i10 index is 374. Deng’s primary research interests include all those areas that are related addressing the question: What and how genetic and environmental factors incur higher risk of, or better protection against, complex diseases, such as osteoporosis, in different sex and ethnic groups. Theoretical (e.g., methodology development in biostatistics/bioinformatics) and empirical (e.g., clinical data collection and wet/dry labs data collection/management/processing/analyses) approaches are used. We are most interested in generating, analyzing and integrating big data of various omics in vivo in humans. The purpose is to elucidate how DNA variants affect gene expression/regulation and protein expression/modification in the form of functional networks/modules/pathways and how the knowledge gained on these molecular mechanisms in humans would translate into better prediction/intervention/precision medicine and drug development. Dr. Deng has won numerous NIH grants, including P50 center grant and U19 program grant and has advised/mentored more than 100 graduate students and faculty. Many of his mentees have become tenured professors wining their own grants with their own research centers/programs and some become academic and industrial administrators such as associate deans, department chairs and vice president of genomics companies.


Please view Dr. Deng's publications at his NCBI profile page.

Faculty Info

Research Areas

  • Multi-omics (Including Metagenomics) and Trans-omics
  • Biostatistics and Bioinformatics
  • Genetics of Complex Diseases
  • Single Cell Sequencing
  • Big Data
  • Machine Learning (Including Deep Learning)
  • Data Analytics
  • Osteoporosis, Sarcopenia, Obesity, and Other Complex Diseases


  • BIOS 7990 Independent Study
  • BIOS 8000 Doctoral Student Journal Club

Honors & Awards

  • 2006: Fuller Albright Award, American Society of Bone and Mineral Research
  • 2004: IOF-SERVIER Young Investigator Award, International Osteoporosis Foundation
  • 2001: Cheng Kong Distinguished Professorship, Ministry of Education, P. R. China
  • 1999, 2000: ASBMR Young Investigator Award, 21st and 22nd  Annual Meetings of ASBMR
  • 1999: John Haddad Young Investigator Award, 1st AIMM-ASBMR John Haddad Meeting
  • 1999: Young Investigator Award, Medical School, Creighton University
  • 1998: Travel Award, ASBMR-IBMS annual meeting...



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